Results 231 to 240 of about 37,275 (255)

Mechanobiology of Primary Cilia

2010
Within many mechanosensitive tissues and organs such as vascular endothelium, renal and liver epithelium, and bone, the cells residing within them are exposed to fluid flow. The process by which flow-induced mechanical loads are sensed by these cells and transduced into a biochemical signal is mostly unknown.
Ronald Y. Kwon, David A. Hoey, Christopher R. Jacobs   +2 more
openaire   +1 more source

Localization of primary cilia in mouse retina

Acta Histochemica, 2013
The primary cilia are considered as "cellular antennae" that sense and interchange information with the extracellular environment. Nearly all mammalian cells have a single primary cilium. In the retina, the outer segment of the photoreceptor is known to be a specialized form of primary cilium, but studies on cilia in other layers of the retina are ...
Yong-Kyu, Kim, Jin Hyoung, Kim, Young Suk, Yu, Hyuk Wan, Ko, Jeong Hun, Kim   +4 more
openaire   +2 more sources

Role of Primary Cilia in the Eye

Primary cilia are evolutionarily conserved organelles that regulate various aspects of cell development, differentiation, and function. Defects in primary cilia lead to diseases known as ciliopathies, with vision loss as one of the most frequent manifestations.
Dominik, Reichert, Ruchi, Sharma, Helen, May-Simera, Kapil, Bharti   +3 more
openaire   +2 more sources

Functional Study of the Primary Cilia in ADPKD

2016
The primary cilium is a microtubule-based organelle that is considered to be a cellular antennae, because proteins related to multiple signaling pathways such as Wnt, PDGFRα, Hh, and mechanosignaling are localized to the membrane of the primary cilium.
openaire   +2 more sources

Loss of primary cilia promotes inflammation and carcinogenesis

EMBO Reports, 2022
Carsten JANKÉ, Quentin da Costa, Rossano Lattanzio   +2 more
exaly  

Emerging principles of primary cilia dynamics in controlling tissue organization and function

EMBO Journal, 2023
Roman-Ulrich Mueller, Jay Gopalakrishnan, Anne Grapin-Botton   +2 more
exaly  

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

Cell, 2017
ELLE Robérson, Rajat Rohatgi, Mitsutoshi Setou   +2 more
exaly  

Cellular signalling by primary cilia in development, organ function and disease

Nature Reviews Nephrology, 2019
Søren Tvorup Christensen, Kirk Mykytyn, Lotte Bang Pedersen   +2 more
exaly  

Hippocampal neurons possess primary cilia in culture

Journal of Neuroscience Research, 2007
Kirk Mykytyn, Nicolas Berbari
exaly  

HDAC 2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma

EMBO Reports, 2017
Tetsuo Kobayashi
exaly