Results 11 to 20 of about 18,376 (235)

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2014
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
N. P. Dhammika Nanayakkara, Babu L. Tekwani, H. M. T. Bandara Herath, Rajnish Sahu, Montip Gettayacamin, Anchalee Tungtaeng, Yvonne Van Gessel, Paul Baresel, Kristina S. Wickham, Marilyn S. Bartlett, Frank R. Fronczek, Victor Meléndez, Colin Ohrt, Gregory A. Reichard, James D. McChesney, Rosemary Rochford, Larry Walker   +16 more
openalex   +4 more sources

Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis [PDF]

BMJ Global Health, 2023
Background The optimal dosing of primaquine to prevent relapsing Plasmodium vivax malaria in South Asia remains unclear. We investigated the efficacy and safety of different primaquine regimens to prevent P.
Reena Verma, Robert J. Commons, Apoorv Gupta, Manju Rahi, Gupta Anant, Praveen K. Bharti, Kamala Thriemer, Megha Rajasekhar, Sauman Singh-Phulgenda, Bipin Adhikari, Mohammad Shafiul Alam, Prakash Ghimire, Wasif Ali Khan, Rishikesh Kumar, Toby Leslie, Benedikt Ley, Alejandro Llanos‐Cuentas, Sasithon Pukrittayakamee, Komal Raj Rijal, Mark Rowland, Kavitha Saravu, J. A. Simpson, Philippe J. Guérin, Ric N. Price, Amit Sharma   +24 more
openalex   +3 more sources

Batch Synthesis of Primaquine Diphosphate Anti-Malarial Drug. [PDF]

Chemistry
According to the WHO, a child under the age of five dies every 2 minutes from malaria in Africa. It is therefore paramount that access and availability of anti‐malarial drugs must be improved. We report a process for the synthesis of Primaquine Diphosphate, where key intermediates were obtained in a much shorter reaction time compared to processes ...
Akwi FM, Swartbooi S, Watts P.
europepmc   +2 more sources

Genetic Variation of G6PD and CYP2D6: Clinical Implications on the Use of Primaquine for Elimination of Plasmodium vivax

Frontiers in Pharmacology, 2021
Primaquine, an 8-aminoquinoline, is the only medication approved by the World Health Organization to treat the hypnozoite stage of Plasmodium vivax and P. ovale malaria.
Alexandra G. A. Stewart, Peter A. Zimmerman, James S. McCarthy, James S. McCarthy   +3 more
doaj   +1 more source

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

BMC Medicine, 2022
Background In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate ...
Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens, Anders Bjorkman, Joelle M. Brown, Umberto D’Alessandro, Alassane A. Dicko, Badria El-Sayed, Salah-Eldin Elzaki, Alice C. Eziefula, Bronner P. Gonçalves, Muzamil Mahdi Abdel Hamid, Akira Kaneko, Simon Kariuki, Wasif Khan, Titus K. Kwambai, Benedikt Ley, Billy E. Ngasala, Francois Nosten, Joseph Okebe, Aaron M. Samuels, Menno R. Smit, Will J. R. Stone, Inge Sutanto, Feiko Ter Kuile, Roger C. Tine, Alfred B. Tiono, Chris J. Drakeley, Roly Gosling, Andy Stergachis, Karen I. Barnes, Ingrid Chen   +44 more
doaj   +1 more source

Effects of co-treatment of Plasmodium berghei-infected mice with aqueous extract of Ocimum gratissimum leaves and primaquine on glucose-6-phosphate dehydrogenase activity, hematological, and antioxidant parameters

Journal of Ayurveda and Integrative Medicine, 2022
Background: It has been observed that most malaria patients especially G6PD-deficient patients usually experience oxidative stress and severe anemia when treated with primaquine.
Shedrach Kanu C, Chinyere Aloke, Nwabueze Elom I, Chinedum Eleazu O   +3 more
doaj   +1 more source

Primaquine

Reactions Weekly, 2006
europepmc   +3 more sources

Experimental Evidence That Blood Parasite Infection Affects Incubation Patterns in a Cavity-Nesting Songbird. [PDF]

Integr Zool
Chronic blood parasite infections in wild birds can affect their incubation behavior. In pied flycatchers, females with reduced parasite infections incubated for longer than control females. Despite behavioral changes, no immediate effects on fitness were observed.
García-Del Río M, Merino S, Chércoles-Nieto J, Baldan D, Fuertes-Recuero M, Cantarero A.   +5 more
europepmc   +2 more sources

Modelling primaquine-induced haemolysis in G6PD deficiency

eLife, 2017
Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd).
James A Watson, Walter RJ Taylor, Didier Ménard, Sim Kheng, Nicholas J. White   +4 more
openalex   +3 more sources

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine

Malaria Journal, 2020
Background Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission.
Seif Shekalaghe, Dominic Mosha, Ali Hamad, Thabit A. Mbaga, Michael Mihayo, Teun Bousema, Chris Drakeley, Salim Abdulla   +7 more
doaj   +1 more source