Results 31 to 40 of about 3,987,151 (271)

Docetaxel as Salvage Therapy in Highly Pretreated and Drug Resistant Gastrointestinal Carcinomas [PDF]

Clinical medicine. Oncology, 2008
Introduction Despite many efforts to develop new chemotherapies for metastatic upper gastrointestinal (GI) cancer, overall prognosis continues to be fatal, particularly in gastric and pancreatic cancer. Many of these patients deserve second-or third-line treatment after failure of first-line chemotherapy ...
Martin F. Sprinzl, Sonia M. Wytopil, Anja Dahmen, Stephan Kanzler, Peter R. Galle, Markus Moehler M.D., Ph.D.   +5 more
openaire   +3 more sources

Molecular Epidemiology of HIV-1 in Ghana: Subtype Distribution, Drug Resistance and Coreceptor Usage

Viruses, 2022
The greatest HIV-1 genetic diversity is found in West/Central Africa due to the pandemic’s origins in this region, but this diversity remains understudied.
Anna Appah, Charlotte J. Beelen, Don Kirkby, Winnie Dong, Aniqa Shahid, Brian Foley, Miriam Mensah, Vincent Ganu, Peter Puplampu, Linda E. Amoah, Nicholas I. Nii-Trebi, Chanson J. Brumme, Zabrina L. Brumme   +12 more
doaj   +1 more source

Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs [PDF]

JNCI Journal of the National Cancer Institute, 2004
Resistance to antitumor agents is a major cause of treatment failure in patients with cancer. Some mechanisms of tumor resistance to cytotoxic drugs may involve increased acidification of extracellular compartments. We investigated whether proton pump inhibitors (PPIs), currently used in the anti-acid treatment of peptic disease, could inhibit the ...
Francesca, Luciani, Massimo, Spada, Angelo, De Milito, Agnese, Molinari, Licia, Rivoltini, Annalisa, Montinaro, Manuela, Marra, Luana, Lugini, Mariantonia, Logozzi, Francesco, Lozupone, Cristina, Federici, Elisabetta, Iessi, Giorgio, Parmiani, Giuseppe, Arancia, Filippo, Belardelli, Stefano, Fais   +15 more
openaire   +2 more sources

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries [PDF]

Journal of Antimicrobial Chemotherapy, 2018
ART in the developing world has moved to a new era with the WHO recommendation to test and immediately treat HIV-positive individuals. A high frequency of pretreatment HIV drug resistance (PDR) can compromise ART efficacy. Our study presents updated estimates of PDR in seven countries from West Africa (Burkina Faso, Cameroon, Côte d'Ivoire, Mali and ...
Nicole Ngo-Giang-Huong, Thu H K Huynh, Anoumou Y Dagnra, Thomas-d’Aquin Toni, Almoustapha I Maiga, Dramane Kania, Sabrina Eymard-Duvernay, Martine Peeters, Cathia Soulie, Gilles Peytavin, Claire Rekacewicz, Marie-Laure Chaix, Avelin F Aghokeng, Avelin F Aghokeng, Ahidjo Ayouba, Françoise Brun-Vézinet, Marie-Laure Chaix, Vincent Calvez, Anoumou Dagnra, Diane Descamps, Kania Dramane, Isabelle Fournier, Almoustapha Maiga, Laure-Amélie de Monteynard, Janin Nouhin, Coumba Touré Kane, Truong Xuan Lien, Nicole Ngo-Giang-Huong, Martine Peeters, Jean-Christophe Plantier, Richard Njouom, Edouard Tuaillon, Claire Rekacewicz, Toni Thomas d’Aquin, Armel Poda, Jacques Zougrana, Saidou Ouedraogo, Macaire Ouedraogo, Armando Djiyou Djeuda, Charles Kouanfack, Nadia Mandeng, Eitel Mpoudi-Ngole, Eugene Messou, Dechi Jean Jacques, Jean François Nguessan, Oumar Dolo, Zoumana Diarra, Mamadou Cisse, Akouda Patassi, Mounérou Salou, Komla Ali-Edjé, Chureeratana Bowonwatanuwong, Suchart Thongpaen, Virat Klinbuayaem, Laddawan Laomanit, Que Anh Luong, Ton Tran   +56 more
openaire   +4 more sources

Pretreatment HIV drug resistance spread within transmission clusters in Mexico City [PDF]

Journal of Antimicrobial Chemotherapy, 2019
Abstract Background Pretreatment HIV drug resistance (HIVDR) to NNRTIs has consistently increased in Mexico City during the last decade. Objectives To infer the HIV genetic transmission network in Mexico City to describe the dynamics ...
Matías-Florentino, Margarita, Chaillon, Antoine, Ávila-Ríos, Santiago, Mehta, Sanjay R, Paz-Juárez, Héctor E, Becerril-Rodríguez, Manuel A, del Arenal-Sánchez, Silvia J, Piñeirúa-Menéndez, Alicia, Ruiz, Verónica, Iracheta-Hernández, Patricia, Macías-González, Israel, Tena-Sánchez, Jehovani, Badial-Hernández, Florentino, González-Rodríguez, Andrea, Reyes-Terán, Gustavo   +14 more
openaire   +5 more sources

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon, Lopez-Ribot, J.L., Rajendran Ranjith, Ramage, G., Leah E. Cowen, Uppuluri Priya, Robbins, N., Priya Uppuluri, Rajendran, R., Andes, D., Jose L Lopez-Ribot, David Andes, Leah E Cowen, Nicole Robbins, Uppuluri, P., Robbins Nicole, Nett Jeniel, Lopez-Ribot Jose L., Jose L. Lopez-Ribot, Cowen, L.E., Nett, J., Ranjith Rajendran, Gordon Ramage, Jeniel Nett, Andes David, Cowen Leah E.   +25 more
core   +2 more sources

Pretreatment HIV drug resistance results in virological failure and accumulation of additional resistance mutations in Ugandan children [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Pretreatment HIV drug resistance (PDR) can impair virological response to ART, jeopardizing effective treatment for children.Children aged ≤12 years initiated first-line ART in Uganda during 2010-11. Baseline and 6 monthly viral load (VL) and genotypic resistance testing if VL >1000 copies/mL was done.
Kityo, Cissy, Boerma, Ragna S., Sigaloff, Kim C. E., Kaudha, Elizabeth, Calis, Job C. J., Musiime, Victor, Balinda, Sheila, Nakanjako, Rita, Boender, T. Sonia, Mugyenyi, Peter N., Rinke de Wit, Tobias F.   +10 more
openaire   +5 more sources

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Naomi Walsh, Martin Clynes, Rizwan Sheikh, Sheikh, Rizwan, O'Connor, Robert A., Robert O’Connor, Ray McDermott, O'Connor, Robert, Clynes, Martin, Walsh, Naomi, McDermott, Ray   +10 more
core   +1 more source