Results 91 to 100 of about 49,072 (180)

Convergent generation of atypical prions in knockin mouse models of genetic prion disease

The Journal of Clinical Investigation
Most cases of human prion disease arise due to spontaneous misfolding of WT or mutant prion protein, yet recapitulating this event in animal models has proven challenging. It remains unclear whether spontaneous prion generation can occur within the mouse
Surabhi Mehra, Matthew E.C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Hamza Arshad, Jennifer K. Griffin, Kathy L. Frost, Daniel J. Walsh, Surachai Supattapone, Stephanie A. Booth, Walker S. Jackson, Joel C. Watts   +11 more
doaj   +1 more source

Long‐term stability of horizontal bone augmentation at implant sites

Periodontology 2000, EarlyView.
Abstract Horizontal bone augmentation is a fundamental surgical procedure in regenerative implant dentistry. In recent decades, this procedure has evolved, enabling clinicians to achieve predictable and stable horizontal bone augmentation that supports dental implant restorations.
Jia‐Hui Fu, Hui Jia Sophia Choo, Ding‐Sen Ong, Henry Kwek   +3 more
wiley   +1 more source

Science Attitudes: Enjoyment of Science Lessons and Interest in Pursuing a Scientific Career. High School Students' Gender Differences

School Science and Mathematics, EarlyView.
ABSTRACT In this study, the dimensions of enjoying science lessons and pursuing science careers were examined under gender considerations. Ex post facto research was conducted on high school students (N = 599) from the Canary Islands who completed a Spanish version of the Test of Science Related Attitudes (TORSA).
Luis Miguel Rivera‐Gavidia, Juan José Marrero‐Galván   +1 more
wiley   +1 more source

Inhibition and Formation of Amyloid Fibrils in the Bulk and at the Interface of Biomolecular Condensates

Angewandte Chemie, Volume 138, Issue 33, 10 August 2026.
In this review, we discuss how biomolecular condensates can inhibit amyloid aggregation in their interior, while still facilitating fibril formation at the interface between the dense and dilute phases, where molecular and mesoscale properties are likely optimal to promote protein aggregation.
Marcell Papp, Chiara Morelli, Sarah Khawaja, Paolo Arosio   +3 more
wiley   +2 more sources

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Cell adhesion molecule CD44 is dispensable for reactive astrocyte activation during prion disease

Scientific Reports
Prion diseases are fatal, infectious, neurodegenerative disorders resulting from accumulation of misfolded cellular prion protein in the brain. Early pathological changes during CNS prion disease also include reactive astrocyte activation with increased ...
Barry M. Bradford, Lauryn Walmsley-Rowe, Joe Reynolds, Nicholas Verity, Neil A. Mabbott   +4 more
doaj   +1 more source

Endoscopic Thrombin Injection for Gastric Variceal Bleeding: A Systematic Review and Meta‐Analysis of Observational and Trial Data

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objective The safety of endoscopic thrombin injection (ETI) for treating the bleeding of gastric varix (GV) in patients with portal hypertension requires further evaluation. This meta‐analysis systematically reviews the available evidence on the efficacy and safety of ETI for GV bleeding.
Wen Xu, Da‐qin Zhan, Ruo‐lan Wang, Shu Jin, Hui‐guo Ding   +4 more
wiley   +1 more source

Prion propagation in vitro: are we there yet?

International Journal of Medical Sciences, 2008
Prion diseases are caused by proteinaceous pathogens termed prions. Although the details of the mechanism of prion propagation are not fully understood, conformational conversion of cellular prion protein (PrPC) to misfolded, disease-associated scrapie ...
Chongsuk Ryou, Charles E. Mays
doaj  

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Glia, Volume 74, Issue 10, October 2026.
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann   +13 more
wiley   +1 more source

The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope

Natural Sciences, Volume 6, Issue 4, October 2026.
ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley   +1 more source