Results 31 to 40 of about 16,193 (191)

Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model [PDF]

, 2015
The undetectable hypnozoite reservoir for relapsing Plasmodium vivax and P. ovale malarias presents a major challenge for malaria control and elimination in endemic countries.
Bassat, Quique, Betuela, Inoni, Brewster, Jessica, Felger, Ingrid, Hofmann, Natalie E., Karl, Stephan, Kinboro, Benson, Kiniboro, Benson, Li Wai Suen, Connie S. N., Lorry, Lina, Mueller, Ivo, Robinson, Leanne J., Samol, Lornah, Schofield, Louis, Siba, Peter M., Silkey, Mariabeth, Tarongka, Nandao, Waltmann, Andreea, Wampfler, Rahel, White, Michael T.   +19 more
core   +7 more sources

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +2 more sources

Lead clinical and pre-clinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations [PDF]

, 2014
To achieve malarial elimination we must employ interventions that reduce the exposure of human populations to infectious mosquitoes. To this end, numerous anti-malarial drugs are under assessment in a variety of transmission-blocking assays which fail to
Blagborough, A.M., Brock, P.M., Churcher, T.S., Delves, M.J., Gething, P.W., Ghani, A.C., Leroy, D., Sala, K.A., Sinden, R.E., Upton, L.M.   +9 more
core   +4 more sources

Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

, 2009
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew, Gosling, Roly, Gesase, Samwel, Mosha, Jacklin, Greenwood, Brian, Chandramohan, Daniel   +5 more
core   +1 more source

Safety and Efficacy of Adding a Single Low Dose of Primaquine to the Treatment of Adult Patients With Plasmodium falciparum Malaria in Senegal, to Reduce Gametocyte Carriage: A Randomized Controlled Trial. [PDF]

, 2017
Introduction: More information is needed about the safety of low-dose primaquine in populations where G6PD deficiency is common. Methods: Adults with Plasmodium falciparum malaria were randomized to receive 1 of 3 artemisinin combination therapies (ACTs)
Fall, Fatou B, Faye, Babacar, Faye, Babacar T, Gaye, Oumar, Greenwood, Brian, Milligan, Paul, Ndiaye, Jean Louis, Ndiaye, Magatte, Poirot, Eugenie, Sow, Doudou, Sylla, Khadime, Tine, Roger C, Wang, Duolao   +12 more
core   +4 more sources

The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis [version 2; peer review: 2 approved]

Wellcome Open Research, 2019
Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group.
Cindy S. Chu, Germana Bancone, Nay Lin Soe, Verena I. Carrara, Gornpan Gornsawun, François Nosten   +5 more
doaj   +1 more source

CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region

Frontiers in Pharmacology, 2021
Genetic variability was linked with individual responses to treatment and susceptibility to malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological ...
Paula Ferreira Salles, Daiana Souza Perce-da-Silva, Atila Duque Rossi, Luisa Riehl Raposo, Aina Danaisa Ramirez Ramirez, Otílio Machado Pereira Bastos, Lilian Rose Pratt-Riccio, Gustavo Capatti Cassiano, Andrea Regina Souza Baptista, Cynthia Chester Cardoso, Dalma Maria Banic, Ricardo Luiz Dantas Machado   +11 more
doaj   +1 more source

Are transnational tobacco companies' market access strategies linked to economic development models? A case study of South Korea. [PDF]

, 2013
Transnational tobacco companies (TTCs) have used varied strategies to access previously closed markets. Using TTCs' efforts to enter the South Korean market from the late 1980s as a case study, this article asks whether there are common patterns in these
Amon, A, Asgari, M, Blake, C, Choi, A, Erben, T, Glazebrook, K, Harnois-Déraps, J, Heymans, C, Hildebrandt, H, Hoekstra, H, Johnson, A, Joudaki, S, Klaes, D, Kuijken, K, Lidman, C, Mead, A, Miller, L, Parkinson, D, Poole, GB, Schneider, P, Viola, M, Wolf, C   +21 more
core   +6 more sources

Relapse of imported Plasmodium vivax malaria is related to primaquine dose: a retrospective study

Malaria Journal, 2012
Background Relapsing Plasmodium vivax infection results in significant morbidity for the individual and is a key factor in transmission. Primaquine remains the only licensed drug for prevention of relapse.
Townell Nicola, Looke David, McDougall David, McCarthy James S   +3 more
doaj   +1 more source

G6PD Variants and Haemolytic Sensitivity to Primaquine and Other Drugs

Frontiers in Pharmacology, 2021
Restrictions on the cultivation and ingestion of fava beans were first reported as early as the fifth century BC. Not until the late 19th century were clinical descriptions of fava-induced disease reported and soon after characterised as “favism” in the ...
Germana Bancone, Germana Bancone, Cindy S. Chu, Cindy S. Chu   +3 more
doaj   +1 more source