Results 21 to 30 of about 51,824 (254)

The Molecular Architecture of Ribbon Presynaptic Terminals [PDF]

Molecular Neurobiology, 2009
The primary receptor neurons of the auditory, vestibular, and visual systems encode a broad range of sensory information by modulating the tonic release of the neurotransmitter glutamate in response to graded changes in membrane potential. The output synapses of these neurons are marked by structures called synaptic ribbons, which tether a pool of ...
George, Zanazzi, Gary, Matthews
openaire   +2 more sources

Invaginating Structures in Mammalian Synapses

Frontiers in Synaptic Neuroscience, 2018
Invaginating structures at chemical synapses in the mammalian nervous system exist in presynaptic axon terminals, postsynaptic spines or dendrites, and glial processes. These invaginating structures can be divided into three categories.
Ronald S. Petralia, Ya-Xian Wang, Mark P. Mattson, Pamela J. Yao   +3 more
doaj   +1 more source

Presynaptic inhibition of dopamine neurons controls optimistic bias

eLife, 2021
Regulation of reward signaling in the brain is critical for appropriate judgement of the environment and self. In Drosophila, the protocerebral anterior medial (PAM) cluster dopamine neurons mediate reward signals. Here, we show that localized inhibitory
Nobuhiro Yamagata, Takahiro Ezaki, Takahiro Takahashi, Hongyang Wu, Hiromu Tanimoto   +4 more
doaj   +1 more source

MicroRNAs in the axon and presynaptic nerve terminal [PDF]

Frontiers in Cellular Neuroscience, 2013
The distal structural/functional domains of the neuron, to include the axon and presynaptic nerve terminal, contain a large, heterogeneous population of mRNAs and an active protein synthetic system. These local components of the genetic expression machinery play a critical role in the development, function, and long-term viability of the neuron.
Kaplan, B.B., Kar, A.N., Gioio, A.E., Aschrafi, A.   +3 more
openaire   +5 more sources

Stimulation-induced differential redistributions of clathrin and clathrin-coated vesicles in axons compared to soma/dendrites

Molecular Brain, 2020
Clathrin-mediated endocytosis plays an important role in the recycling of synaptic vesicle in presynaptic terminals, and in the recycling of transmitter receptors in neuronal soma/dendrites.
Jung-Hwa Tao-Cheng
doaj   +1 more source

Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat. [PDF]

PLoS ONE, 2012
Abnormalities of striatal glutamate neurotransmission may play a role in the pathophysiology of Parkinson's disease and may respond to neurosurgical interventions, specifically stimulation or lesioning of the subthalamic nucleus (STN).
Ruth H Walker, Cindy Moore, Georgia Davies, Lisa B Dirling, Rick J Koch, Charles K Meshul   +5 more
doaj   +1 more source

Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals

Cell Reports, 2016
Summary: A common step in the formation of neural circuits is the conversion of growth cones to presynaptic terminals. Characterizing patterns of global gene expression during this process is problematic due to the cellular diversity of the brain and the
Kelvin Xi Zhang, Liming Tan, Matteo Pellegrini, S. Lawrence Zipursky, Jason M. McEwen   +4 more
doaj   +1 more source

Capsaicin-Induced Endocytosis of Endogenous Presynaptic CaV2.2 in DRG-Spinal Cord Co-Cultures Inhibits Presynaptic Function

Function, 2023
The N-type calcium channel, CaV2.2 is key to neurotransmission from the primary afferent terminals of dorsal root ganglion (DRG) neurons to their postsynaptic targets in the spinal cord.
Krishma H Ramgoolam, Annette C Dolphin
doaj   +1 more source

Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy

Translational Neurodegeneration, 2022
Background Axonal degeneration and defects in neuromuscular neurotransmission represent a pathological hallmark in spinal muscular atrophy (SMA) and other forms of motoneuron disease.
Chunchu Deng, Sebastian Reinhard, Luisa Hennlein, Janna Eilts, Stefan Sachs, Sören Doose, Sibylle Jablonka, Markus Sauer, Mehri Moradi, Michael Sendtner   +9 more
doaj   +1 more source

Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.

PLoS ONE, 2017
Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina.
Iris Haumann, Dirk Junghans, Max Anstötz, Michael Frotscher   +3 more
doaj   +1 more source