Results 131 to 140 of about 40,397 (225)

Presenilin-1 [PDF]

, 2020
openaire   +1 more source

Functional Domains in Presenilin 1 [PDF]

Journal of Biological Chemistry, 2004
Hanna Laudon, Helena Karlström, Paul M. Mathews, Mark R. Farmery, Samuel E. Gandy, Johan Lundkvist, Urban Lendahl, Jan Näslund   +7 more
openaire   +1 more source

Alzheimer hastalarında presenilin 1 polimorfizmi

, 2020
52
openaire   +1 more source

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Kelvin A. Yamada, Lin Xu, Steven N. Johnson, Susan Farr, William Banks   +5 more
core   +1 more source

Interaction of Alzheimer's Presenilin-1 and Presenilin-2 with Bcl-XL [PDF]

Journal of Biological Chemistry, 1999
Brent J. Passer, Luca Pellegrini, Pasquale Vito, J. Kelly Ganjei, Luciano D'Adamio   +4 more
openaire   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

Pleiotropic effects of variants in dementia genes in Parkinson disease [PDF]

, 2018
Benitez, Bruno A, Budde, John, Cooper, Breanna, Cruchaga, Carlos, David, Albert A, Diez-Fairen, Monica, Dube, Umber, Fernandez, Maria V, Ibanez, Laura, Ortega-Cubero, Sara, Pastor, Pau, Perlmutter, Joel S   +11 more
core   +2 more sources

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease

Acta Neuropathologica Communications
The recently discovered interaction between presenilin 1 (PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major brain glutamate transporter (EAAT2 in the human), may link two pathological aspects of Alzheimer ...
Florian Perrin, Lauren C. Anderson, Shane P. C. Mitchell, Priyanka Sinha, Yuliia Turchyna, Masato Maesako, Mei C. Q. Houser, Can Zhang, Steven L. Wagner, Rudolph E. Tanzi, Oksana Berezovska   +10 more
doaj   +1 more source

Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease. [PDF]

Int J Mol Sci, 2023
Yang Y, Bagyinszky E, An SSA.
europepmc   +1 more source

In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2. [PDF]

Neuromolecular Med
Begum S, De Alvarez JA, Manzoni C, Arber C, Lewis PA.   +4 more
europepmc   +1 more source