Results 81 to 90 of about 4,909,079 (394)
Frontiers in Bioengineering and Biotechnology, 2021 Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions.
Tien-Dung Do +3 more
doaj +1 more source
The primary cilium influences interleukin-1 beta-induced NF kappa B signalling by regulating IKK activity [PDF]
, 2014 The primary cilium is an organelle acting as a master regulator of cellular signalling. We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and ...
A.K.T. Wann +68 more
core +1 more source
Primary cilia and forebrain development
Mechanisms of Development, 2013 With a microtubule-based axoneme supporting its plasma membrane-ensheathed projection from the basal body of almost all cell types in the human body, and present in only one copy per cell, the primary cilium can be considered an organelle sui generis.
Kerry L. Tucker +2 more
openaire +2 more sources
Mechanical behavior of primary cilia [PDF]
Cilia, 2012 We have developed a novel combined experimental/modeling approach to determine the mechanical properties of primary cilia. Specifically, we developed a large rotation formulation of cilia bending with fluid flow that accounts for rotation at the base of the cilium, the initial shape of the cilium and fluid drag at high deflection angles.
Christopher R. Jacobs +4 more
openaire +2 more sources
Specialized pro-resolving mediator Resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics [PDF]
arXiv, 2023 In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inflammation. However, cilia beating features in a CF altered environment, consisting of dehydrated airway surface liquid layer and abnormal mucus, has not been fully characterized.
arxiv
Spontaneous phase coordination and fluid pumping in model ciliary carpets [PDF]
, 2022 Ciliated tissues such as in the mammalian lungs, brains, and reproductive tracts, are specialized to pump fluid. They generate flows by the collective activity of hundreds of thousands of individual cilia that beat in a striking metachronal wave pattern.
arxiv +1 more source
Factors That Influence Primary Cilium Length [PDF]
, 2011 Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies.
Asanuma, Masato +3 more
core +1 more source
Cilia beating patterns are not hydrodynamically optimal [PDF]
Phys. Fluids 26, 091901 (2014), 2014 We examine the hydrodynamic performance of two cilia beating patterns reconstructed from experimental data. In their respective natural systems, the two beating patterns correspond to: (A) pumping-specialized cilia, and (B) swimming-specialized cilia.
arxiv +1 more source
Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts [PDF]
, 2014 Bone turnover in vivo is regulated by mechanical forces such as shear stress originating from interstitial oscillatory fluid flow (OFF), and bone cells in vitro respond to mechanical loading.
Anuphan Sittichokechaiwut +9 more
core +1 more source
Hydrodynamic flow patterns and synchronization of beating cilia [PDF]
Phys. Rev. Lett. 96, 058102 (2006), 2005 We calculate the hydrodynamic flow field generated far from a cilium which is attached to a surface and beats periodically. In the case of two beating cilia, hydrodynamic interactions can lead to synchronization of the cilia, which are nonlinear oscillators.
arxiv +1 more source