Results 21 to 30 of about 16,193 (191)

Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia

Malaria Journal, 2019
Background Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited.
Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A. Lampah, Kamala Thriemer, Nicholas M. Anstey, Paulus Sugiarto, Julie A. Simpson, Ric N. Price, Nicholas M. Douglas, Jeanne R. Poespoprodjo   +11 more
doaj   +1 more source

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

Redox Biology, 2016
Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax.
Anaïs Lalève, Cindy Vallières, Marie-Pierre Golinelli-Cohen, Cécile Bouton, Zehua Song, Grzegorz Pawlik, Sarah M. Tindall, Simon V. Avery, Jérôme Clain, Brigitte Meunier   +9 more
doaj   +1 more source

Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects. [PDF]

PLoS ONE, 2016
Primaquine is the only drug consistently effective against mature gametocytes of Plasmodium falciparum. The transmission blocking dose of primaquine previously recommended was 0.75 mg/kg (adult dose 45 mg) but its deployment was limited because of ...
Germana Bancone, Nongnud Chowwiwat, Raweewan Somsakchaicharoen, Lalita Poodpanya, Paw Khu Moo, Gornpan Gornsawun, Ladda Kajeechiwa, May Myo Thwin, Santisuk Rakthinthong, Suphak Nosten, Suradet Thinraow, Slight Naw Nyo, Clare L Ling, Jacher Wiladphaingern, Naw Lily Kiricharoen, Kerryn A Moore, Nicholas J White, Francois Nosten   +17 more
doaj   +1 more source

Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure

Frontiers in Pharmacology, 2022
Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of Plasmodium vivax and P.
Jasmine M. Olvany, Jasmine M. Olvany, Jasmine M. Olvany, Scott M. Williams, Scott M. Williams, Peter A. Zimmerman, Peter A. Zimmerman   +6 more
doaj   +1 more source

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. [PDF]

, 2007
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection.
Anderson, T J C, Carlton, J, Day, N P J, Guthmann, J P, Imwong, M, Kim, J R, Looareesuwan, S, Nair, S, Nandy, A, Nosten, F, Pukrittayakamee, S, Snounou, G, Sudimack, D, Tanomsing, N, White, N J   +14 more
core   +2 more sources

High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia [PDF]

, 1998
A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV‐8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS). Prevalence of antibodies to HHV‐8 sVCA
Angeloni, Antonio, Cerimele, Decio, Cottoni, Francesca Maria Giovanna, Faggioni, Alberto, Heston, Lee, Lin, Su-Fang, Masala, Maria Vittoria, Miller, George, Rigsby, Michael, Sirianni, Maria Caterina, Sun, Ren, Uccini, Stefania   +11 more
core   +1 more source

Using G6PD tests to enable the safe treatment of Plasmodium vivax infections with primaquine on the Thailand-Myanmar border: A cost-effectiveness analysis.

PLoS Neglected Tropical Diseases, 2017
BackgroundPrimaquine is the only licensed antimalarial for the radical cure of Plasmodium vivax infections. Many countries, however, do not administer primaquine due to fear of hemolysis in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency ...
Angela Devine, Minnie Parmiter, Cindy S Chu, Germana Bancone, François Nosten, Ric N Price, Yoel Lubell, Shunmay Yeung   +7 more
doaj   +1 more source

Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

Molecules, 2021
The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated.
Waritda Pookmanee, Siriwan Thongthip, Jeeranut Tankanitlert, Mathirut Mungthin, Chonlaphat Sukasem, Supeecha Wittayalertpanya   +5 more
doaj   +1 more source

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources

Primaquine radical cure of Plasmodium vivax: a critical review of the literature

Malaria Journal, 2012
Background Primaquine has been the only widely available hypnozoitocidal anti-malarial drug for half a century. Despite this its clinical efficacy is poorly characterized resulting in a lack of consensus over the optimal regimen for the radical cure of ...
John George K, Douglas Nicholas M, von Seidlein Lorenz, Nosten Francois, Baird J, White Nicholas J, Price Ric N   +6 more
doaj   +1 more source