Results 61 to 70 of about 12,019 (221)

Blood Pressure–Lowering Effects of Aldosterone Synthase Inhibitors—A Systematic Review

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
ABSTRACT Excess aldosterone production contributes to the development of hypertension and results in fibrosis with dysfunction of the heart, vasculature and kidneys. Consequently, new agents have been developed to reduce endogenous aldosterone synthesis.
Anders Almskou Rasmussen, Ketil Lehm Nordestgaard, Ulf Simonsen, Niels Henrik Buus   +3 more
wiley   +1 more source

Clinical significance of CYP11B2 immunostaining in unilateral primary aldosteronism

Endocrine Connections
Objective: The associations between adrenal histopathology, lateralization studies, and surgical outcomes in primary aldosteronism remain poorly characterized.
Marianna Viukari, Helena Leijon, Tiina Vesterinen, Sanni Söderlund, Päivi Hämäläinen, Iina Yliaska, Päivi Rautiainen, Reeta Rintamäki, Minna Soinio, Ilkka Pörsti, Pasi I Nevalainen, Niina Matikainen   +11 more
doaj   +1 more source

Influence of antihypertensive therapy, sodium intake and the concentration of potassium in plasma on concentration of aldosterone and plasma renin activity [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2013
Introduction: Primary aldosteronism (PA) is a group of disorders which are characterized by inadequate and non-suppressible production of aldosterone. The prevalence of PA is increasing in hypertensive population.
Lalić Tijana
doaj   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Primary aldosteronism diagnosis in the intensive care unit: resistant alkalosis and hypokalemia during severe sepsis with hyperlactatemia: a case report

Journal of Medical Case Reports
Background Primary aldosteronism screening indications include hypertension (resistant, severe, early onset, with stroke/other comorbidities/sleep apnea), hypokalemia, adrenal incidentaloma, and primary aldosteronism first-degree relatives.
Yug Garg, Madhumati S. Vaishnav, Reshma Harsha, Nidhi Garg, Siddhartha Dinesha, Leena Lekkala, Thummala Kamala, Kavitha Muniraj, Sathyanarayana Srikanta, Samatvam Endocrinology Diabetes Collaborative Group   +9 more
doaj   +1 more source

Cytological Assessment of Adrenal Tumours: Insights From 22‐Years Single Centre Experience

Clinical Endocrinology, Volume 103, Issue 2, Page 157-166, August 2025.
ABSTRACT Objective The incidence of adrenal tumours has increased in the last decades, mainly due to increased use of imaging. The diagnostic evaluation of adrenal masses can be complex and, in some cases, necessitates cytological evaluation. However, concerns remain regarding the potential complications associated with adrenal gland biopsy.
Ana Carasel, Jan Calissendorff, C. Christofer Juhlin, Henrik Falhammar   +3 more
wiley   +1 more source

Adrenal computed tomography and NP-59 usefulness for diagnosing aldosterone-producing adenomas and idiopathic hyperaldosteronism in primary hyperaldosteronism

Urological Science, 2016
Objectives: Two major causes of primary aldosteronism are aldosterone-producing adenomas (APA) and idiopathic hyperaldosteronism (IHA). In this study, we attempted to determine the role of NP-59 in identifying APA prior to adrenalectomy, especially when ...
Ting-Po Lin, Allen W. Chiu, Marcelo Chen, Che-Hao Weng, Pei-Yin Ho, Jong-Ming Hsu, Wun-Rong Lin   +6 more
doaj   +1 more source

Efficacy, Quality of Life, and Cost‐Effectiveness of Superselective Adrenal Arterial Embolization in Idiopathic Hyperaldosteronism: A Comparative Study

The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
ABSTRACT Idiopathic hyperaldosteronism (IHA) is the most common subtype of primary aldosteronism, typically managed with mineralocorticoid receptor antagonists (MRAs). However, long‐term MRA therapy is associated with suboptimal cardiovascular outcomes and adverse effects.
Nouman Ali Khan, Min Mao, Rui Feng, Zhong Zuo, Muhammad Arif Asghar, Li Tao, Yongpeng Zhao, Ping Tang, Zhixing Xu, Jie Chen, Xin Li, Hong Zhao, Qiuyue Shi, Ling Wang, Yutian He, Jing Chang, Rui Xiang   +16 more
wiley   +1 more source

Rhabdomyolysis in Primary Aldosteronism: A Case Report and Review of the Literature

AACE Clinical Case Reports, 2015
: Objective: Primary aldosteronism is one of the most common causes of secondary hepertension. We present here a case of primary aldosteronism in a 38-year-old Chinese male with a 6-year history of uncontrolled hypertension that evaded diagnosis until an
Bin Yao, MD, Zhaoyi Qin, MD, PhD, Ying Tan, MD, PhD, Yi He, MD, PhD, Jinhua Yan, MD, PhD, Qiong Liang, MD, Wen Xu, MD, PhD, Jianping Weng, MD, PhD   +7 more
doaj  

Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism

Orphanet Journal of Rare Diseases, 2010
Surgically correctable forms of primary aldosteronism are characterized by unilateral aldosterone hypersecretion and renin suppression, associated with varying degrees of hypertension and hypokalemia. Unilateral aldosterone hypersecretion is caused by an
Steichen Olivier, Plouin Pierre-François, Amar Laurence   +2 more
doaj   +1 more source