Results 111 to 120 of about 49,072 (180)

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs. [PDF]

PLoS Pathog
Le NTT, Mercer RCC, Fang C, Sundaravadivelu A, Labadorf AT, Lin W, Kwan J, Blum B, Emili A, Harris DA.   +9 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Old nodes, new tricks: optimized methods for chronic wasting disease prion detection in preserved retropharyngeal lymph nodes. [PDF]

J Vet Diagn Invest
Munster A, Høy-Petersen J, Davis MA, Tomke SA, Niedringhaus KD, Gagne RB, Gibison M.   +6 more
europepmc   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, Volume 13, Issue 45, 13 August 2026.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

DL-3-n-Butylphthalide Protects Against PrP¹⁰⁶ ^-126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics. [PDF]

CNS Neurosci Ther
Wu W, Zhang X, Jiang M, Ma N.
europepmc   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

First report of novel single-nucleotide polymorphisms and genetic characteristics in the open reading frame of the prion protein gene (<i>PRNP</i>) in bats. [PDF]

Front Vet Sci
Tran DP, Choi DI, Na EJ, Oem JK, Jeong BH.   +4 more
europepmc   +1 more source

Reply to “Reassessing the Proposed Creatine–PrP Axis in Endometriosis: Methodological and Mechanistic Considerations”

Advanced Science, Volume 13, Issue 45, 13 August 2026.
ABSTRACT This Correspondence is a formal response to the Comment by Dr. Machado regarding our publication “Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP.” We address several conceptual concerns raised in the Comment and clarify the physiological relevance of creatine concentrations, the methodological ...
Siman Chen, Xiaoqian Ma, Yukai Liu, Zhiqi Zhong, Chunyan Wei, Mingqing Li, Xiaoyong Zhu   +6 more
wiley   +1 more source

Generation of Infectious Prions Amenable to Site-Specific Click Chemistry. [PDF]

ACS Chem Biol
Campbell RG, Iseler JN, Schwind AM, Supattapone S.   +3 more
europepmc   +1 more source

A Neuronal Cell Line Model for Studying Camel Prions. [PDF]

Pathogens
Abdulrahman B, Rahimi Aqdam S, Mosca M, Ahmed-Hassan H, Razcon-Echeagaray M, Popa L, Gilch S, Babelhadj B, Vaccari G, Schätzl HM.   +9 more
europepmc   +1 more source