Results 81 to 90 of about 18,376 (272)
Primary cilium polarity: morphogenetic consequences.
, 2018 In zebrafish inner ear, hair cell orientation in anterior and posterior maculae of the embryonic otic vesicle is different (about 30-40 degrees): this is rather unusual in planar polarity mechanism of action, instead suggests that kinocilia may be rotationally polarized.
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Robotic Materials With Bioinspired Microstructures for High Sensitivity and Fast Actuation
Advanced Science, EarlyView.In the review paper, design rationale and approaches for bioinspired sensors and actuators in robotics applications are presented. These bioinspired microstructure strategies implemented in both can improve the performance in several ways. Also, recent ideas and innovations that embed robotic materials with logic and computation with it are part of the
Sakshi Sakshi +4 more
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The role of primary cilia in neuronal function
Neurobiology of Disease, 2010 The “ciliopathies” are a newly defined group of disorders characterized by defects in the structure or function of the cellular primary cilium. Patients with these disorders display variably expressive fibrocystic renal disease, retinal blindness ...
Jeong Ho Lee, Joseph G. Gleeson
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The Primary Cilium: A Small Yet Mighty Organelle [PDF]
Journal of Investigative Dermatology, 2009 Primary cilia are small, cylindrical membrane protrusions on most vertebrate cell types. Despite an unassuming appearance, this organelle has proven to be a veritable nexus of tightly regulated cell-signal reception between the epithelium and mesenchyme. In this issue, Lehman et al.
DeRouen, Mindy C., Oro, Anthony E.
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Advanced Science, EarlyView.Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You +12 more
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Dynamics of the Primary Cilium in Shear Flow [PDF]
Biophysical Journal, 2012 In this work, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both theoretical modeling and experiment. The cilium is modeled as an elastic beam that may undergo large deflection due to the hydrodynamic load. Equilibrium results show that the anchoring effects of the basal body on the cilium axoneme behave as
Young, Y.-N., Downs, M., Jacobs, C.R.
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The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
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Scientific Reports, 2017 The morphogenic factor Sonic hedgehog (Shh) signals through the primary cilium, which relies on intraflagellar transport to maintain its structural integrity and function.
Jie Ding +7 more
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Advanced Science, EarlyView.Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li +3 more
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BMC Cell Biology, 2008 Background Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia.
Wang Weiping, Brautigan David L
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