Results 61 to 70 of about 14,994 (162)

Dr.Emb Appyter: A web platform for drug discovery using embedding vectors

Journal of Computational Chemistry, Volume 45, Issue 31, Page 2659-2665, December 5, 2024.
Dr.Emb Appyter is a user‐friendly web platform for drug discovery that uses embedding vectors to map chemical compounds and locate similar compounds closely in latent space. It efficiently identifies closely located compounds of query compounds using Faiss and provides visualizations such as 3D scatter plots, heatmaps, UpSet plots, and Drug‐Set ...
Songhyeon Kim, Hyunsu Bong, Minji Jeon
wiley   +1 more source

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. [PDF]

, 2018
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito ...
Bousema, Teun, Bradley, John, Brown, Joelle M, Chen, Ingrid, Diarra, Kalifa, Diawara, Halimatou, Dicko, Alassane, Drakeley, Chris, Gosling, Roly, Hwang, Jimee, Issiaka, Djibrilla, Keita, Sekouba, Kone, Daouda T, Lanke, Kjerstin, Mahamar, Almahamoudou, McCulloch, Charles, Müller, Olaf, Roh, Michelle E, Sanogo, Koualy, Soumare, Harouna M, Srinivasan, Vinay, Stone, Will JR, Traore, Sekou F   +22 more
core   +2 more sources

Medications and Acute Hemolysis in G6PD‐Deficient Patients – A Real‐World Study

Clinical Pharmacology &Therapeutics, Volume 116, Issue 6, Page 1537-1543, December 2024.
Many drug labels contain precautions of use in G6PD‐deficient patients due to hemolytic concerns, but much of this is based on scarce clinical, epidemiological, or structural data. In this real‐world study, we aimed to examine if the administration of presumably risky medications for G6PD‐deficient patients was followed by hemolysis. The study is based
Naomi Gronich, Bar Rosh, Nili Stein, Walid Saliba   +3 more
wiley   +1 more source

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2016
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T., Baresel, Paul, Bartlett, Marilyn S., Dhammika Nanayakkara, N. P., Fronczek, Frank R., Gettayacamin, Montip, McChesney, James D., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., Rochford, Rosemary, Sahu, Rajnish, Tekwani, Babu L., Tungtaeng, Anchalee, Van Gessel, Yvonne, Walker, Larry A., Wickham, Kristina S.   +16 more
core   +1 more source

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]

, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Atzori, C, Benfield, T, Crothers, KA, Haung, L, Helweg-Larsen, J, Miller, R, Rabodonirina, M   +6 more
core   +2 more sources

Analysis of Global Research on Malaria and Plasmodium vivax [PDF]

, 2019
Background: Malaria is one of the infectious diseases of greatest interest to the scientific community and of greatest concern to international health authorities.
Cebrián Carmona, José, Garrido Cárdenas, José Antonio, González Cerón, Lilia, Manzano Agugliaro, Francisco, Mesa Valle, Concepción   +4 more
core   +1 more source

Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial. [PDF]

, 2017
Plasmodium falciparum parasite life stages respond differently to antimalarial drugs. Sensitive stage-specific molecular assays may help to examine parasite dynamics at microscopically detectable and submicroscopic parasite densities in epidemiological ...
Bousema, Teun, Drakeley, Chris, Gonçalves, Bronner P, Lanke, Kjerstin, Nebie, Issa, Rijpma, Sanna R, Sauerwein, Robert, Schildkraut, Jodie A, Tadesse, Fitsum G, Tiono, Alfred B   +9 more
core   +2 more sources

Genetics of a Primaquin-resistant Yeast

Journal of General Microbiology, 1975
Primaquin specifically inhibits mitochondrial function in yeast. Mutants resistant to primaquin have been isolated. Genetic analysis revealed that the expression of resistance in one of them was under the control of both a nuclear gene and a cytoplasmic factor (possibly a mitochondrial gene).
openaire   +3 more sources

Shrinking the Malaria Map: A Prospectus on Malaria Elimination [PDF]

, 2009
\ud Thirty-nine countries across the world are making progress toward malaria elimination. Some are committed to nationwide elimination, while others are pursuing spatially progressive elimination within their borders.
Feachem, Richard G.A., Phillips, Allison A., Targett, Geoff rey A.   +2 more
core  

A RARE GLIMPSE AT THE EFFICACY OF PRIMAQUINE

The American Journal of Tropical Medicine and Hygiene, 2007
Primaquine, the only tool in our drug toolbox for preventing relapse of Plasmodium vivax or P. ovale malaria, may be the most enigmatic of the most commonly prescribed drugs today. Despite more than 50 years of continuous use by millions of people each year, we do not understand how it works.
openaire   +3 more sources