Results 81 to 90 of about 16,193 (191)
Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum [PDF]
, 2012 The current treatment of visceral leishmaniasis is made difficult by the low efficacy, elevated costs, low bioavailability, and high toxicity of many of the available drugs.
Ana Tomas +6 more
core +1 more source
Progression of Malaria in the Human Body, Its Effects on the Liver and Its Various Aspects
Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.Malaria, an infectious disease caused by Plasmodium parasites, is a significant global health issue, particularly in tropical and subtropical regions. Understanding the development of malaria in the human body and its effects on vital organs like the liver is crucial for effective control and prevention.
Avishek Mandal +7 more
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2009 Introducción. El tratamiento de la malaria por P. falciparum requiere de un esquema seguro, eficaz y de impacto en la transmisión. En 2006, se implementó en Antioquia el esquema artesunato-mefloquina y se adicionó primaquina para eliminar los gametocitos.
Ana María Vásquez +5 more
doaj +1 more source
International Journal of Immunogenetics, Volume 52, Issue 6, Page 371-378, December 2025.ABSTRACT Toll‐like receptors (TLRs) induce the production of pro‐inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8,
Mikaele Monik Rodrigues Inácio Silva +8 more
wiley +1 more source
Memorias do Instituto Oswaldo CruzBACKGROUND Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads.
Reem Osama A Kamel +1 more
doaj +1 more source
Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing [PDF]
, 2017 Background Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA).
Banda, Cliffor +3 more
core +3 more sources
Journal of the American Geriatrics Society, Volume 73, Issue 12, Page 3679-3689, December 2025.This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao +11 more
wiley +1 more source
Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones [PDF]
, 2008 A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P.
Jiri Gut +7 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 1152-1160, November 2025.CYP2D6 alleles with low frequency in Eurocentrically biased study populations are often excluded from pharmacogenetic investigation and consequently may have misassigned activity values. This health inequity may be contributing to imprecise dose predictions for CYP2D6‐metabolizing drugs.
Oyinlade Kehinde +6 more
wiley +1 more source