Results 41 to 50 of about 87,423 (320)

Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix [PDF]

Journal of Neuroscience, 2007
Presynaptic terminals are specialized for mediating rapid fusion of synaptic vesicles (SVs) after calcium influx. The regulated trafficking of SVs likely results from a highly organized cytomatrix. How this cytomatrix links SVs, maintains them near the active zones (AZs) of release, and organizes docked SVs at the release sites is not fully understood.
Léa, Siksou, Philippe, Rostaing, Jean-Pierre, Lechaire, Thomas, Boudier, Toshihisa, Ohtsuka, Anna, Fejtová, Hung-Teh, Kao, Paul, Greengard, Eckart D, Gundelfinger, Antoine, Triller, Serge, Marty   +10 more
openaire   +2 more sources

Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.

PLoS ONE, 2017
Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina.
Iris Haumann, Dirk Junghans, Max Anstötz, Michael Frotscher   +3 more
doaj   +1 more source

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

eLife, 2018
Presynaptic neuronal activity requires the localization of thousands of proteins that are typically synthesized in the soma and transported to nerve terminals.
Matthew S Scarnati, Rahul Kataria, Mohana Biswas, Kenneth G Paradiso   +3 more
doaj   +1 more source

Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs [PDF]

, 2009
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development.
Elgoyhen, Ana Belen, Murthy, Vidya, Taranda, Julian, Vetter, Douglas E.   +3 more
core   +1 more source

Presynaptic facilitation at the crayfish neuromuscular junction: Role of calcium-activated potassium conductance [PDF]

, 1991
Membrane potential was recorded intracellularly near presynaptic terminals of the excitor axon of the crayfish opener neuromuscular junction (NMJ), while transmitter release was recorded postsynaptically.
Bittner, George D., Brodwick, Malcolm S., Sivaramakrishnan, Shobhana   +2 more
core   +1 more source

Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2

Frontiers in Neuroscience, 2017
Chronic exposure to alcohol produces adaptations within the basolateral amygdala (BLA) that are associated with the development of anxiety-like behaviors during withdrawal.
Dominic A. Gioia, Nancy Alexander, Brian A. McCool   +2 more
doaj   +1 more source

Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain

Acta Neuropathologica Communications, 2023
Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood.
Wenzhang Wang, Fanpeng Zhao, Yubing Lu, Sandra L. Siedlak, Hisashi Fujioka, Hao Feng, George Perry, Xiongwei Zhu   +7 more
doaj   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons.

PLoS ONE, 2014
Calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mDA) neurons in the striatum. However, calcium transients within mDA axons and axon terminals are difficult to study and little is known about how they are regulated ...
Carmelo Sgobio, David A Kupferschmidt, Guohong Cui, Lixin Sun, Zheng Li, Huaibin Cai, David M Lovinger   +6 more
doaj   +1 more source

The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Fragile X Syndrome and Hereditary Spastic Paraplegias

Frontiers in Molecular Neuroscience, 2016
The capacity of the nervous system to generate neuronal networks relies on the establishment and maintenance of synaptic contacts. Synapses are composed of functionally different presynaptic and postsynaptic compartments.
Felipe Bodaleo, Felipe Bodaleo, Christian Gonzalez-Billault, Christian Gonzalez-Billault, Christian Gonzalez-Billault   +4 more
doaj   +1 more source