Results 41 to 50 of about 78,237 (351)
口腔疾病防治, 2020 Primary cilia are organelles present on most mammalian cells that sense environmental changes and transduce signaling, and they are the key coordinators of various signaling pathways during tissue development.
ZHOU Tao +4 more
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Primary cilia are lost in preinvasive and invasive prostate cancer. [PDF]
PLoS ONE, 2013 Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is known about the role of primary cilia in preinvasive and invasive prostate cancer.
Nadia B Hassounah +5 more
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Isolation of Primary Cilia by Shear Force [PDF]
, 2013 The cell’s primary cilium is both a mechanical and chemical sensor involved in many signaling pathways. In order to ascertain protein enrichment in the primary cilium or study sub-ciliary localization of various proteins, it is advantageous to remove the
Mitchell, Kimberly A. P.
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Evolutionary origins of sensation in metazoans: functional evidence for a new sensory organ in sponges [PDF]
, 2014 Background: One of the hallmarks of multicellular organisms is the ability of their cells to trigger responses to the environment in a coordinated manner.
Farrar, Nathan +4 more
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Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
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Tubulin glycylation controls primary cilia length [PDF]
Journal of Cell Biology, 2017 As essential components of the eukaryotic cytoskeleton, microtubules fulfill a variety of functions that can be temporally and spatially controlled by tubulin posttranslational modifications. Tubulin glycylation has so far been mostly found on motile cilia and flagella, where it is involved in the stabilization of the axoneme.
Sudarshan Gadadhar +6 more
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NDP Kinase Moves into Developing Primary Cilia [PDF]
, 2004 Inmunofluorescence staining of murine NIH3T3 fibroblasts grown at high density shows that conventional nucleoside diphosphate (NDP) kinases A and B localize to a sensory organelle, the primary cilium.
Gallagher, Betty C. +3 more
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The Roles of Primary cilia in Polycystic Kidney Disease
AIMS Molecular Science, 2013 Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders.
Sarmed H. Kathem +2 more
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Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]
, 2009 Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Abal +87 more
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Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
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