Results 41 to 50 of about 14,994 (162)

Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model [PDF]

, 2015
The undetectable hypnozoite reservoir for relapsing Plasmodium vivax and P. ovale malarias presents a major challenge for malaria control and elimination in endemic countries.
Bassat, Quique, Betuela, Inoni, Brewster, Jessica, Felger, Ingrid, Hofmann, Natalie E., Karl, Stephan, Kinboro, Benson, Kiniboro, Benson, Li Wai Suen, Connie S. N., Lorry, Lina, Mueller, Ivo, Robinson, Leanne J., Samol, Lornah, Schofield, Louis, Siba, Peter M., Silkey, Mariabeth, Tarongka, Nandao, Waltmann, Andreea, Wampfler, Rahel, White, Michael T.   +19 more
core   +7 more sources

PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 738-750, April 2025.
ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Lisa M. Almond, Khaled Abduljalil, Amita Pansari, Beata Kusmider, Hannah M. Jones, Karen Rowland Yeo, Iain Gardner, Muhammad Faisal, Anne Claire Marrast, Myriam El Gaaloul, Jörg J. Möhrle, Nada Abla   +11 more
wiley   +1 more source

Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]

, 2018
Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core   +2 more sources

Human Infections with Plasmodium knowlesi, the Philippines. [PDF]

, 2008
Five human cases of infection with the simian malaria parasite Plasmodium knowlesi from Palawan, the Philippines, were confirmed by nested PCR. This study suggests that this zoonotic infection is found across a relatively wide area in Palawan and ...
Bell, David, Chiodini, Peter, Curameng, Peter, Espina, Ronald, Espino, Fe, Lee, Kim-Sung, Luchavez, Jennifer, Nolder, Debbie, Singh, Balbir, Sutherland, Colin   +9 more
core   +3 more sources

Host Disease Tolerance Predicts Transmission Probability for a Songbird Pathogen

Ecology and Evolution, Volume 15, Issue 3, March 2025.
The effects of host disease tolerance on pathogen transmission are not well understood. Here, we use wild‐caught house finches to show that natural variation in tissue‐specific tolerance to a bacterial pathogen affects the transmission of this pathogen.
Amberleigh E. Henschen, Francis E. Tillman, Sarah Coleman Ruston, Dana M. Hawley, James S. Adelman   +4 more
wiley   +1 more source

Unusual Radiographic Presentation of Pneumocystis Pneumonia in a Patient with AIDS. [PDF]

, 2017
Pneumocystis jirovecii pneumonia (PCP) typically presents as an interstitial and alveolar process with ground glass opacities on chest computed tomography (CT).
Block, Brian L, Cattamanchi, Adithya, Ferris, Sean P, Huang, Laurence, Mehta, Tejas, Ortiz, Gabriel M, Vu, Thienkhai H   +6 more
core   +3 more sources

Pharmacometric and statistical considerations for dose optimization

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 2, Page 279-291, February 2025.
Abstract The probability of target attainment (PTA) is a common metric in drug dose optimization, but it requires a specific known target concentration threshold. Such target thresholds are not always available for some treatments, and patient and disease groups, particularly when treating children.
Palang Chotsiri, Prasert Yodsawat, Richard M. Hoglund, Julie A. Simpson, Joel Tarning   +4 more
wiley   +1 more source

Real‐World Utilization of Medications With Pharmacogenetic Recommendations in Older Adults: A Scoping Review

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Pharmacogenetic testing provides patient genotype information which could influence medication selection and dosing for optimal patient care. Insurance coverage for pharmacogenetic testing varies widely. A better understanding of the commonly used medications with clinically important pharmacogenetic recommendations can inform which ...
Bella D. Ianni, Chin Hang Yiu, Edwin C. K. Tan, Christine Y. Lu   +3 more
wiley   +1 more source

Molecular evidence of Plasmodium vivax infection in Duffy negative symptomatic individuals from Dschang, West Cameroon [PDF]

, 2017
Background: Plasmodium vivax infection is known to be rare in West/Central Africa, the most accepted explanation being the lack of expression of erythroid Duffy antigen in the local human populations.
De Santis, Riccardo, Djeunang Dongho, Ghyslaine Bruna, Faggioni, Giovanni, Lista, Florigio Romano., Mbida, Mpoame, Paganotti, Giacomo Maria, Pomponi, Alice, Rezza, Giovanni, Russo, Gianluca, Sanou Sobze, Martin, Tebano, Gianpiero, Vullo, Vincenzo   +11 more
core   +2 more sources

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source