Results 41 to 50 of about 51,824 (254)

Molecular Nanomachines of the Presynaptic Terminal

Frontiers in Synaptic Neuroscience, 2016
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders.
Silvio O Rizzoli, Lucia Tabares
  +6 more sources

A role for GAT-1 in Presynaptic GABA Homeostasis?

Frontiers in Cellular Neuroscience, 2011
In monoamine-releasing terminals, neurotransmitter transporters – in addition to terminating synaptic transmission by clearing released transmitters from the extracellular space - are the primary mechanism for replenishing transmitter stores and thus ...
Fiorenzo eConti, Fiorenzo eConti, Marcello eMelone, Giorgia eFattorini, Luca eBragina, Silvia eCiappelloni   +5 more
doaj   +1 more source

Regulation of synaptic vesicle docking by different classes of macromolecules in active zone material. [PDF]

PLoS ONE, 2012
The docking of synaptic vesicles at active zones on the presynaptic plasma membrane of axon terminals is essential for their fusion with the membrane and exocytosis of their neurotransmitter to mediate synaptic impulse transmission.
Joseph A Szule, Mark L Harlow, Jae Hoon Jung, Francisco F De-Miguel, Robert M Marshall, Uel J McMahan   +5 more
doaj   +1 more source

Facilitation of neocortical presynaptic terminal development by NMDA receptor activation

Neural Development, 2012
Background Neocortical circuits are established through the formation of synapses between cortical neurons, but the molecular mechanisms of synapse formation are only beginning to be understood.
Sceniak Michael P, Berry Corbett T, Sabo Shasta L   +2 more
doaj   +1 more source

Photooxidation-guided ultrastructural identification and analysis of cells in neuronal tissue labeled with green fluorescent protein. [PDF]

PLoS ONE, 2013
The ultrastructural characterization of neuronal compartments in intact tissue labeled with green fluorescent protein (GFP) remains a frequently encountered challenge, despite work establishing photooxidation of GFP in cultured cells.
Heinz Horstmann, Mariya Vasileva, Thomas Kuner   +2 more
doaj   +1 more source

The role of activity in synaptic degeneration in a protein misfolding disease, prion disease. [PDF]

PLoS ONE, 2012
In chronic neurodegenerative diseases associated with aggregates of misfolded proteins (such as Alzheimer's, Parkinson's and prion disease), there is an early degeneration of presynaptic terminals prior to the loss of the neuronal somata. Identifying the
Matteo Caleo, Laura Restani, Eleonora Vannini, Zuzana Siskova, Hussain Al-Malki, Ruth Morgan, Vincent O'Connor, V Hugh Perry   +7 more
doaj   +1 more source

Glutamate-Dependent Stabilization of Presynaptic Terminals [PDF]

Neuron, 2003
Dissecting the mechanisms underlying synapse formation and elimination is fundamental to understand how the nervous system is constructed and subsequently modified. Two studies by Tashiro et al. and by Hashimoto and Kano in this issue of Neuron provide new insights into the roles of neurotransmitter glutamate release in regulating the motility of ...
openaire   +2 more sources

Sharing vesicles between central presynaptic terminals: implications for synaptic function

Frontiers in Synaptic Neuroscience, 2010
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance.
Kevin Staras, Tiago Branco, Tiago Branco
doaj   +1 more source

Dual pools of actin at presynaptic terminals

Journal of Neurophysiology, 2012
We investigated actin's function in vesicle recycling and exocytosis at lamprey synapses and show that FM1-43 puncta and phalloidin-labeled filamentous actin (F-actin) structures are colocalized, yet recycling vesicles are not contained within F-actin clusters. Additionally, phalloidin also labels a plasma membrane-associated cortical actin.
Adam, Bleckert, Huzefa, Photowala, Simon, Alford   +2 more
openaire   +3 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source