Results 21 to 30 of about 42,007 (233)
Frontiers in Cell and Developmental Biology, 2023 It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these ...
Rupkatha Banerjee, Shermali Gunawardena
doaj +1 more source
Modeling Alzheimer’s Disease in Caenorhabditis elegans
Biomedicines, 2022 Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins
Javier Alvarez +4 more
doaj +1 more source
Biomolecules, 2020 The increasing detection of infections of Trypanosoma cruzi, the etiological agent of Chagas disease, in non-endemic regions beyond Latin America has risen to be a major public health issue.
Guilherme C. Lechuga +5 more
doaj +1 more source
Antioxidants, 2022 Mitochondrial dysfunction and oxidative stress are major contributors to the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD).
Kerry C. Ryan +2 more
doaj +1 more source
Village guards as “in between” in the Turkish-Kurdish conflict: Re-examining identity and position in intergroup conflict [PDF]
, 2019 The current paper utilizes new approaches in intergroup conflict studies to examine the village guard system and its role in the Turkish-Kurdish conflict in Turkey.
Acar, Yasemin Gülsüm
core +3 more sources
Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is the most common form of dementia, with no cure to stop its progression. Early detection, diagnosis, and intervention have become the hot spots in AD research.
Qiongqiong Qiu +4 more
doaj +1 more source
Loss of presenilin function is associated with a selective gain of APP function
eLife, 2016 Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to dominant-inheritance of early-onset familial Alzheimer’s disease (FAD).
Carole Deyts +5 more
doaj +1 more source
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction [PDF]
, 2010 Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients.
Ho, Angela +5 more
core +1 more source
Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]
, 2007 Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Christian Haass +15 more
core +2 more sources
Signaling Functions of Intramembrane Aspartyl-Proteases
Frontiers in Cardiovascular Medicine, 2020 Intramembrane proteolysis is more than a mechanism to “clean” the membranes from proteins no longer needed. By non-reversibly modifying transmembrane proteins, intramembrane cleaving proteases hold key roles in multiple signaling pathways and often ...
Alkmini A. Papadopoulou +2 more
doaj +1 more source