Results 31 to 40 of about 18,376 (235)

Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison

Malaria Journal, 2018
Background The preventive treatment of Plasmodium vivax relapse recommended by the World Health Organization is primaquine at a dose of 15 mg/day for 14 days, except for malaria cases from Asia and Oceania.
Audrey Valdes, Loic Epelboin, Emilie Mosnier, Gaelle Walter, Guillaume Vesin, Philippe Abboud, Alessia Melzani, Denis Blanchet, Nicaise Blaise, Mathieu Nacher, Magalie Demar, Felix Djossou   +11 more
doaj   +1 more source

Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. [PDF]

PLoS Neglected Tropical Diseases, 2018
Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure').
Judith Recht, Elizabeth A Ashley, Nicholas J White   +2 more
doaj   +1 more source

Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening

Pathogens, 2023
Primaquine for radical cure of Plasmodium vivax malaria poses a potentially life-threatening risk of haemolysis in G6PD-deficient patients. Herein, we review five events of acute haemolytic anaemia following the administration of primaquine in four ...
Ayleen Kosasih, Robert James, Nguyen Hoang Chau, Michelle M. Karman, Lydia Visita Panggalo, Lyndes Wini, Ngo Viet Thanh, Thomas Obadia, Ari Winasti Satyagraha, Puji Budi Setia Asih, Din Syafruddin, Walter R. J. Taylor, Ivo Mueller, Inge Sutanto, Harin Karunajeewa, Ayodhia Pitaloka Pasaribu, J. Kevin Baird   +16 more
doaj   +1 more source

Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. [PDF]

, 2004
Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement
Billington, OJ, Gillespie, SH, Gosling, RD, Ling, CL, Lipman, MC, McHugh, TD, Patel, S, Pope, CF   +7 more
core   +2 more sources

Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia

Malaria Journal, 2019
Background Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited.
Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A. Lampah, Kamala Thriemer, Nicholas M. Anstey, Paulus Sugiarto, Julie A. Simpson, Ric N. Price, Nicholas M. Douglas, Jeanne R. Poespoprodjo   +11 more
doaj   +1 more source

Safety, tolerability, and efficacy of high versus low-dose, short versus long-course daily primaquine for the radical cure of uncomplicated Plasmodium vivax malaria in children under 15 years of age: an open-label, non-inferiority, randomized controlled trial (CHILDPRIM). [PDF]

Malar J
Pacheco ALO, Omena AG, Baía-da-Silva DC, Jardim TAP, Silva DCB, Lopes APB, Barbosa LRA, Souza IG, Araujo RF, Nogueira LOS, Vale SCN, Melo GC, Cordeiro JSM, Bassat Q, Sampaio VS, Lima VDS, Martinez-Espinosa FE, Mourão MPG, Monteiro WM, Alecrim MGC, Brito-Sousa JD, Lacerda MVG.   +21 more
europepmc   +2 more sources

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]

, 2014
Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel, Campo, Brice, Chatterjee, Arnab K, Chen, Zhong, Diagana, Thierry T, Gagaring, Kerstin, Glynne, Richard J, Klooster, Els J, Kocken, Clemens HM, Kuhen, Kelli, Leroy, Didier, Luty, Adrian, McNamara, Case W, Nagle, Advait, Plouffe, David M, Remarque, Edmond J, Roland, Jason, Sauerwein, Robert, Thomas, Alan W, van Amsterdam, Sandra M, van den Berg, Alexander, van Gemert, Geert-Jan, Voorberg-van der Wel, Annemarie, Winzeler, Elizabeth A, Yeung, Bryan KS, Zeeman, Anne-Marie   +25 more
core   +1 more source

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

Redox Biology, 2016
Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax.
Anaïs Lalève, Cindy Vallières, Marie-Pierre Golinelli-Cohen, Cécile Bouton, Zehua Song, Grzegorz Pawlik, Sarah M. Tindall, Simon V. Avery, Jérôme Clain, Brigitte Meunier   +9 more
doaj   +1 more source

Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects. [PDF]

PLoS ONE, 2016
Primaquine is the only drug consistently effective against mature gametocytes of Plasmodium falciparum. The transmission blocking dose of primaquine previously recommended was 0.75 mg/kg (adult dose 45 mg) but its deployment was limited because of ...
Germana Bancone, Nongnud Chowwiwat, Raweewan Somsakchaicharoen, Lalita Poodpanya, Paw Khu Moo, Gornpan Gornsawun, Ladda Kajeechiwa, May Myo Thwin, Santisuk Rakthinthong, Suphak Nosten, Suradet Thinraow, Slight Naw Nyo, Clare L Ling, Jacher Wiladphaingern, Naw Lily Kiricharoen, Kerryn A Moore, Nicholas J White, Francois Nosten   +17 more
doaj   +1 more source

Safety and efficacy of single-dose primaquine to interrupt Plasmodium falciparum malaria transmission in children compared with adults: a systematic review and individual patient data meta-analysis. [PDF]

Lancet Infect Dis
Yilma D, Stepniewska K, Bousema T, Drakeley C, Eachempati P, Guerin PJ, Mårtensson A, Mwaiswelo R, Taylor WR, Barnes KI, WWARN Paediatric Primaquine for P falciparum Transmission Blocking Study Group.   +10 more
europepmc   +2 more sources