Results 81 to 90 of about 4,814,966 (373)
The primary cilium conducts chondrocyte mechanotransduction [PDF]
Cilia, 2012 In several cell types fluid-flow deflection of primary cilia initiates a mechanotransduction pathway via polycystin 1 and 2 (PC1/2). In articular cartilage the chondrocyte primary cilium extends into cartilage matrix. Mechanical signals including compression and fluid flow trigger mechanosensitive regulation of matrix synthesis underpinning tissue ...
CJ Haycraft +6 more
openaire +2 more sources
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]
, 2015 Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista +51 more
core +1 more source
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation [PDF]
, 2015 Funded by Marie Curie Intra European Fellowship (GENOMICDIFF) Wellcome Trust ...
Chapple, JP +4 more
core +1 more source
Cell Stress, 2019 Autophagy is a conserved molecular pathway directly involved in the degradation and recycling of intracellular components. Autophagy is associated with a response to stress situations, such as nutrients deficit, chemical toxicity, mechanical stress or ...
Naïma Zemirli +5 more
doaj +1 more source
Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer
Journal of Cellular Physiology, 2020 The primary cilium is an antennae‐like structure extent outside the cell surface. It has an important role in regulating cell‐signaling transduction to affect proliferation, differentiation and migration.
Bo Wang, Zheyong Liang, Peijun Liu
semanticscholar +1 more source
Generic flow profiles induced by a beating cilium [PDF]
Eur. Phys. J. E 35 (2012) 72, 2012 We describe a multipole expansion for the low Reynolds number fluid flows generated by a localized source embedded in a plane with a no-slip boundary condition. It contains 3 independent terms that fall quadratically with the distance and 6 terms that fall with the third power.
arxiv +1 more source
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]
, 2015 The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair +63 more
core +3 more sources
Bone Research, 2020 Human linkage studies suggest that craniofacial deformities result from either genetic mutations related to cholesterol metabolism or high-cholesterol maternal diets.
A. Suzuki +6 more
semanticscholar +1 more source
Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation
Frontiers in Cell and Developmental Biology, 2022 Primary cilia are microtubule-based, non-motile sensory organelles present in most types of growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit external signals to the cells in order to control growth, differentiation ...
Emanuela Senatore +5 more
doaj +1 more source
Excitable mechanics embodied in a walking cilium [PDF]
arXiv, 2021 Rapid transduction of sensory stimulation to action is essential for an animal to survive. To this end, most animals use the sub-second excitable and multistable dynamics of a neuromuscular system. Here, studying an animal without neurons or muscles, we report analogous excitable and multistable dynamics embedded in the physics of a 'walking' cilium ...
arxiv