Results 21 to 30 of about 22,628 (189)
Signaling Functions of Intramembrane Aspartyl-Proteases
Frontiers in Cardiovascular Medicine, 2020 Intramembrane proteolysis is more than a mechanism to “clean” the membranes from proteins no longer needed. By non-reversibly modifying transmembrane proteins, intramembrane cleaving proteases hold key roles in multiple signaling pathways and often ...
Alkmini A. Papadopoulou +2 more
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Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts
Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is a genetic and sporadic neurodegenerative disease characterized by extracellular amyloid-β-protein (Aβ) aggregates as amyloid plaques and neuronal loss in the brain parenchyma of patients.
Kun Zou +7 more
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Spastic paraplegia preceding PSEN1‐related familial Alzheimer's disease
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021 Introduction We investigated the frequency, neuropathology, and phenotypic characteristics of spastic paraplegia (SP) that precedes dementia in presenilin 1 (PSEN1) related familial Alzheimer's disease (AD).
Viorica Chelban +23 more
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G3: Genes, Genomes, Genetics, 2020 Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson +11 more
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Genome biology, 2002 The presenilins are evolutionarily conserved transmembrane proteins that regulate cleavage of certain other proteins in their transmembrane domains. The clinical significance of this regulation is shown by the contribution of presenilin mutations to 20-50% of early-onset cases of inherited Alzheimer's disease.
Tandon, Anurag, Fraser, Paul
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Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2 γ-Secretase Complexes [PDF]
Journal of Biological Chemistry, 2009 gamma-Secretase is known to play a pivotal role in the pathogenesis of Alzheimer disease through production of amyloidogenic Abeta42 peptides. Early onset familial Alzheimer disease mutations in presenilin (PS), the catalytic core of gamma-secretase, invariably increase the Abeta42:Abeta40 ratio.
Lisa, Placanica +7 more
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Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells
Translational Neuroscience, 2016 Presenilin 1 (PS1) and PS2 are evolutionarily conserved transmembrane proteins of the aspartyl protease family. Initially, they were reported to be associated with the early onset of familial, early-onset Alzheimer’s disease.
Kumar Ashish +2 more
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Chemistry & Biology, 1999 Familial forms of Alzheimer's disease are caused by mutations in the genes encoding the presenilins, which are integral membrane proteins. Presenilins have been shown to interact with beta-amyloid precursor proteins and Notch receptors. Several recent studies have examined the role of presenilins in Notch processing.
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Biomedicines, 2021 Triple negative breast cancer (TNBC) is observed in ~15% of breast cancers and results in poor survival and increased distant metastases. Within the tumor are present a small portion of cancer stem cells that drive tumorigenesis and metastasis.
Prabhu Ramamoorthy +3 more
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Microorganisms, 2021 Nicastrin (NICT) is a transmembrane protein physically associated with the polytypical aspartyl protease presenilin that plays a vital role in the correct localization and stabilization of presenilin to the membrane-bound γ-secretase complex.
Guilherme Curty Lechuga +5 more
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