Results 41 to 50 of about 3,987,151 (271)

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

Kanamycin and Ofloxacin Activate the Intrinsic Resistance to Multiple Antibiotics in Mycobacterium smegmatis

Biology, 2023
Drug resistance (DR) in Mycobacterium tuberculosis is the main problem in fighting tuberculosis (TB). This pathogenic bacterium has several types of DR implementation: acquired and intrinsic DR.
Aleksey A. Vatlin, Olga B. Bekker, Kirill V. Shur, Rustem A. Ilyasov, Petr A. Shatrov, Dmitry A. Maslov, Valery N. Danilenko   +6 more
doaj   +1 more source

HIV pretreatment drug resistance among cisgender MSM and transgender women from Lima, Peru. [PDF]

J Int AIDS Soc, 2019
AbstractIntroductionTransmitted, or any pretreatment drug resistance (TDR, PDR) can compromise efficacy of first‐line antiretroviral therapy (ART). In Peru, genotypic resistance testing is not routinely performed before ART initiation, and estimated PDR prevalence prior to 2012 ranged from 1.0% to 4.7%. We aimed to update estimates of PDR prevalence in
Trebelcock WL, Lama JR, Duerr A, Sanchez H, Cabello R, Gilada T, Segura P, Reisner SL, Mayer KH, Mullins J, Bender Ignacio RA.   +10 more
europepmc   +4 more sources

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2016
Objectives The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. Methods Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Kelner, Anna, Fairlamb, Alan; id_orcid, Berriman, Matthew, Foth, Bernado J., Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +1 more source

Pretreatment HIV Drug Resistance and Virologic Outcomes to First-Line Antiretroviral Therapy in Peru [PDF]

AIDS Research and Human Retroviruses, 2019
Access to nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) first-line antiretroviral therapy (ART) for HIV has been increasing in Peru since a national ART program was initiated in 2004.
Jaime, Soria, Raquel, Mugruza, Molly, Levine, Segundo R, León, Jorge, Arévalo, Eduardo, Ticona, Ingrid A, Beck, Lisa M, Frenkel   +7 more
openaire   +2 more sources

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]

, 2004
Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR, Story, A, Hayward, AC, Watson, JM, Conaty, SJ, Drobniewski, FA   +5 more
core   +1 more source

Prevalence of pretreatment HIV drug resistance in Cameroon following a nationally representative WHO survey [PDF]

Journal of Antimicrobial Chemotherapy, 2018
Pretreatment HIV drug resistance (PDR) has the potential to affect treatment outcome and mortality. We present here the first nationally representative PDR study conducted in Cameroon.From February to July 2015, HIV-infected ART initiators were recruited from 24 randomly selected clinics situated in both urban and rural regions.
Gaëlle F Tchouwa, Sabrina Eymard-Duvernay, Amandine Cournil, Nadine Lamare, Laetitia Serrano, Christelle Butel, Silvia Bertagnolio, Eitel Mpoudi-Ngole, Elliot Raizes, Avelin F Aghokeng, Sylvie Abia, Avelin Fobang Aghokeng, Silvia Bertagnolio, Dorothée Bessala, Christelle Butel, Corneluis Chebo, Oumarou Chifen, Amandine Cournil, John E Ebonloe, Sabrina Eymard-Duvernay, Gaspary Fodjeu, Suzanne Izard, Brigitte Kamtie, Emmanuel Chia Kiawi, Charles Kouam, Charles Kouanfack, Nadine Lamare, Emilienne Mamang, Nadia Mandeng, Eyongetah Mbu, Bouba Mfokue, Jembia Joseph Mosoko, Bernard Nandjou, Mireille Mpoudi, Eitel Mpoudi-Ngole, Mariama Ndam, Anne Njom Nlend, Batam Nlend, Cecile Nouboué, Pierrette Omgba, Thierry Owono, Florant Oyono, Ida Penda, Elliot Raizes, Laetitia Serrano, Xavier Tchetnya, Christian Tchinou, Gaëlle Francine Tchouwa   +47 more
openaire   +2 more sources

Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea [PDF]

, 2012
: BACKGROUND: Monitoring drug resistance in Mycobacterium tuberculosis is essential to curb the spread of tuberculosis (TB). Unfortunately, drug susceptibility testing is currently not available in Papua New Guinea (PNG) and that impairs TB control in ...
Gagneux, S., Siba Peter, Beck, H. P., Hans-Peter Beck, Beck Hans-Peter, Carter Robyn, Paul Harino, Harino, P., Carter, R., Serej Ley, Ley Serej, Siba, P., Gagneux Sebastien, Borrell Sonia, Coscolla Mireia, Mireia Coscolla, Ballif Marie, Stefan Niemann, Ley, S., Marie Ballif, Coulter, C., Robyn Carter, Coulter Christopher, Christopher Coulter, Ballif, M., Peter Siba, Niemann, S., Harino Paul, Niemann Stefan, Sebastien Gagneux, Phuanukoonnon, S., Borrell, S., Coscolla, M., Sonia Borrell, Suparat Phuanukoonnon, Phuanukoonnon Suparat   +35 more
core   +1 more source

Retrospective Study on Genetic Diversity and Drug Resistance among People Living with HIV at an AIDS Clinic in Beijing

Pharmaceuticals
(1) Background: The objective of this study was to investigate the prevalence of genetic diversity and drug resistance mutations among people living with HIV (PLWH) attending clinics in Beijing. (2) Methods: A retrospective analysis was conducted on PLWH
Yan-Ze Shi, Hui-Huang Huang, Xin-Hua Wang, Bing Song, Tian-Jun Jiang, Min-Rui Yu, Ze-Rui Wang, Rui-Ting Li, Yan-Mei Jiao, Xin Su, Fu-Sheng Wang   +10 more
doaj   +1 more source

Macrolide- and Rifampin-Resistant Rhodococcus equi on a Horse Breeding Farm, Kentucky, USA

Emerging Infectious Diseases, 2013
Macrolide and rifampin resistance developed on a horse breeding farm after widespread use was instituted for treatment of subclinical pulmonary lesions in foals.
Alexandra J. Burton, Steeve Giguère, Tracy L. Sturgill, Londa J. Berghaus, Nathan M. Slovis, Jeremy L. Whitman, Court Levering, Kyle R. Kuskie, Noah D. Cohen   +8 more
doaj   +1 more source