Results 51 to 60 of about 3,987,151 (271)

Pretreatment and Acquired Antiretroviral Drug Resistance Among Persons Living With HIV in Four African Countries [PDF]

Clinical Infectious Diseases, 2020
AbstractBackgroundEmerging HIV drug resistance (HIVDR) could jeopardize the success of standardized HIV management protocols in resource-limited settings. We characterized HIVDR among antiretroviral therapy (ART)-naive and experienced participants in the African Cohort Study (AFRICOS).MethodsFrom January 2013 to April 2019, adults with HIV-1 RNA & ...
Trevor A Crowell, Brook Danboise, Ajay Parikh, Allahna Esber, Nicole Dear, Peter Coakley, Alex Kasembeli, Jonah Maswai, Samoel Khamadi, Emmanuel Bahemana, Michael Iroezindu, Francis Kiweewa, John Owuoth, Joanna Freeman, Linda L Jagodzinski, Jennifer A Malia, Leigh Ann Eller, Sodsai Tovanabutra, Sheila A Peel, Julie A Ake, Christina S Polyak   +20 more
openaire   +2 more sources

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo [PDF]

, 2022
Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men globally. Despite improvements in the diagnosis and treatment of PCa, a significant proportion of patients with high-risk localized disease and all patients with ...
Wakimian, Kevork, Zahwe, Amin, Mukherji, Deborah, Mukherji, Deborah M., Yehya, Amani, Zeid, Yousef, Abou-Kheir, Wassim G., Ghamlouche, Fatima, Abou-Kheir, Wassim   +8 more
core   +1 more source

National survey of pre-treatment HIV drug resistance in Cuban patients.

PLoS ONE, 2019
BACKGROUND:The World Health Organization (WHO) recommends a method to estimate nationally representative pretreatment HIV drug resistance (PDR) in order to evaluate the effectiveness of first -line treatments.
Liuber Y Machado, Madeline Blanco, Laura S López, Héctor M Díaz, Marta Dubed, Neisy Valdés, Enrique Noa, Liodelvio Martínez, María T Pérez, Dania M Romay, Caridad B Rivero, José Joanes, Isis Cancio, María I Lantero, Mireida Rodríguez   +14 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Drug resistance maps to guide intermittent preventive treatment of malaria in African infants. [PDF]

, 2011
Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is not compromised by
CALLY ROPER, Naidoo, Inbarani, Roper, Cally, INBARANI NAIDOO   +3 more
core   +1 more source

Prevalence and transmission of pretreatment drug resistance and acquired drug resistance among people living with HIV-1 in Chongqing, China, 2014–2024

Frontiers in Public Health
ObjectivesTo explore the epidemic trends of pretreatment drug resistance (PDR) and acquired drug resistance (ADR) among people living with HIV (PLWH) from 2014 to 2024 in Chongqing, China.MethodsSamples and clinical data of PLWH were collected from 2014 ...
Wenwan Gao, Jungang Li, Mei Li, Kun He, Renni Deng, Kun Yang   +5 more
doaj   +1 more source

Moderate Levels of Pretreatment HIV Drug Resistance — Zimbabwe, April–July 2015 [PDF]

Open Forum Infectious Diseases, 2017
Abstract Background The World Health Organization (WHO) HIV Drug Resistance (HIVDR) report 2012 demonstrated that the levels of HIVDR to first-line antiretroviral therapy (ART) are increasing. This finding threatens to reverse a decade of gains in HIV/AIDS epidemic control.
Da Silva, Juliana, Dzangare, Janet, Gonese, Elizabeth, Mhangara, Mutsa, Mugurungi, Owen, Barr, Beth, Lloyd, Spencer, Raizes, Elliot   +7 more
openaire   +1 more source

Protease and gag diversity and drug resistance mutations among treatment-naive Mexican people living with HIV

BMC Infectious Diseases, 2022
Introduction In Mexico, HIV genotyping is performed in people living with HIV (PLWH) failing their first-line antiretroviral (ARV) regimen; it is not routinely done for all treatment-naive PLWH before ARV initiation.
Samantha Climaco-Arvizu, Víctor Flores-López, Carolina González-Torres, Francisco Javier Gaytán-Cervantes, María Concepción Hernández-García, Paola Berenice Zárate-Segura, Monserrat Chávez-Torres, Emiliano Tesoro-Cruz, Sandra María Pinto-Cardoso, Vilma Carolina Bekker-Méndez   +9 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source