Results 11 to 20 of about 42,007 (233)
Presenilin/γ-secretase and inflammation [PDF]
Frontiers in Aging Neuroscience, 2010 Presenilins (PS) are the catalytic components of gamma-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins. Specially relevant is the gamma-secretase-dependent cleavage of the beta-amyloid precursor protein (APP) since generates the beta-amyloid (Abeta) peptides that aggregate and ...
Carlos A Saura
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Frontiers in Pharmacology, 2022 Although dysautonomia was documented in inflammatory bowel disease, with activation of the stress-related sympathetic system, the role of agonists/antagonists of the adrenergic receptors is not conclusive. Moreover, ulcerative colitis was recently linked
Salma Nasser +4 more
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Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD), a neurodegenerative disorder that can occur in middle or old age, is characterized by memory loss, a continuous decline in thinking, behavioral and social skills that affect the ability of an individual to function independently.
Gustavo Lopez-Toledo +6 more
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Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. [PDF]
PLoS ONE, 2009 Much of our current understanding about neurodegenerative diseases can be attributed to the study of inherited forms of these disorders. For example, mutations in the presenilin 1 and 2 genes have been linked to early onset familial forms of Alzheimer's ...
Kinga Michno +4 more
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Frontiers in Aging Neuroscience, 2022 The amyloid hypothesis for the pathogenesis of Alzheimer’s disease (AD) is widely accepted. Last year, the US Food and Drug Administration considered amyloid-β peptide (Aβ) as a surrogate biomarker and approved an anti-Aβ antibody, aducanumab, although ...
Shigeki Kawabata
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eLife, 2022 Cleavage of membrane proteins in the lipid bilayer by intramembrane proteases is crucial for health and disease. Although different lipid environments can potently modulate their activity, how this is linked to their structural dynamics is unclear. Here,
Lukas P Feilen +5 more
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Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
Cells, 2022 The PSEN1 ΔE9 mutation causes a familial form of Alzheimer’s disease (AD) by shifting the processing of amyloid precursor protein (APP) towards the generation of highly amyloidogenic Aβ42 peptide.
Henna Jäntti +18 more
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Frontiers in Genetics, 2023 Heparan sulfate modified proteins or proteoglycans (HSPGs) are an abundant class of cell surface and extracellular matrix molecules. They serve important co-receptor functions in the regulation of signaling as well as membrane trafficking.
Nicholas Schultheis +8 more
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Intramembrane proteolysis by presenilin and presenilin-like proteases [PDF]
Journal of Cell Science, 2003 Regulated intramembrane proteolysis is a novel mechanism involving proteases that hydrolyze their substrates in a hydrophobic environment. Presenilin (PS) 1 and PS 2 are required for intramembrane cleavage of an increasing number of type I membrane proteins, including the amyloid precursor protein of Alzheimer's disease and the Notch receptor, which ...
Weiming, Xia, Michael S, Wolfe
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The Amyloid Cascade Hypothesis in Alzheimer’s Disease: Should We Change Our Thinking?
Biomolecules, 2023 Old age increases the risk of Alzheimer’s disease (AD), the most common neurodegenerative disease, a devastating disorder of the human mind and the leading cause of dementia.
Markku Kurkinen +5 more
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