Results 11 to 20 of about 14,994 (162)

Unexpected Primaquine-Induced Hemolysis in a G6PD-Normal Patient: A Case Report From Nepal. [PDF]

Clin Case Rep
ABSTRACT Primaquine, an antimalarial drug, is essential for preventing relapses of Plasmodium vivax. However, it poses a risk of hemolytic anemia, particularly in glucose‐6‐phosphate dehydrogenase (G6PD) deficient patients. This case report details a 27‐year‐old male with normal G6PD levels who developed hemolytic anemia following primaquine therapy ...
Khadka A, Subedi S, Lama N, Bhattarai I, Deuba C, Khatri U, Regmi N.   +6 more
europepmc   +2 more sources

Primaquine for Prevention of Malaria in Travelers [PDF]

Clinical Infectious Diseases, 2003
An expanding risk and range of endemic malaria threatens travelers. Primaquine is an old drug recently demonstrated to offer effective prophylaxis. Clinical trials conducted in Indonesia, Kenya, and Colombia showed that a primaquine base (30 mg per day) had protective efficacy against Plasmodium falciparum and Plasmodium vivax of 85%-93%.
Baird, J. Kevin, Fryauff, David J., Hoffman, Stephen L.   +2 more
openaire   +4 more sources

Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies. [PDF]

, 2013
BACKGROUND: Informing and evaluating malaria control efforts relies on knowledge of local transmission dynamics. Serological and molecular tools have demonstrated great sensitivity to quantify transmission intensity in low endemic settings where the ...
Baidjoe, Amrish, Bousema, Teun, Cox, Jonathan, Drakeley, Chris, Grignard, Lynn, Kariuki, Simon, Makori, Euniah, Osoti, Victor, Ploemen, Ivo, Sauerwein, Robert, Shagari, Shehu, Stevenson, Jennifer, Stone, Will, Sutherland, Colin   +13 more
core   +3 more sources

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections [PDF]

, 2013
Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox Singh, Janet, Daneshvar, Cyrus, Davis, Timothy M. E., Divis, Paul C. S., Rafa'ee, Mohammad Z., Singh, Balbir, Zakaria, Siti K.   +6 more
core   +1 more source

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]

, 2014
Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel, Campo, Brice, Chatterjee, Arnab K, Chen, Zhong, Diagana, Thierry T, Gagaring, Kerstin, Glynne, Richard J, Klooster, Els J, Kocken, Clemens HM, Kuhen, Kelli, Leroy, Didier, Luty, Adrian, McNamara, Case W, Nagle, Advait, Plouffe, David M, Remarque, Edmond J, Roland, Jason, Sauerwein, Robert, Thomas, Alan W, van Amsterdam, Sandra M, van den Berg, Alexander, van Gemert, Geert-Jan, Voorberg-van der Wel, Annemarie, Winzeler, Elizabeth A, Yeung, Bryan KS, Zeeman, Anne-Marie   +25 more
core   +1 more source

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [PDF]

, 2019
We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions.
Lind, Pedro G., Louçã, Jorge, Mendes, António M., Sequeira, João   +3 more
core   +2 more sources

Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. [PDF]

, 2004
Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement
Billington, OJ, Gillespie, SH, Gosling, RD, Ling, CL, Lipman, MC, McHugh, TD, Patel, S, Pope, CF   +7 more
core   +2 more sources

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria [PDF]

, 2009
With the availability of new preventive and curative interventions, global malaria control has been strengthened significantly in recent years. Drugs effective in reducing malaria gametocytaemia might contribute to local elimination and possible long ...
Coulibaly, Boubacar, Klose, Christina, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Zoungrana, Augustin   +7 more
core   +1 more source

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases [PDF]

, 2019
Background: Pharmaceutical compounding of orphan active ingredients can offer cost-effective treatment to patients when no other drug product is available for a rare disease or during periods of drug product shortages.
Boussery, Koen, De Spiegeleer, Bart, Peeters, E, Remon, Jean Paul, Van Tongelen, Inge, Vanhoorne, Valérie, Vervaet, Chris, Wynendaele, Evelien   +7 more
core   +2 more sources

Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination

, 2015
Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting.
Eckhoff, Philip, Gerardin, Jaline, Wenger, Edward A.   +2 more
core   +1 more source