Results 11 to 20 of about 22,628 (189)
Frontiers in Cell and Developmental Biology, 2023 It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these ...
Rupkatha Banerjee, Shermali Gunawardena
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Modeling Alzheimer’s Disease in Caenorhabditis elegans
Biomedicines, 2022 Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins
Javier Alvarez +4 more
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Biomolecules, 2020 The increasing detection of infections of Trypanosoma cruzi, the etiological agent of Chagas disease, in non-endemic regions beyond Latin America has risen to be a major public health issue.
Guilherme C. Lechuga +5 more
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Antioxidants, 2022 Mitochondrial dysfunction and oxidative stress are major contributors to the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD).
Kerry C. Ryan +2 more
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The presenilins and Alzheimer's disease [PDF]
Human Molecular Genetics, 1997 The presenilin 1 and presenilin 2 genes have been identified as pathogenic loci involved in the majority of early onset, autosomal dominant Alzheimer's disease. A series of (predominantly) missense mutations have been identified in the two genes which lead to disease. The presenilins are probably eight transmembrane domain proteins with both termini in
M, Hutton, J, Hardy
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Function and Dysfunction of the Presenilins [PDF]
The American Journal of Human Genetics, 1999 Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common type of dementia, occurring in mid to late life. The neuropathological hallmarks of this disease include the presence of extracellular deposits of highly fibrillogenic Aβ42 peptides in senile plaques and intraneuronal accumulations of hyperphosphorylated τ in ...
Sisodia, Sangram S. +2 more
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Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is the most common form of dementia, with no cure to stop its progression. Early detection, diagnosis, and intervention have become the hot spots in AD research.
Qiongqiong Qiu +4 more
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Versatility of presenilin 1 [PDF]
Proceedings of the National Academy of Sciences, 2017 Mutations in PSEN1 and PSEN2 genes, encoding presenilin 1 (PS1) and presenilin 2 (PS2), respectively, cause autosomal-dominant Alzheimer’s disease (ADAD) (1, 2). The precise mechanism by which PS1 mutations lead to AD is under active investigation. Multiple theories have been suggested to explain the role of PS1 and PS2 mutations on AD pathogenesis ...
Georgia R, Frost +2 more
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Loss of presenilin function is associated with a selective gain of APP function
eLife, 2016 Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to dominant-inheritance of early-onset familial Alzheimer’s disease (FAD).
Carole Deyts +5 more
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Presenilin: RIP and beyond [PDF]
Seminars in Cell & Developmental Biology, 2009 Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to
Matthew R, Hass +3 more
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