Results 211 to 220 of about 83,365 (272)

Primary chronic adrenal insufficiency of autoimmune etiology: review of the case report

, 2020
Samuel Sánchez-Sánchez, Osvaldo Rodríguez-Morales, Ernesto López-Cabrera, Yanelka Bouza-Jiménez   +3 more
openalex   +1 more source

Longitudinal trajectories of major depressive disorder provide further clinical perspectives for precision psychiatry

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Major depressive disorder (MDD) is a common and debilitating disorder. MDD was considered to be a relatively benign disorder compared to other major psychiatric disorders. However, longitudinal research revealed heterogeneous and frequently chronic course.
Murat İlhan Atagün
wiley   +1 more source

Network‐Pluralistic Psychiatry in Epilepsy: A theoretical framework and research agenda for personalized, mechanistic, and integrated care

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Psychiatric comorbidities in epilepsy are prevalent, disabling, and persistently undertreated due to conceptual and operational fragmentation between neurology and psychiatry. This paper proposes Network‐Pluralistic Psychiatry in Epilepsy (NPPE), a hypothesis‐generating, disease‐contextualized framework that integrates four mechanistic layers:
Ryouhei Ishii
wiley   +1 more source

Systematized delusions in a patient with covert hepatic encephalopathy: A clinicopathological insight into prodromal dementia with Lewy bodies

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Background Late‐onset psychosis is an early clinical manifestation of psychiatric‐onset prodromal dementia with Lewy bodies (DLB); however, its underlying neuropathology remains poorly understood. Clinicopathological correlations are often limited by the gap between symptom onset and the autopsy.
Hiroshige Fujishiro, Ito Kawakami, Kenichi Oshima, Youta Torii, Shusei Arafuka, Shuji Iritani, Kenji Ikeda   +6 more
wiley   +1 more source

Effects of Heat Exposure on Kynurenine Pathway Metabolism—Comparison Between Exertional and Exogenous Heating of the Human Body

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Background The kynurenine pathway (KP) plays a pivotal role in many diseases that involve distinct pathological mechanisms. Objectives Since KP metabolites are potential disease biomarkers, it is crucial to investigate their fluctuations under physiological conditions.
Varvara Louvrou, Nerijus Eimantas, Ema Juškevičiūtė, Rima Solianik, Marius Brazaitis, Göran Engberg, Sophie Erhardt   +6 more
wiley   +1 more source

Incidence of Autoimmune Diseases in 30,340 Danish Women With Polycystic Ovary Syndrome (PCOS) Compared to 151,520 Controls. A National Cohort Study

Clinical Endocrinology, Volume 103, Issue 6, Page 863-872, December 2025.
ABSTRACT Objective Autoimmunity can be part of the pathogenesis of polycystic ovary syndrome (PCOS), but prospective studies on autoimmune disease in population based cohorts are lacking. This study aimed to investigate incidence rates of autoimmune disease in Danish women with PCOS before and after PCOS diagnosis compared to controls.
Dorte Glintborg, Jens‐Jakob Kjer Møller, Katrine Hass Rubin, Louise Lehmann Christensen, Marianne Skovsager Andersen   +4 more
wiley   +1 more source

Significance of Exogenous Estradiol on Plasma Cortisol and Salivary Cortisol During Adrenocorticotropic Hormone Stimulation in Women With Pituitary Insufficiency

Clinical Endocrinology, Volume 103, Issue 6, Page 852-862, December 2025.
ABSTRACT Objective Oral estrogens increase the levels of cortisol binding globulin (CBG) potentially affecting test results for adrenal insufficiency. The objective was to evaluate the influence of oral and transdermal estradiol on total plasma (p) and salivary cortisol in hypogonadal women with secondary adrenal insufficiency or at risk of developing ...
Laura S. Aagaard, Jesper Krogh, Signe Perlman, Marianne Klose, Mikkel Andreassen   +4 more
wiley   +1 more source

The Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison′s Disease

Clinical Endocrinology, Volume 103, Issue 6, Page 795-804, December 2025.
ABSTRACT Objective Standard glucocorticoid (GC) replacement therapy in autoimmune Addison′s disease (AAD) fails to replicate natural cortisol rhythms. Despite adherence, patients report persistent fatigue, reduced vitality, and impaired wellbeing, ultimately lowering health‐related quality of life (HRQoL).
Sara Fletcher‐Sandersjöö, Annelies van′t Westeinde, Tim Spelman, Tatja Hirvikosi, Svetlana Lajic, Sophie Bensing   +5 more
wiley   +1 more source

Nutritional Deficiencies Following Bariatric Surgery: A Rapid Systematic Review of Case Reports of Vitamin and Micronutrient Deficiencies Presenting More Than Two Years Post‐Surgery

Clinical Obesity, Volume 15, Issue 6, December 2025.
ABSTRACT Bariatric surgery is the most clinically‐ and cost‐effective intervention for severe obesity. However, without adequate follow‐up, it can lead to nutritional deficiencies. Patients require life‐long nutritional supplements and follow‐up to prevent nutritional deficiencies from developing.
Sophie Haughton, Sarah Gentry, Helen M. Parretti   +2 more
wiley   +1 more source

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6894-6904, December 2025.
Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei, Hanzhang Wu, Ningjian Wang, Jiahao Zhu, Ranjit Mohan Anjana, Aleksandr V. Sokolov, Helgi B. Schiöth, Viswanathan Mohan, Xiao Tan   +8 more
wiley   +1 more source