Results 91 to 100 of about 1,776 (189)

Bioorthogonal Chemistry for Pretargeted PET Imaging

, 2013
Positron Emission Tomography (PET) is emerging as a powerful method for imaging cancer through the design and development of new radiotracers. Antibodies have promising properties as ligands for targeting cancer, as they have the advantage of displaying high affinity for their respective receptors.
openaire   +3 more sources

Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes

Angewandte Chemie International Edition, Volume 64, Issue 5, January 27, 2025.
Highly reactive aryl‐tetrazines are widely used for fast bioorthogonal ligation. However, their application in click‐to‐release chemistry has been impeded by significantly limited release efficiency. To address this challenge, we introduced hydroxyl functionalities to direct and accelerate post‐click tautomerization, resulting in hydroxyaryl‐tetrazines
Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr, Andreas Löffler, Stefan Kronister, Andres Fernandez del Castillo, Marion Goldeck, Rastislav Dzijak, Michal Rahm, Milan Vrabel, Dennis Svatunek, Jonathan C. T. Carlson, Hannes Mikula   +13 more
wiley   +1 more source

Phospholipid Detection From Surgical Smoke Distinguishes Basal Cell Carcinoma: A Proof‐of‐Principle Study

Dermatologic Therapy, Volume 2025, Issue 1, 2025.
Background: Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer and the most common malignancy in Caucasians. Diagnostics and treatment of BCC cause significant health‐related stress for many patients and costs for public health care systems. Differential mobility spectrometry (DMS) is a sensitive method for detection of gaseous molecules.
Anni Salminen, Patrik Sioris, Juha Jernman, Nele Veide, Anton Kontunen, Meri Mäkelä, Markus Karjalainen, Minna Kelloniemi, Niku Oksala, Antti Roine, Ioannis D. Bassukas   +10 more
wiley   +1 more source

Conformationally Strained trans- Cyclooctene (sTCO) Enables the Rapid Construction of 18 F-PET Probes via Tetrazine Ligation [PDF]

, 2016
The bioorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the rapid construction of F-18 probes for PET imaging. Described here is a second generation 18F-labeling system based on a conformationally strained trans-cyclooctene ...
Fox, Joseph, Giglio, Ben, Li, Zibo, Liu, Yu, Rohlfing, Katarina, Svatunek, Dennis, Wang, Hui, Wang, Mengzhe, Wu, Zhanghong, Yuan, Hong   +9 more
core   +3 more sources

Advancements in colorectal cancer detection: The role of immuno‐positron emission tomography, immuno‐single‐photon emission computed tomography, and machine learning applications

Journal of Intelligent Medicine, Volume 1, Issue 1, Page 63-90, December 2024.
Abstract Colorectal cancer (CRC) ranks as the world's second most prevalent cancer and third in mortality. Detection and diagnosis are crucial in research and clinical settings. While colonoscopy and computed tomographic colonography are widely used for identifying organic lesions, positron emission tomography (PET) and single‐photon emission computed ...
Surui Chen, Xiumin Shi, Shu Liu, Pei Pei, Kai Yang, Lin Hu   +5 more
wiley   +1 more source

Pembuatan Radioisotop 64cu Berbasis Reaksi Nuklir 64ni (P,n) 64cu : Simulasi Preparasi Target dan Pemisahan Radionuklida [PDF]

, 2010
Dalam upayapenguasaan teknologi produksi radioisotop 64Cu berbasis reaksi nuklir 64Ni (p,n) 64Cu, targetnikel disiapkan melalui electroplating suasana asam larutan nikel klorida–asam borat danelectroplating suasana basa larutan nikel klorida–nikel sulfat
Soenarjo, S. (Sunarhadijoso), Sriyono, S. (Sriyono), Triyanto, T. (Triyanto), Y. Rahman, Wira Y   +3 more
core  

Tissue‐seeking dyes for in vivo applications

Smart Molecules, Volume 2, Issue 4, December 2024.
Fluorescent dyes that can selectively target and label specific tissues or cell types are very important in visualizing and monitoring biological processes in living organisms. This review provides an overview of the current state of tissue‐seeking dyes for in vivo applications. We discuss the design principles and chemical structures of dyes that have
Yuan Ma, Cuirong Qin, Yanlin Lei, Xiaodong Yang, Zuhai Lei   +4 more
wiley   +1 more source

Trans-cyclooctene—a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs

EJNMMI Radiopharmacy and Chemistry
Background Trans-cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand Diels–Alder reactions.
Karuna Adhikari, Maarten Vanermen, Gustavo Da Silva, Tim Van den Wyngaert, Koen Augustyns, Filipe Elvas   +5 more
doaj   +1 more source

New fluorine-18 pretargeting PET imaging by bioorthogonal chlorosydnone–cycloalkyne click reaction

Chemical Communications, 2019
A PET pretargeting approach using strain-promoted sydnone–alkyne cycloaddition.
Richard, Mylène, Truillet, Charles, Tran, Vu Long, Liu, Hui, Porte, Karine, Audisio, Davide, Roche, Mélanie, Jego, Benoit, Cholet, Sophie, Fenaille, François, Kuhnast, Bertrand, Taran, Frédéric, Specklin, Simon   +12 more
openaire   +4 more sources

Bispecific Antibody Pretargeting for Improving Cancer Imaging and Therapy [PDF]

, 2005
The main objective of this project was to evaluate pretargeting systems that use a bispecific antibody (bsMAb) to improve the detection and treatment of cancer. A bsMAb has specificity to a tumor antigen, which is used to bind the tumor, while the other specificity is to a peptide that can be radiolabeled.
openaire   +2 more sources