Results 31 to 40 of about 51,824 (254)

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

eLife, 2018
Presynaptic neuronal activity requires the localization of thousands of proteins that are typically synthesized in the soma and transported to nerve terminals.
Matthew S Scarnati, Rahul Kataria, Mohana Biswas, Kenneth G Paradiso   +3 more
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons.

PLoS ONE, 2014
Calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mDA) neurons in the striatum. However, calcium transients within mDA axons and axon terminals are difficult to study and little is known about how they are regulated ...
Carmelo Sgobio, David A Kupferschmidt, Guohong Cui, Lixin Sun, Zheng Li, Huaibin Cai, David M Lovinger   +6 more
doaj   +1 more source

The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Fragile X Syndrome and Hereditary Spastic Paraplegias

Frontiers in Molecular Neuroscience, 2016
The capacity of the nervous system to generate neuronal networks relies on the establishment and maintenance of synaptic contacts. Synapses are composed of functionally different presynaptic and postsynaptic compartments.
Felipe Bodaleo, Felipe Bodaleo, Christian Gonzalez-Billault, Christian Gonzalez-Billault, Christian Gonzalez-Billault   +4 more
doaj   +1 more source

Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain

Acta Neuropathologica Communications, 2023
Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood.
Wenzhang Wang, Fanpeng Zhao, Yubing Lu, Sandra L. Siedlak, Hisashi Fujioka, Hao Feng, George Perry, Xiongwei Zhu   +7 more
doaj   +1 more source

Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2

Frontiers in Neuroscience, 2017
Chronic exposure to alcohol produces adaptations within the basolateral amygdala (BLA) that are associated with the development of anxiety-like behaviors during withdrawal.
Dominic A. Gioia, Nancy Alexander, Brian A. McCool   +2 more
doaj   +1 more source

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. [PDF]

PLoS Biology, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Ceng Luo, Vijayan Gangadharan, Kiran Kumar Bali, Rou-Gang Xie, Nitin Agarwal, Martina Kurejova, Anke Tappe-Theodor, Irmgard Tegeder, Susanne Feil, Gary Lewin, Erika Polgar, Andrew J Todd, Jens Schlossmann, Franz Hofmann, Da-Lu Liu, San-Jue Hu, Robert Feil, Thomas Kuner, Rohini Kuner   +18 more
doaj   +1 more source

Axon terminals control endolysosome diffusion to support synaptic remodelling

Life Science Alliance, 2021
Endolysosomes present in the presynaptic terminal move by diffusion constrained by F-actin and increase their mobility during the remodelling of synaptic connectivity to support a local degradative activity.
Beatrice Terni, Artur Llobet
doaj   +1 more source

Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion. [PDF]

PLoS ONE, 2013
The calyx-type synapse of chick ciliary ganglion (CG) has been intensively studied for decades as a model system for the synaptic development, morphology and physiology.
Ryo Egawa, Shoko Hososhima, Xubin Hou, Hidetaka Katow, Toru Ishizuka, Harukazu Nakamura, Hiromu Yawo   +6 more
doaj   +1 more source

Presynaptic Acetylcholine Receptors Modulate the Time Course of Action Potential-Evoked Acetylcholine Quanta Secretion at Neuromuscular Junctions

Biomedicines, 2022
For effective transmission of excitation in neuromuscular junctions, the postsynaptic response amplitude must exceed a critical level of depolarization to trigger action potential spreading along the muscle-fiber membrane.
Ellya A. Bukharaeva, Andrey I. Skorinkin, Dmitry V. Samigullin, Alexey M. Petrov   +3 more
doaj   +1 more source