Results 21 to 30 of about 14,994 (162)
Barriers to prompt and effective treatment of malaria in northern Sri Lanka. [PDF]
, 2002 BACKGROUND: For the past 18 years, northern Sri Lanka has been affected by armed ethnic conflict. This has had a heavy impact on displacement of civilians, health delivery services, number of health professionals in the area and infrastructure. The north
Abeyasinghe, R +2 more
core +3 more sources
Reinventing primaquine for endemic malaria [PDF]
Expert Opinion on Emerging Drugs, 2012 After sixty years of continuous use, primaquine remains the only therapy licensed for arresting transmission and relapse of malaria. The US Army developed primaquine for soldiers in a wartime crisis setting. Dosing strategies suited to that narrow population were adopted without modification or validation for the broader population of humans exposed to
openaire +3 more sources
Reactivity of Blood Samples Spotted onto Filter Papers in the WST-8 Method for Screening of G6PD Deficiency. [PDF]
, 2006 Deficiency of glucose-6-phosphate dehydrogenase (G6PD) causes acute hemolytic anemia triggered by oxidative drugs such as primaquine. It is therefore essential in malaria-endemic areas for malaria patients to be confirmed for their G6PD activity before ...
Arai, Meiji +3 more
core +1 more source
Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. [PDF]
, 2007 BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection.
Anderson, T J C +14 more
core +2 more sources
Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children [PDF]
, 2017 Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and areas aiming for malaria elimination.
Bousema, Teun +8 more
core +2 more sources
Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes
Annals of Human Genetics, EarlyView.ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott +3 more
wiley +1 more source
Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.
, 2009 Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew +5 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani +4 more
wiley +1 more source
Review of pyronaridine anti-malarial properties and product characteristics. [PDF]
, 2012 Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J +7 more
core +2 more sources
Tropical Medicine &International Health, Volume 30, Issue 5, Page 437-457, May 2025.Abstract Accurate diagnosis of glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is crucial for relapse malaria treatment using 8‐aminoquinolines (primaquine and tafenoquine), which can trigger haemolytic anaemia in G6PD‐deficient individuals. This is particularly important in regions where the prevalence of G6PD deficiency exceeds 3%–5%, including ...
Usa Boonyuen +11 more
wiley +1 more source