Results 111 to 120 of about 4,821,890 (183)
Primary Cilia in Trophoblastic Cells
HYPERTENSION, 2020 Supplemental Digital Content is available in the text. The pathogenesis of preeclampsia, a pregnancy-related disease, is not completely understood.
A. Ritter +11 more
semanticscholar +1 more source
CP110 Suppresses Primary Cilia Formation through Its Interaction with CEP290, a Protein Deficient in Human Ciliary Disease [PDF]
, 2008 SummaryPrimary cilia are nonmotile organelles implicated in signaling and sensory functions. Understanding how primary cilia assemble could shed light on the many human diseases caused by mutations in ciliary proteins.
Bossard, Carine +6 more
core +1 more source
Glia, 2020 Primary cilia are small microtubule‐based organelles capable of transducing signals from growth factor receptors embedded in the cilia membrane. Developmentally, oligodendrocyte progenitor cells (OPCs) express genes associated with primary cilia assembly,
C. L. Cullen +7 more
semanticscholar +1 more source
Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]
, 2019 The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A +9 more
core +1 more source
eLife, 2018 Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases, including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of LRRK2 ...
H. S. Dhekne +8 more
semanticscholar +1 more source
Putative roles of cilia in polycystic kidney disease [PDF]
, 2011 The last 10years has witnessed an explosion in research into roles of cilia in cystic renal disease. Cilia are membrane-enclosed finger-like projections from the cell, usually on the apical surface or facing into a lumen, duct or airway.
Jenkins, Dagan, Winyard, Paul
core +1 more source
An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue [PDF]
, 2013 BACKGROUND: Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia
Amber K O’Connor +9 more
core +1 more source
Understanding Cilia Function on POMC Neurons in Appetite and Satiety [PDF]
, 2016 poster abstractOver one-third of adults in the United States are obese. Obese individuals are at an increased risk for cardiovascular diseases, type 2 diabetes, cancer, and other health conditions, resulting in premature death.
Bansal, Ruchi +4 more
core
Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]
, 2013 The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada +10 more
core +2 more sources
Primary Cilia: Highly Sophisticated Biological Sensors
Sensors, 2009 Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells, have gained the attention of many researchers over the past decade.
Wissam A. Abou Alaiwi +2 more
doaj +1 more source