Results 41 to 50 of about 22,628 (189)
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
Neurobiology of Disease, 1998 Mutations in two related genes, presenilin 1 and 2 presenilin 2 (PS1 and PS2), cosegregate with Alzheimer's disease. PS1 and PS2 are highly homologous polytopic membrane proteins that are subject to endoproteolytic cleavage in vivo. The resulting N- and C-terminal derivatives are the preponderant PS-related species that accumulate in cultured cells and
Gopal Thinakaran +6 more
openaire +3 more sources
Association of active γ-secretase complex with lipid rafts
Journal of Lipid Research, 2005 Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet clear, several studies have provided evidence for the involvement of cholesterol-rich lipid rafts in the production of amyloid
Yasuomi Urano +9 more
doaj +1 more source
Brain Pathology, EarlyView.Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari +10 more
wiley +1 more source
Presenilin‐directed inhibitors of γ‐secretase trigger caspase 3 activation in presenilin‐expressing and presenilin‐deficient cells [PDF]
Journal of Neurochemistry, 2004 AbstractThe amyloid β peptide (Aβ) is generated by subsequent cleavages by β‐ and γ‐secretases. Therefore, these two enzymes are putative therapeutic targets to prevent Aβ production, and hopefully to slow down or even stop the Alzheimer's disease (AD) neurodegenerative process.
Cristine, Alves da Costa +4 more
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Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2 [PDF]
Scientific Reports, 2018 AbstractMutations in the presenilin genes (PS1 and PS2) are a major cause of familial-Alzheimer’s disease (FAD). Presenilins regulate neurogenesis in the developing brain, with loss of PS1 inducing aberrant premature differentiation of neural progenitor cells, and additional loss of PS2 exacerbating this effect.
Jagroop Dhaliwal +8 more
openaire +2 more sources
A genetic screen of the mutations in the Korean patients with early-onset Alzheimer’s disease
Clinical Interventions in Aging, 2016 Seong Soo An,1,* Sun Ah Park,2,* Eva Bagyinszky,1 Sun Oh Bae,1 Yoon-Jeong Kim,2 Ji Young Im,2 Kyung Won Park,3 Kee Hyung Park,4 Eun-Joo Kim,5 Jee Hyang Jeong,6 Jong Hun Kim,7 Hyun Jeong Han,8 Seong Hye Choi,9 SangYun Kim10 1Department of Bionano ...
An SS +13 more
doaj
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
Neural Regeneration Research, 2022 The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer’s disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is
Mercedes A Hernandez-Sapiens +8 more
doaj +1 more source
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver
Cells, 2020 The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of ...
Gayane Hrachia Buniatian +22 more
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