Biophysical constraints of optogenetic inhibition at presynaptic terminals. [PDF]
Nat Neurosci, 2016 We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained archaerhodopsin activation was paradoxically associated
Mahn M +4 more
europepmc +5 more sources
Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion. [PDF]
PLoS ONE, 2013 The calyx-type synapse of chick ciliary ganglion (CG) has been intensively studied for decades as a model system for the synaptic development, morphology and physiology.
Ryo Egawa +6 more
doaj +1 more source
Biomedicines, 2022 For effective transmission of excitation in neuromuscular junctions, the postsynaptic response amplitude must exceed a critical level of depolarization to trigger action potential spreading along the muscle-fiber membrane.
Ellya A. Bukharaeva +3 more
doaj +1 more source
Photooxidation-guided ultrastructural identification and analysis of cells in neuronal tissue labeled with green fluorescent protein. [PDF]
PLoS ONE, 2013 The ultrastructural characterization of neuronal compartments in intact tissue labeled with green fluorescent protein (GFP) remains a frequently encountered challenge, despite work establishing photooxidation of GFP in cultured cells.
Heinz Horstmann +2 more
doaj +1 more source
Review: Dystroglycan in the Nervous System [PDF]
, 2007 Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core +2 more sources
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. [PDF]
PLoS Biology, 2012 Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Ceng Luo +18 more
doaj +1 more source
A role for GAT-1 in Presynaptic GABA Homeostasis?
Frontiers in Cellular Neuroscience, 2011 In monoamine-releasing terminals, neurotransmitter transporters – in addition to terminating synaptic transmission by clearing released transmitters from the extracellular space - are the primary mechanism for replenishing transmitter stores and thus ...
Fiorenzo eConti +5 more
doaj +1 more source
Regulation of synaptic vesicle docking by different classes of macromolecules in active zone material. [PDF]
PLoS ONE, 2012 The docking of synaptic vesicles at active zones on the presynaptic plasma membrane of axon terminals is essential for their fusion with the membrane and exocytosis of their neurotransmitter to mediate synaptic impulse transmission.
Joseph A Szule +5 more
doaj +1 more source
Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]
, 2011 Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G. +5 more
core +1 more source
Kainate receptors in developing presynaptic terminals [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011 AbstractThe formation of neuronal circuitry involves a period of activity‐dependent fine‐tuning and maturation of the connectivity, during which some of the nascent synapses are strengthened and others are eliminated. Many of the mechanisms utilized in this process are developmentally downregulated and replaced with synaptic machinery typical of adult ...
Lauri Sari, Taira Tomi
openaire +1 more source