Alteration of primary cilia and intraflagellar transport 20 (IFT20) expression in oral squamous cell carcinoma (OSCC) cell lines [PDF]
PeerJBackground Aberrations in primary cilia expression and intraflagellar transport (IFT) protein function have been implicated in tumourigenesis.
Gulam Sakinah-Syed +3 more
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Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]
, 2012 Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao +2 more
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Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]
, 2020 The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J +14 more
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Frontiers in Bioengineering and Biotechnology, 2021 Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions.
Tien-Dung Do +3 more
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Primary Cilia: Putting Sensors Together [PDF]
Current Biology, 2004 Primary cilia extend like antennae from the surface of most eukaryotic cells into the environment, where they function in a variety of sensory roles. Recent studies reveal an intimate interplay between structural proteins of the centrosome and the formation of primary cilia, and provide new insight into the complex function of these fascinating ...
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PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]
, 2016 The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy +4 more
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Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury
BMC Research Notes, 2019 Objectives Primary cilia are sensory organelles which co-ordinate several developmental/repair pathways including hedgehog signalling. Studies of human renal allografts suffering acute tubular necrosis have shown that length of primary cilia borne by ...
Elizabeth Verghese +9 more
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Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion
Frontiers in Physiology, 2021 The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad range of signals, including odorants, light, mechanical stimuli, and ...
Keren I. Hilgendorf
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Autophagy and primary cilia: dual interplay [PDF]
Current Opinion in Cell Biology, 2016 Primary cilia are microtubule-based organelles for sensing of the extracellular milieu and transducing this information into the cell through a variety of molecular signaling pathways. Functioning of the primary cilium has been recently connected to autophagy, a pathway for degradation of cellular components in lysosomes. Autophagy regulates the length
Olatz, Pampliega, Ana Maria, Cuervo
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A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]
, 2017 Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla +2 more
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