Results 81 to 90 of about 22,628 (189)
Bipolar Disorders, Volume 28, Issue 4, June 2026.ABSTRACT Background Bipolar disorder (BD) is among the most heritable psychiatric disorders, with a genetic architecture likely consisting of both common genetic variants with small effects and rare variants with strong effects in certain families or populations.
Albert H. C. Wong +8 more
wiley +1 more source
Deletion of Robo4 worsens neuroinflammation in a mouse model of Alzheimer's disease
Physiological Reports, Volume 14, Issue 11, June 2026.Abstract Declines in vascular integrity are potential contributors to Alzheimer's disease (AD) as these result in increased blood–brain barrier permeability and, consequently, accelerate neuroinflammation and cognitive impairment. Roundabout guidance receptor 4 (Robo4) is primarily expressed in endothelial cells and stabilizes the vasculature, thereby ...
Abigail E. Cullen +8 more
wiley +1 more source
Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
Antioxidants, 2018 Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies.
Shaarika Sarasija, Kenneth R. Norman
doaj +1 more source
Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1
RSC Advances, 2019 We constructed a model of presenilin-2 γ-secretase in the membrane and studied it by all-atom molecular dynamics simulations. The study provides the first structural-dynamic comparison of presenilin 1 and 2 relevant to Alzheimer's disease.
Budheswar Dehury +3 more
openaire +4 more sources
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
Frontiers in Physiology, 2017 Mitochondrial dysfunction plays a pivotal role in the progression of Alzheimer's disease (AD), and yet the mechanisms underlying the impairment of mitochondrial function in AD remain elusive.
Sabrina Contino +11 more
doaj +1 more source
Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Journal of Lipid Research, 2004 Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease.
Yanzhu Liu +5 more
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Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
IbrainAlzheimer's disease (AD), a neurodegenerative disease leading to dementia, lacks a single definitive diagnosis. While current medications only manage symptoms, the ideal treatment would restore cognition.
Tapas Kumar Mohapatra +4 more
doaj +1 more source
Chromosome Missegregation and Trisomy 21 Mosaicism in Alzheimer's Disease
Neurobiology of Disease, 1999 A connection between Alzheimer's disease (AD) and Down syndrome (trisomy 21) is indicated by the fact that all Down syndrome individuals develop Alzheimer's disease neuropathology by the 4th decade of life. Previous studies have examined the frequency of
Lisa N. Geller, Huntington Potter
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Mutations, associated with early-onset Alzheimer’s disease, discovered in Asian countries
Clinical Interventions in Aging, 2016 Eva Bagyinszky,1,* Young Chul Youn,2 Seong Soo A An,1 SangYun Kim3,* 1Department of BioNano Technology, Gachon University, Gyeonggi-do, 2Department of Neurology, College of Medicine, Chung-Ang University, Seoul, 3Department of Neurology, Seoul National ...
Bagyinszky E, Youn YC, An SSA, Kim S
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