Results 151 to 160 of about 40,397 (225)

Role of Presenilin-1 in Aggressive Human Melanoma. [PDF]

Int J Mol Sci, 2022
Sidor J, Gillette M, Dezi LA, Untiveros G, Strizzi L.   +4 more
europepmc   +1 more source

Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. [PDF]

Nat Commun, 2022
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y.   +10 more
europepmc   +1 more source

Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene. [PDF]

Int J Mol Sci, 2022
Bagaria J, Bagyinszky E, An SSA.
europepmc   +1 more source

Novel Association of the <i>Presenilin-1</i> (Leu282Arg) Mutation with Isolated Spastic Paraparesis: Case Presentation and Review of Current Evidence. [PDF]

J Clin Med
De la Sen-Domínguez M, Delgado-Alvarado M, Torres-Barquin M, Quirce R, Riancho J.   +4 more
europepmc   +1 more source

Case Report: Acute Psychiatric Behavioral Disturbance in a Patient with Presenilin 1 Gene Mutation Associated with Familial Alzheimer's Disease. [PDF]

Neurol Ther
Xia Y, Liu X, Cui W, Zhi Q, Sun Y.
europepmc   +1 more source

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex Formation. [PDF]

Biomolecules
Devkota S, Maesako M, Wolfe MS.
europepmc   +1 more source

Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout mice. [PDF]

Front Aging Neurosci, 2022
Peng W, Xie Y, Liao C, Bai Y, Wang H, Li C.   +5 more
europepmc   +1 more source

Rare A360T Mutation Alters GSK3β(Ser9) Binding in the Cytosolic Loop of Presenilin 1, Influencing β-Catenin Nuclear Localization and Pro-Death Gene Expression in Alzheimer's Disease Case. [PDF]

Int J Mol Sci, 2023
Wężyk M, Berdyński M, Figarski A, Skrzypczak M, Ginalski K, Zboch M, Winkel I, Żekanowski C.   +7 more
europepmc   +1 more source

Mitochondrial dysfunction and Ca²⁺ dysregulation in human iPSC-derived neurons carrying presenilin-1 mutation arise under stress via an MCU-1-independent mechanism. [PDF]

Sci Rep
Wilson C, Galeano P, Remedi MM, Novack GV, Campanelli L, Gastaldi L, Miglietta E, Rossi AH, Olivar N, Brusco LI, Castaño EM, Cáceres A, Morelli L.   +12 more
europepmc   +1 more source

TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail. [PDF]

J Biol Chem
Moon OR, Newman AC, Alanazi AS, Wehenkel SC, Gawel-Bęben K, Ivetic A, Price DA, Knäuper V, Ager A.   +8 more
europepmc   +1 more source