Results 41 to 50 of about 95,754 (365)

Bile Acids and Biliary Fibrosis

Cells, 2023
Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
Sayed Obaidullah Aseem, Phillip B. Hylemon, Huiping Zhou   +2 more
doaj   +1 more source

Role of autoantibodies in the clinical management of primary biliary cholangitis

World Journal of Gastroenterology, 2023
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by immune-driven destruction of small intrahepatic bile ducts leading a proportion of patients to hepatic failure over the years.
E. Rigopoulou, Dimitrios-Petrou Bogdanos
semanticscholar   +1 more source

Current understanding of primary biliary cholangitis [PDF]

Clinical and Molecular Hepatology, 2021
Primary biliary cholangitis (PBC) causes chronic and persistent cholestasis in the liver, eventually resulting in cirrhosis and hepatic failure without appropriate treatment.
Atsushi Tanaka
doaj   +1 more source

Greater Transplant-free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls.

Gastroenterology, 2022
BACKGROUND AND AIMS The POISE randomized double-blind placebo-controlled trial demonstrated that obeticholic acid (OCA) reduced biomarkers associated with adverse clinical outcomes (ALP, bilirubin, AST, ALT) in patients with primary biliary cholangitis ...
C. F. Murillo Perez, H. Fisher, S. Hiu, D. Kareithi, F. Adekunle, T. Mayne, E. Malecha, E. Ness, A. J. van der Meer, W. Lammers, P. Trivedi, P. Battezzati, F. Nevens, K. Kowdley, Tony Bruns, N. Cazzagon, A. Floreani, A. Mason, A. Parés, M. Londoño, P. Invernizzi, M. Carbone, A. Lleo, M. Mayo, G. Dalekos, N. Gatselis, D. Thorburn, X. Verhelst, A. Gulamhusein, H. Janssen, Rachel Smith, Steven Flack, Victoria L. Mulcahy, M. Trauner, C. Bowlus, K. Lindor, C. Corpechot, David Jones, G. Mells, G. Hirschfield, James R. Wason, B. Hansen   +41 more
semanticscholar   +1 more source

Clinical Features and Risk Factors of Autoimmune Liver Involvement in Pediatric Inflammatory Bowel Disease [PDF]

, 2016
OBJECTIVES:Autoimmune liver disease is reported in up to 7.8% of children with inflammatory bowel disease. A distinct inflammatory bowel disease phenotype has been suggested in adults and in small pediatric cohorts.
Alexopoulou, Alvarez, Block, Boonstra, Deneau, Dotson, Faubion, Feldstein, Goyal, Gregorio, Halliday, Hirschfield, Hov, Jose, Jose, Levine, Levine, Liberal, Loftus, Loftus, Lundqvist, Maggiore, Malaty, Mieli-Vergani, Navaneethan, Noble-Jamieson, Olsson, Ordonez, Penna, Rönnblom, Sokol, Zholudev   +31 more
core   +1 more source

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury [PDF]

, 2019
Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation ...
Carpino, Guido, de Jong, Iris E M, Gaudio, Eugenio, Gouw, Annette S H, Iswandana, Raditya, Lisman, Ton, Matton, Alix P M, Olinga, Peter, Oosterhuis, Dorenda, Overi, Diletta, Porte, Robert J, Suriguga, Su, van Haaften, Wouter T, van Praagh, Jasper B, van Wijk, Louise A, Wiersema-Buist, Janneke   +15 more
core   +6 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Optimizing therapy in primary biliary cholangitis: Alkaline phosphatase at six months identifies one‐year non‐responders and predicts survival

Liver international (Print), 2023
Patients with primary biliary cholangitis (PBC) and insufficient response to ursodeoxycholic acid (UDCA), currently assessed after 1 year, are candidates for second‐line therapy.
C. F. Murillo Perez, S. Ioannou, Iman Hassanally, P. Trivedi, C. Corpechot, A. J. van der Meer, W. Lammers, P. Battezzati, K. Lindor, F. Nevens, K. Kowdley, T. Bruns, N. Cazzagon, A. Floreani, A. Mason, A. Gulamhusein, C. Ponsioen, M. Carbone, A. Lleo, M. Mayo, G. Dalekos, N. Gatselis, D. Thorburn, X. Verhelst, A. Parés, M. Londoño, H. Janssen, P. Invernizzi, R. Vuppalanchi, G. Hirschfield, B. Hansen, C. Levy   +31 more
semanticscholar   +1 more source

The incidence of portal vein thrombosis at liver transplantation [PDF]

, 1992
The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades.
Iwatsuki, S, Nonami, T, Starzl, TE, Yokoyama, I   +3 more
core   +1 more source

Risk of fractures and postfracture mortality in 3980 people with primary biliary cholangitis: A population‐based cohort study

Journal of Internal Medicine, 2023
Morbidity in primary biliary cholangitis (PBC) is multifactorial. Osteoporosis related to cholestasis is an extrahepatic complication of PBC. It is not fully established to what extent people with PBC have an increased risk for fractures, and if ...
Johanna Schönau, A. Wester, J. Schattenberg, H. Hagström   +3 more
semanticscholar   +1 more source