Results 61 to 70 of about 16,193 (191)

Barriers to prompt and effective treatment of malaria in northern Sri Lanka. [PDF]

, 2002
BACKGROUND: For the past 18 years, northern Sri Lanka has been affected by armed ethnic conflict. This has had a heavy impact on displacement of civilians, health delivery services, number of health professionals in the area and infrastructure. The north
Abeyasinghe, R, Pakianathar, M V, Reilley, B   +2 more
core   +3 more sources

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Malaria in Nonimmune Travelers [PDF]

, 1994
Background: With the current increase of international travel to tropical endemic areas, the incidence of malaria being imported into nonendemic countries has increased significantly.
Jelinek, Thomas, Löscher, Thomas, Nothdurft, H. D.   +2 more
core   +1 more source

Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations

Malaria Journal, 2009
Background Effective malaria control has successfully reduced the malaria burden in many countries, but to eliminate malaria, these countries will need to further improve their control efforts.
Hungerford Laura L, Maneeboonyang Wanchai, Thanyavanich Nipon, Yimsamran Surapon, Singhasivanon Pratap, Klein Eili Y, Lawpoolsri Saranath, Maguire James H, Smith David L   +8 more
doaj   +1 more source

Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]

, 2018
Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core   +2 more sources

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

The reality of using primaquine

Malaria Journal, 2010
Background Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to ...
Bancone Germana, Burgoine Kathy L, Nosten François   +2 more
doaj   +1 more source

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. [PDF]

, 2018
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito ...
Bousema, Teun, Bradley, John, Brown, Joelle M, Chen, Ingrid, Diarra, Kalifa, Diawara, Halimatou, Dicko, Alassane, Drakeley, Chris, Gosling, Roly, Hwang, Jimee, Issiaka, Djibrilla, Keita, Sekouba, Kone, Daouda T, Lanke, Kjerstin, Mahamar, Almahamoudou, McCulloch, Charles, Müller, Olaf, Roh, Michelle E, Sanogo, Koualy, Soumare, Harouna M, Srinivasan, Vinay, Stone, Will JR, Traore, Sekou F   +22 more
core   +2 more sources

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 109-118, January 2026.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

Pharmacogenomic Calling From Whole‐Exome Sequencing in the Taiwanese Population—A Real‐World Experience

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Hsu‐Heng Lin, Meng‐Ju Melody Tsai, Hui‐An Chen, Rai‐Hseng Hsu, Yun‐Syuan Lin, Yi‐Lin Lin, Ching Hsu, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Ni‐Chung Lee   +9 more
wiley   +1 more source