Results 111 to 120 of about 1,511,062 (337)
Extensive microscale N isotopic heterogeneity in chondritic organic matter [PDF]
, 2005 Introduction: H and N isotopic anomalies (mainly excesses of D and 15N) in organic matter from primitive meteorites and IDPs suggest preservation of presolar molecular cloud material [1-3].
Alexander, C. M. O'D. +4 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Moving data into and out of an institutional repository: Off the map and into the territory [PDF]
, 2007 Given the recent proliferation of institutional repositories, a key strategic question is how multiple institutions - repositories, archives, universities and others—can best work together to manage and preserve research data.
Bishop, Libby
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Who Cares About 3D Preservation?
IASSIST Quarterly, 2017 Preservation of 3D research data is a present and emerging need. An increasing number of researchers are generating, capturing and/or analyzing 3D data, but are rarely focused on preservation or reuse. This paper and presentation will describe models of
Jennifer Moore, Hannah Scates Kettler
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Towards Support for Long-Term Digital Preservation in Product Life Cycle Management
International Journal of Digital Curation, 2011 Important legal and economic motivations exist for the design and engineering industry to address and integrate digital long-term preservation into product life cycle management (PLM). Investigations revealed that it is not sufficient to archive only the
Wolfgang Wilkes +5 more
doaj +1 more source
Invest to Save: Report and Recommendations of the NSF-DELOS Working Group on Digital Archiving and Preservation [PDF]
, 2003 Digital archiving and preservation are important areas for research and development, but there is no agreed upon set of priorities or coherent plan for research in this area.
Ashley, K. +9 more
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source