Results 71 to 80 of about 4,814,966 (373)
Lengthening primary cilia enhances cellular mechanosensitivity [PDF]
European Cells & Materials, 2017 The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
doaj +1 more source
Isolation of Primary Cilia by Shear Force [PDF]
, 2013 The cell’s primary cilium is both a mechanical and chemical sensor involved in many signaling pathways. In order to ascertain protein enrichment in the primary cilium or study sub-ciliary localization of various proteins, it is advantageous to remove the
Mitchell, Kimberly A. P.
core +2 more sources
Primary Cilium-Dependent Signaling Mechanisms [PDF]
International Journal of Molecular Sciences, 2017 Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell.
Nedaa Alomari +3 more
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Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration
Science Advances, 2020 The primary cilium regulates neuronal migration via cyclic AMP production activating protein kinase A at the centrosome. The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells.
J. Stoufflet +9 more
semanticscholar +1 more source
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar +32 more
core +1 more source
Trafficking to the primary cilium membrane
Molecular Biology of the Cell, 2017 The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of diseases affecting multiple organs, including the neural tube, kidney, and brain. The primary cilium is the site where a subset of the cell's membrane proteins is enriched. However,
Kasturi Pal +5 more
openaire +3 more sources
Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022 The chemical evolution of polyketide natural products leads to the unprecedented combination of biosynthetically related fragments in arrangements not found in Nature. The pseudo‐natural product grismonone was identified to be a potent inhibitor of Hedgehog signaling – a bioactivity that is not shared by its guiding fragments.
Michael Grigalunas +9 more
wiley +1 more source
Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Cells, 2020 Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner +4 more
semanticscholar +1 more source
The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]
, 2016 Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah +6 more
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The importance of a single primary cilium [PDF]
Organogenesis, 2013 The centrosome is the main microtubule-organizing center in animal cells, and helps to influence the morphology of the microtubule cytoskeleton in interphase and mitosis. The centrosome also templates the assembly of the primary cilium, and together they serve as a nexus of cell signaling that provide cells with diverse organization, motility, and ...
openaire +4 more sources