Results 81 to 90 of about 131,444 (236)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Laser welding properties of 1800 MPa press hardening steel and low-alloy high-strength steel CR340LA

工程科学学报, 2020
A laser tailor welding experiment of 1800 MPa press hardening steel and low-alloy high-strength steel CR340LA was carried out using an optical fiber laser.
Wen LIANG, Bin FENG, Guo-ming ZHU, Yong-lin KANG, Li LIN, Reng-dong LIU   +5 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

High-temperature deformation behavior and constitutive relationship of press-hardening steel 38MnB5

工程科学学报, 2019
With the rapid development of global economy, problems in energy production and environmental protection are becoming severe, and the automotive industry is under increasing pressure to reduce the weight of vehicles and improve crash performance.
LIN Li, LI Bao-shun, ZHU Guo-ming, KANG Yong-lin, LIU Ren-dong   +4 more
doaj   +1 more source

Effect of ball milling time on microstructure and mechanical properties of ultrafine- grained Mg-3Al-Zn alloy prepared by powder metallurgy

Cailiao gongcheng, 2020
The ultrafine-grained Mg-3Al-Zn alloy was prepared by high energy ball milling,cold vacuum press and warm extrusion. The influence of ball milling time on the microstructure and mechanical properties of the alloy was studied. The results show that Al and
FANG Wa, LI Ji-guang, DU Zheng-yong
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

RESEARCH ON INCREASING ACTIVE LIFE OF CUTTING TOOLS [PDF]

Fiabilitate şi Durabilitate, 2012
At the exploitation of dies the defections that occur, due mainly to non operating rules of exploration, the improperly conditions of the machine (press) in terms of cinematic precision and the wearing elements in relative motion (ram displacement ...
Alin STĂNCIOIU, Florin-Cristian CIOFU
doaj  

Molecular dynamics simulations of glassy polymers

, 2009
We review recent results from computer simulation studies of polymer glasses, from chain dynamics around the glass transition temperature Tg to the mechanical behaviour below Tg.
Agapov, Aichele, Aichele, Alba-Simionesco, Alcoutlabi, Alexey Lyulin, Alexiadis, Andreanov, Angell, Angell, Baljon, Baljon, Baschnagel, Baschnagel, Bennemann, Bernabei, Bernabei, Berriot, Berthier, Berthier, Binder, Binder, Binder, Binder, Bohme, Boyce, Brodeck, Brüning, Buchholz, Bulacu, Bunker, Cavallo, Chaudhuri, Chen, Chong, Chong, Chopra, Chow, Colmenero, Colmenero, Colmenero, Colmenero, de Gennes, De Michele, Debenedetti, Ding, Dotson, Dudowicz, Ediger, Efremov, Ellison, Ellison, Fakhraai, Fakhraai, Fetters, Fetters, Flenner, Flenner, Foffi, Forrest, Forrest, Fredrickson, Fryer, Fuchs, Fukao, Fukao, Fukao, Gallo, Glotzer, Govaert, Granick, Grohens, Götze, Haward, Herminghaus, Herminghaus, Heuer, Hintermeyer, Hoy, Hoy, Hoy, Huth, Jain, Jain, Jain, Jean-Louis Barrat, Jörg Baschnagel, Keddie, Keys, Kim, Kim, Kob, Kob, Krakoviack, Krakoviack, Kramer, Krushev, Krushev, Kumar, Kunal, Lee, Likhtman, Lipson, Lobe, Lodge, Long, Lund, Lupaşcu, Lyulin, Lyulin, Lyulin, Lyulin, Lyulin, Lyulin, Makke, Manias, Mansfield, Mayer, Mayr, McCarty, McCoy, McKechnie, McLeish, Merabia, Merabia, Metatla, Meyer, Meyer, Meyer, Meyer, Mittal, Montes, Moreno, Moreno, Moreno, Morita, Murtola, Muthukumar, Müller-Plathe, Napolitano, Napolitano, Narros, Ngai, Oleinik, Papakonstantopoulos, Papakonstantopoulos, Papakonstantopoulos, Paul, Paul, Peter, Peter, Peter, Peter, Peter, Peter, Peter, Priestley, Riggleman, Riggleman, Riggleman, Riggleman, Riggleman, Rottler, Rottler, Rottler, Rottler, Rottler, Salamatina, Sarva, Scheidler, Scheidler, Scheidler, Schweizer, Serghei, Serghei, Servantie, Sharp, Signorini, Smith, Smith, Smith, Sokolov, Soldera, Sperl, Starr, Starr, Strauch, Sundararajan, Szamel, Tanguy, Teboul, Theodorou, Torres, Truskett, Tsalikis, Tsamados, Tsui, Utz, Vallee, Vallee, van Melick, van Melick, Van Workum, Varnik, Varnik, Varnik, Varnik, Vettorel, Vogel, Voigtmann, Vollmayr, Vollmayr, Vorselaars, Vorselaars, Warren, Wittmer, Xu, Yamamoto, Yan, Yoshimoto, Yoshimoto, Yoshimoto, Zaccarelli, Zamponi   +223 more
core   +3 more sources