Results 111 to 120 of about 87,423 (320)

Activity-dependence of synaptic vesicle dynamics [PDF]

, 2017
The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Forte, Luca A, Gramlich, Michael W, Klyachko, Vitaly A   +2 more
core   +2 more sources

Harnessing Time‐Dependent Magnetic Texture Dynamics via Spin‐Orbit Torque for Physics‐Enhanced Neuromorphic Computing

Advanced Science, EarlyView.
A neuromorphic computing platform using spin‐orbit torque‐controlled magnetic textures is reported. The device implements bio‐inspired synaptic functions and achieves high performance in both pattern recognition (>93%) and combinatorial optimization (>95%), enabling unified processing of cognitive and optimization tasks.
Yifan Zhang, Yu Li, Huai Lin, Xinying Wang, Long Liu, Guoliang Xing, Di Wang, Zhihao Zhao, Zhipeng Guo, Junbo Yang, Jiebin Niu, Yan Sun, Tom Wu, Guozhong Xing   +13 more
wiley   +1 more source

Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia

Frontiers in Cellular Neuroscience, 2015
Homocysteine (HCY) is a pro-inflammatory sulphur-containing redox active endogenous amino acid, which concentration increases in neurodegenerative disorders including amyotrophic lateral sclerosis (ALS).
Ellya eBukharaeva, Ellya eBukharaeva, Anastasia eShakirzyanova, Anastasia eShakirzyanova, Venera eKhuzakhmetova, Guzel eSitdikova, Rashid eGiniatullin, Rashid eGiniatullin   +7 more
doaj   +1 more source

Presynaptic A2A adenosine receptors dampen CB1 cannabinoid receptor-mediated inhibition of corticostriatal glutamatergic transmission [PDF]

, 2014
Background and Purpose Both CB1 cannabinoid and A2A adenosine receptors (CB1Rs and A2ARs) control synaptic transmission at corticostriatal synapses, with great therapeutic importance for neurological and psychiatric disorders.
Alexander, Alexander, Alexander, Augusto, Bamford, Bolam, Brotchie, Burnstock, Carriba, Castillo, Cerri, Ciruela, Costenla, Cunha, Cunha, D'Alcantara, Di Filippo, Dunwiddie, El Manira, Ferreira, Ferreira, Ferré, Ferré, Fino, Flajolet, Franco, Franco, Fredholm, Gerdeman, Goldman-Rakic, Gomes, Gomes, Graybiel, Grimsey, Gylys, Justinová, Justinová, Katona, Kilkenny, Kreitzer, Köfalvi, Ledent, Ledent, Lerner, Lopes, Lovinger, Marques, Martíre, McGrath, Melis, Nagayama, Nakano, Navizet, Pankratov, Pawson, Pinna, Quiroz, Rebola, Rebola, Rossi, Schiffmann, Schmid, Schulz, Sebastião, Sebastião, Shen, Shen, Shen, Soria, Sperlágh, Svenningsson, Tozzi, Uchigashima, Wieraszko, Yao, Yin   +75 more
core   +2 more sources

AN EFFECT OF POSTSYNAPTIC NEURONS UPON PRESYNAPTIC TERMINALS [PDF]

Proceedings of the National Academy of Sciences, 1969
Centrifugal (“antidromic”) discharges in cat sensory fibers are observed consistently in a variety of experimental preparations and with many different surgical and recording techniques. As is well known, they can be either “spontaneous” or induced by afferent volleys in other sensory fibers.
openaire   +2 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons

Neural Plasticity, 2013
The periaqueductal gray (PAG) is involved in the central regulation of nociceptive transmission by affecting the descending inhibitory pathway. In the present study, we have addressed the functional role of presynaptic glycine receptors in spontaneous ...
Kwi-Hyung Choi, Michiko Nakamura, Il-Sung Jang   +2 more
doaj   +1 more source

Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]

, 2009
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang, Lester, Henry A., McIntosh, J. Michael, McKinney, Sheri, Nashmi, Raad, Xiao, Cheng   +5 more
core  

Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse [PDF]

, 2019
In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs ...
Elgoyhen, Ana Belen, Katz, Eleonora, Kearney, Graciela Inés, Vattino, Lucas Gabriel, Wedemeyer, Carolina, Zorrilla de San Martín, Javier   +5 more
core   +1 more source

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source