Results 101 to 110 of about 49,072 (180)

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

EUS‐Guided Gallbladder Drainage for Acute Cholecystitis in the Western World: Heterogeneity in Current Practice and the Relation With Patient Outcome

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Laparoscopic cholecystectomy is the standard treatment for acute cholecystitis (AC), but some patients are unfit for (immediate) surgery. Endoscopic ultrasound‐guided gallbladder drainage (EUS‐GBD) using a lumen‐apposing metal stent (LAMS) is increasingly used in this population.
Louis De Wispelaere, Eva Hufkens, Hannah van Malenstein, Wim Laleman, Michiel Bronswijk, Schalk van der Merwe, Roberto Di Mitri, Michele Amata, Daniela Scimeca, Niels G. Venneman, Koen R. Beukema, Alberto Larghi, Antonio Pelegrino, Felice Molinario, Dominiek De Wulf, Elise Devolder, Dennis Yang, Mustafa Arain, Natalie Cosgrove, Muhammad K. Hasan, Maham Hayat, Kambiz Kadkhodayan, Christophe Snauwaert, Roberto Trasolini, Cynthuja Thilakanathan, Shirley Jiang, Douglas G. Adler, Lionel S. D'Souza, Rogier P. Voermans, Anouk G. Overdevest, Roy L. J. Van Wanrooij, Enrique Pérez‐Cuadrado‐Robles, Willem J. Lammers, Pieter Jan de Jonge, Marco J. Bruno, Helena Degroote, Thomas Billiet, Alexander Arlt, Sebastian Stefanovic, Emine Gökce, Ellen Deschepper, Pieter Hindryckx   +41 more
wiley   +1 more source

Strain-specific propagation of variant Creutzfeldt-Jakob disease prions in humanized neural cells. [PDF]

Proc Natl Acad Sci U S A
Rayner MLD, Arora P, Linehan JM, Ros H, Nihat A, Argentina F, Preston C, Schmidt C, Ribes JM, Klöhn PC, Mead S, Brandner S, Collinge J, Jat PS.   +13 more
europepmc   +1 more source

Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease. [PDF]

Sci Adv
Hannaoui S, Pritzkow S, Jürgens-Wemheuer WM, Motzkus D, Wälzlein JH, Schwenke KA, Cheng YC, Ahmed Hassan H, Zemlyankina I, Drever K, Beekes M, Schulz-Schaeffer WJ, Stahl-Hennig C, Gilch S, Soto C, Czub S, Schätzl HM.   +16 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, Volume 16, Issue 8, Page 1563-1592, August 2026.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, Volume 38, Issue 46, 18 August 2026.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties. [PDF]

PLoS Pathog
DeFranco JP, Atkinson ZN, Crowell J, Shi X, Kim S, Sun JL, Kane SJ, Telling GC.   +7 more
europepmc   +1 more source

Developing a Functional Polyelectrolyte Hybrid Layer Scaffold Coating and Evaluation of Its Performance for Interaction With Neural Cells

Advanced Materials Interfaces, Volume 13, Issue 15, 4 August 2026.
Polyelectrolyte scaffold coatings modified with Cu and Fe3O4 nanoparticles regulate neural stem cell behavior in vitro. Increased Fe3O4 content enhances mitochondrial activity and neuronal differentiation, whereas higher Cu levels reduce cell viability.
Anna Grzeczkowicz, Agata Lipko, Angelika Kwiatkowska, Marcin Strawski, Monika Drabik, Ludomira H. Granicka   +5 more
wiley   +1 more source

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability. [PDF]

J Biol Chem
Bhamra SK, Arora P, Liew M, Hosszu LLP, Batchelor M, Clarke AR, Bieschke J, Collinge J, Jat PS.   +8 more
europepmc   +1 more source

Reassessing the Proposed Creatine–PrP Axis in Endometriosis: Methodological and Mechanistic Considerations

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT The research by Chen et al. (2024) presents an innovative hypothesis linking creatine metabolism to ferroptosis resistance in endometriotic stromal cells via PrP suppression. While conceptually valuable, methodological aspects warrant reflection.
Marco Machado
wiley   +1 more source