Results 1 to 10 of about 12,019 (221)

Cortisol Co-Secretion and Clinical Usefulness of ACTH Stimulation Test in Primary Aldosteronism: A Systematic Review and Biases in Epidemiological Studies

Frontiers in Endocrinology, 2021
The hypothalamus-pituitary-adrenal (HPA) axis plays an important role in primary aldosteronism. Aldosterone biosynthesis is regulated not only by angiotensin II in the renin-angiotensin-aldosterone system, but also by adrenocorticotropic hormone (ACTH ...
Kosuke Inoue, Yuya Tsurutani, Tetsuo Nishikawa   +2 more
exaly   +3 more sources

Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: Aldosterone‐producing adenoma and idiopathic hyperaldosteronism

Journal of Diabetes Investigation, 2020
Aims/Introduction An increased risk of diabetes mellitus has been reported in primary aldosteronism, but the pathogenesis of glucose intolerance between the primary aldosteronism subtypes remains unclear.
Mikiko Okazaki-hada, Hitoshi Sugihara, Izumi Fukuda   +2 more
exaly   +2 more sources

Advances in the biochemical diagnostics of primary aldosteronism: from immunoassays to steroidomics and proteomics [PDF]

Frontiers in Endocrinology
Primary aldosteronism is the most common cause of secondary hypertension, yet most cases remain unrecognized and left without optimal treatment. The diagnostic inertia may be attributed to the lack of specific symptoms, insufficient awareness among ...
Alicja Szatko, Alicja Szatko, Alicja Szatko, Agata Toboła, Henrik Falhammar, Henrik Falhammar, Wojciech Zgliczyński, Piotr Glinicki, Piotr Glinicki   +8 more
doaj   +2 more sources

Is It Possible to Screen for Primary Aldosteronism Effectively in Primary Care? [PDF]

Clin Endocrinol (Oxf)
ABSTRACT Objective Primary aldosteronism (PA) is the commonest secondary cause of hypertension but case‐detection remains a challenge. Screening is usually performed in secondary care using an aldosterone:renin ratio (ARR) measurement. Here, we describe the outcomes of screening in primary care, in Oxfordshire, UK.
Dissanayake HA, Warner B, Hannon AM, Pofi R, Mihai R, James T, Shine B, Ray DW, Tomlinson JW, Pal A.   +9 more
europepmc   +2 more sources

Occurrence of Metabolic Disorders in Bilateral Primary Aldosteronism Compared to Unilateral Primary Aldosteronism [PDF]

Diseases
Background: Metabolic syndrome (MetS) is a common comorbidity associated with hypertension that occurs more often in primary aldosteronism (PA). Our work aims to investigate the prevalence of MetS and its determinants in unilateral PA and bilateral PA ...
Chiara Grasselli, Maicol Baldini, Lucia Salvi, Grazia Vestita, Maurizio Zizzo, Davide Felaco, Maria Carolina Balli, Giulia Besutti, Aurelio Negro, Angelo Ghirarduzzi   +9 more
doaj   +2 more sources

Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism [PDF]

Endocrine Journal
Pheochromocytoma is a rare form of adrenal hypertension. This study aimed to investigate the clinical characteristics and associated genetic mutations in patients with pheochromocytoma and primary aldosteronism.
Xurong Mai, Mitsuhiro Kometani, Toshiaki Kato, Ko Aiga, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Koshiro Nishimoto, Kazuyoshi Hosomichi, Atsushi Watanabe, Yuko Noda, Yoshiyu Takeda, Takashi Yoneda   +12 more
doaj   +2 more sources

The Utility of Plasma Metanephrines to Optimise Adrenal Vein Sampling for Primary Aldosteronism: A Single Centre Experience. [PDF]

Clin Endocrinol (Oxf)
ABSTRACT Background Primary aldosteronism (PA) is a prevalent yet frequently underdiagnosed cause of secondary hypertension, affecting up to 10% of hypertensive individuals and contributing to increased cardiovascular risk. Accurate diagnosis is vital, as unilateral PA cases typically require surgical intervention, while bilateral disease is managed ...
Htut Z, Alsafi A, Sharma A, Foran D, Tan T, Barnes SC, Williams EL, Papadopoulou D, Dimarco A, Palazzo F, Todd J, Fikri R, Wass J, Meeran K, Wernig F.   +14 more
europepmc   +2 more sources

Clinical significance of parathyroid hormone in mineral and glucose metabolism disorders among patients with primary aldosteronism [PDF]

SAGE Open Medicine
Objective: To investigate the differences in mineral and glucose metabolic disorders among patients with primary aldosteronism, nonfunctional adrenal tumors, and controls. Methods: A retrospective analysis was conducted on clinical data from 578 patients,
Zhilian Sun, Wenxiu Liu
doaj   +2 more sources

Mutation in Aldosterone Producing Adenoma [PDF]

Endocrinology and Metabolism, 2017
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in
Jian-Jhong Wang, Kang-Yung Peng, Vin-Cent Wu, Fen-Yu Tseng, Kwan-Dun Wu   +4 more
doaj   +1 more source

Markers of Kidney Tubular Function Deteriorate While Those of Kidney Tubule Health Improve in Primary Aldosteronism After Targeted Treatments

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Targeted treatment with mineralocorticoid receptor antagonists (MRAs) or adrenalectomy in patients with primary aldosteronism (PA) causes a decline in estimated glomerular filtration rate; however, the associated simultaneous changes in ...
Vin‐Cent Wu, Chieh‐Kai Chan, Jeff S. Chueh, Yung‐Ming Chen, Yen‐Hung Lin, Chin‐Chen Chang, Po‐Chih Lin, Shiu‐Dong Chung   +7 more
doaj   +1 more source