Results 21 to 30 of about 3,987,151 (271)

Patterns of pretreatment drug resistance mutations of very early diagnosed and treated infants in Botswana. [PDF]

AIDS, 2021
Objective: To describe the occurrence of HIV drug resistance mutations (DRMs) in both intact and defective HIV-1 cell-associated DNA (HIV-1 CAD) among early-treated infants. Design: The Botswana EIT Study (ClinicalTrials.gov NCT02369406) initiated antiretroviral therapy (ART) in the
Moraka NO, Garcia-Broncano P, Hu Z, Ajibola G, Bareng OT, Pretorius-Holme M, Maswabi K, Maphorisa C, Mohammed T, Gaseitsiwe S, VanZyl GU, Kuritzkes DR, Lichterfeld M, Moyo S, Shapiro RL.   +14 more
europepmc   +4 more sources

Impact of Next-generation Sequencing Defined Human Immunodeficiency Virus Pretreatment Drug Resistance on Virological Outcomes in the ANRS 12249 Treatment-as-Prevention Trial. [PDF]

Clin Infect Dis, 2019
Derache A, Iwuji CC, Baisley K, Danaviah S, Marcelin AG, Calvez V, de Oliveira T, Dabis F, Porter K, Pillay D.   +9 more
europepmc   +2 more sources

The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China [PDF]

Epidemiology and Infection, 2020
Abstract HIV-1 drug resistance can compromise the effectiveness of antiretroviral therapy (ART). A survey of pretreatment HIV-1 drug resistance (PDR) was conducted in Lincang Prefecture of Yunnan Province. From 372 people living with HIV/AIDS initiating ART for the first time during 2017–2018, 322 pol sequences were obtained, of which 11 HIV-1 ...
Min Chen, Qiongmei Zhu, Hui Xing, Huichao Chen, Xiaomei Jin, Lijuan Dong, Jie Dai, Min Yang, Cuiyun Yang, Manhong Jia, Yanling Ma   +10 more
openaire   +2 more sources

The Prevalence of Pretreatment Drug Resistance and Transmission Networks Among Newly Diagnosed HIV-1-Infected Individuals in Nanning, Guangxi, China. [PDF]

Pathogens
Su Q, Li Y, Huang T, Wei L, He J, Huang Y, Mo G, Qin J, Tao C, Huang X, Ye L, Liang H, Liang B, Huang J.   +13 more
europepmc   +2 more sources

Drivers of HIV-1 drug resistance to non-nucleoside reverse-transcriptase inhibitors (NNRTIs) in nine southern African countries: a modelling study

BMC Infectious Diseases, 2021
Introduction The rise of HIV-1 drug resistance to non-nucleoside reverse-transcriptase inhibitors (NNRTI) threatens antiretroviral therapy's long-term success (ART).
Julien Riou, Carole Dupont, Silvia Bertagnolio, Ravindra K. Gupta, Roger D. Kouyos, Matthias Egger, Christian L. Althaus   +6 more
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +5 more sources

High prevalence of pre-treatment HIV drug resistance in Papua New Guinea: findings from the first nationally representative pre-treatment HIV drug resistance study

BMC Infectious Diseases, 2022
Background Determining the prevalence of pre-treatment HIV drug resistance (PDR) is important to assess the effectiveness of first-line therapies. To determine PDR prevalence in Papua New Guinea (PNG), we conducted a nationally representative survey ...
Janet Gare, Ben Toto, Percy Pokeya, Linh-Vi Le, Nick Dala, Namarola Lote, Bangan John, Abel Yamba, Kevin Soli, Joshua DeVos, Heather Paulin, Nick Wagar, Du-Ping Zheng, Takeshi Nishijima, Peniel Boas, Angela Kelly-Hanku, Anup Gurung   +16 more
doaj   +1 more source

Prevalence of pretreatment HIV drug resistance in Mwanza, Tanzania [PDF]

Journal of Antimicrobial Chemotherapy, 2018
In a 2008-10 study, we found a pretreatment HIV drug resistance (PDR) prevalence of 18.2% in patients at Bugando Medical Centre (BMC) in Mwanza, Tanzania.To determine the prevalence of PDR and transmitted HIV drug resistance (TDR) in patients visiting the BMC from 2013 to 2015.Adult outpatients were sequentially enrolled into two groups, separated by ...
Rudovick, Ladius, Brauner, Jan M., Englert, Johanna, Seemann, Carolina, Plugaru, Karina, Kidenya, Benson R., Kalluvya, Samuel E., Scheller, Carsten, Kasang, Christa   +8 more
openaire   +3 more sources

Advancing HIV Drug Resistance Technologies and Strategies: Insights from South Africa’s Experience and Future Directions for Resource-Limited Settings

Diagnostics, 2023
Monitoring of HIV drug resistance (HIVDR) remains critical for ensuring countries attain and sustain the global goals for ending HIV as a public health threat by 2030. On an individual patient level, drug resistance results assist in ensuring unnecessary
Kim Steegen, Gert U. van Zyl, Mathilda Claassen, Aabida Khan, Melendhran Pillay, Subitha Govender, Phillip A. Bester, Johanna M. van Straaten, Vibha Kana, Ewaldé Cutler, Monalisa N. Kalimashe, Ramokone L. Lebelo, Mokopi B. H. Moloi, Lucia Hans   +13 more
doaj   +1 more source

Pretreatment HIV drug resistance among adults initiating ART in Namibia [PDF]

Journal of Antimicrobial Chemotherapy, 2018
Continued use of standardized, first-line ART containing NNRTIs and NRTIs may contribute to ongoing emergence of HIV drug resistance (HIVDR) in Namibia.A nationally representative cross-sectional survey was conducted during 2015-16 to estimate the prevalence of significant pretreatment HIV drug resistance (PDR) and viral load (VL) suppression rates 6 ...
Negussie, Taffa, Clay, Roscoe, Souleymane, Sawadogo, Michael, De Klerk, Andrew L, Baughman, Adam, Wolkon, Nicholus, Mutenda, Josh, DeVos, Du-Ping, Zheng, Nick, Wagar, Dimitri, Prybylski, Chunfu, Yang, Ndapewa, Hamunime, Simon, Agolory, Elliot, Raizes   +14 more
openaire   +2 more sources