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Proximity proteomics of primary cilia in human hypothalamic neurons
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Neuronal primary cilia: a review
Cell Biology International, 2004AbstractPrimary cilia in neurons have often been regarded as rare, vestigial curiosities. However, neuronal cilia are now gaining recognition as ubiquitous organelles in the mammalian brain, raising speculation about what their functions may be. They might have some features tailored for the nervous system and others that serve needs shared by a ...
Jannon L, Fuchs, Harris D, Schwark
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Analysis of Caveolin in Primary Cilia
2020Recent evidence has indicated that caveolins are localized at the base of primary cilia, which are microtubule-based sensory organelles present on the cell surface, and that Caveolin-1 (CAV1) plays important roles in regulating ciliary membrane composition and function.
Morthorst, Stine K. +3 more
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Mechanical stimulation of primary cilia
Frontiers in Bioscience, 2008The ciliary/flagellar system is perhaps unique in biology in that not only are biochemical manipulations used to elucidate the function, but physical manipulations as well. Thus, there is a considerable need to have an integrated physical-biochemical model of a cilium and its function.
Andrew, Resnick, Ulrich, Hopfer
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Primary cilia signalling at a glance
Journal of Cell ScienceABSTRACT The primary cilium is a solitary, microtubule-based organelle present on most vertebrate cells, where it functions as a central hub for sensing and transducing extracellular signals. This Cell Science at a Glance article highlights how primary cilia integrate key signalling pathways – including Hedgehog, G protein-coupled ...
Dagmar Wachten +1 more
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Primary cilia of the corneal endothelium
American Journal of Anatomy, 1980AbstractA primary cilium is a normal component of every rabbit corneal endothelial cell, rather than being a rare or sporadic organelle, as previously believed. In common with other cilia of this type it possesses an axonemal organization of 9+0 which converts distally to 8+1; it occurs only one per cell; and the basal body is accompanied by a proximal
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Isolation of Mammalian Primary Cilia
2013Primary cilia are microtubule-based organelles found on most types of cells in the human body. Although primary cilia were long thought to be vestigial remnants of motile cilia, it is now known that primary cilia play important roles in development and physiology, and defects of primary cilia cause a wide range of human disease symptoms, termed ...
Hiroaki, Ishikawa, Wallace F, Marshall
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Role of Primary Cilia in Bone and Cartilage
Journal of Dental Research, 2021The primary cilium is a nonmotile microtubule-based organelle in most vertebrate cell types. The primary cilium plays a critical role in tissue development and homeostasis by sensing and transducing various signaling pathways. Ciliary proteins such as intraflagellar transport (IFT) proteins as well as ciliary motor proteins, kinesin and dynein ...
Z, Chinipardaz +3 more
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Primary cilia in skeletal development and disease
Experimental Cell Research, 2023Primary cilia are non-motile, microtubule-based sensory organelle present in most vertebrate cells with a fundamental role in the modulation of organismal development, morphogenesis, and repair. Here we focus on the role of primary cilia in embryonic and postnatal skeletal development.
Neha Quadri, Priyanka Upadhyai
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