Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation
Cell Reports, 2016 Here, we uncover a mechanism for regulating the number of active presynaptic GABAB receptors (GABABRs) at nerve terminals, an important determinant of neurotransmitter release.
Saad Hannan +2 more
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Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease [PDF]
Frontiers in Molecular Neuroscience, 2023 Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the huntingtin gene, which encodes the mutant huntingtin protein containing an ...
Chen Xu +10 more
doaj +2 more sources
Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals. [PDF]
Exp Mol Med, 2021 AbstractNeddylation is a posttranslational modification in which NEDD8 is conjugated to a target substrate by cellular processes similar to those involved in ubiquitination. Recent studies have identified PSD-95 and cofilin as substrates for neddylation in the brain and have shown that neddylation modulates the maturation and stability of dendritic ...
Kang M +6 more
europepmc +4 more sources
Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington’s Disease [PDF]
Frontiers in Molecular Neuroscience, 2018 Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the huntingtin (HTT) gene, which leads to progressive loss of neurons starting in the striatum and cortex.
Sidong Chen +8 more
doaj +2 more sources
Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals [PDF]
Cell Reports, 2017 Localized protein synthesis is a mechanism for developing axons to react acutely and in a spatially restricted manner to extracellular signals. As such, it is important for many aspects of axonal development, but its role in the formation of presynapses ...
Andreia F.R. Batista +2 more
doaj +2 more sources
Presynaptic chloride-dependent regulation of spontaneous glutamate release in the rat medial preoptic nucleus [PDF]
Frontiers in Cellular NeuroscienceNeurosteroids and inhibitory neurotransmitters can modulate neurotransmitter release from presynaptic terminals, yet the mechanisms underlying such modulation remain unclear.
Mario Pérez-del-Pozo +3 more
doaj +2 more sources
Neurexin nanoclusters: A novel structure at presynaptic terminals. [PDF]
J Cell Biol, 2019 The trans-synaptic cell adhesion molecule neurexin regulates synaptic functions but its high-resolution subcellular localization and dynamics were unknown. Trotter et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201812076) describe previously unrecognized nanoscale clusters of neurexin-1 in presynaptic terminals and their regulation by ADAM10 ...
Kawaguchi D, Gotoh Y.
europepmc +4 more sources
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals [PDF]
Journal of Cell Biology, 2021 Matthew J Zunitch +2 more
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Distinct functional developments of surviving and eliminated presynaptic terminals [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Mitsuharu Midorikawa +2 more
exaly +2 more sources
Parkinsonism with Normal Dopaminergic Presynaptic Terminals in Cerebrotendinous Xanthomatosis [PDF]
Movement Disorders Clinical Practice, 2020 Qi Yang, Shu-Ying Liu, Piú Chan
exaly +2 more sources