Results 21 to 30 of about 5,426,861 (329)

Impact of Primary Immunodeficiency Diseases on the Life Experiences of Patients in Malaysia From the Caregivers’ Perspective: A Qualitative Study

Frontiers in Pediatrics, 2022
IntroductionPrimary immunodeficiency diseases (PIDs) are chronic diseases that affect the various aspects of a patient’s life. However, the impact of living with PIDs is poorly described.ObjectiveThis study aimed to explore the living experience ...
Ruwaydah Ahmed Meelad, Intan Juliana Abd Hamid, Ilie Fadzilah Hashim, Zarina Thasneem Zainudeen, Firdaus Farhani Abu Bakar, Fahisham Taib, Norsarwany Mohamad, Ernest Mangantig, Intan Hakimah Ismail, Amir Hamzah Abdul Latiff, Lokman Mohd Noh   +10 more
doaj   +1 more source

Autoimmunity in Primary Immunodeficiency Disorders: An Updated Review on Pathogenic and Clinical Implications

Journal of Clinical Medicine, 2021
During the last years, studies investigating the intriguing association between immunodeficiency and autoimmunity led to the discovery of new monogenic disorders, the improvement in the knowledge of the pathogenesis of autoimmunity, and the introduction ...
Giorgio Costagliola, S. Cappelli, R. Consolini   +2 more
semanticscholar   +1 more source

Impact of IL-15 and latency reversing agent combinations in the reactivation and NK cell-mediated suppression of the HIV reservoir

Scientific Reports, 2022
Inhibitors of histone deacetylases (HDACis) are major latency reversing agent (LRA) candidates in ‘shock and kill’ strategies to eradicate the HIV reservoir in infected patients.
Daniela Angela Covino, Maria Giovanna Desimio, Margherita Doria   +2 more
doaj   +1 more source

Reversion Mosaicism in Primary Immunodeficiency Diseases

Frontiers in Immunology, 2021
Reversion mosaicism has been reported in an increasing number of genetic disorders including primary immunodeficiency diseases. Several mechanisms can mediate somatic reversion of inherited mutations.
Hanae Miyazawa, T. Wada
semanticscholar   +1 more source

Psychosocial impact of COVID-19 pandemic on Malaysian families: a cross-sectional study

BMJ Open, 2021
Objective To investigate the psychosocial impact of COVID-19 on Malaysian families.Design A cross-sectional study performed using an anonymous online questionnaire distributed through social media, email and the Department of Social Welfare.Setting ...
Zarina Thasneem Zainudeen, Intan Juliana Abd Hamid, Muhd Nur Akmal Azizuddin, Firdaus Farhani Abu Bakar, Salina Sany, Izzal Asnira Zolkepli, Ernest Mangantig   +6 more
doaj   +1 more source

Case Report: Eosinophilic Esophagitis in a Patient With a Novel STAT1 Gain-of-Function Pathogenic Variant

Frontiers in Immunology, 2022
BackgroundSTAT1 gain-of-function (GOF) is a primary immune dysregulatory disorder marked by wide infectious predisposition (most notably chronic mucocutaneous Candidiasis), autoimmunity, vascular disease and malignant predisposition.
Ori Scott, Nigel Sharfe, Nigel Sharfe, Harjit Dadi, Harjit Dadi, Linda Vong, Linda Vong, Jenny Garkaby, Laura Abrego Fuentes, Jessica Willett Pachul, Sandra Nelles, Amit Nahum, Amit Nahum, Chaim M. Roifman, Chaim M. Roifman   +14 more
doaj   +1 more source

Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency

Journal of Clinical Immunology, 2020
Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (
S. Delavari, Hassan Abolhassani, F. Abolnezhadian, F. Babaha, S. Iranparast, H. Ahanchian, N. Moazzen, M. Nabavi, S. Arshi, M. Fallahpour, M. Bemanian, S. Shokri, Tooba Momen, M. Sadeghi-shabestari, Rasol Molatefi, A. Shirkani, Ahmad Vosughimotlagh, M. Safarirad, Meisam Sharifzadeh, S. Pashangzadeh, F. Salami, P. Shirmast, A. Rezaei, Tannaz Moeini Shad, M. Mohraz, N. Rezaei, L. Hammarström, R. Yazdani, Asghar Aghamohamamdi   +28 more
semanticscholar   +1 more source

Systematic Review of Primary Immunodeficiency Diseases in Malaysia: 1979–2020

Frontiers in Immunology, 2020
Introduction: Primary immunodeficiency diseases (PIDs) are under-reported in Malaysia. The actual disease frequency of PID in this country is unknown due to the absence of a national patient registry for PID.Objective: This systematic review aimed to ...
Intan Juliana Abd Hamid, Nur Adila Azman, Andrew R. Gennery, Ernest Mangantig, Ilie Fadzilah Hashim, Zarina Thasneem Zainudeen   +5 more
doaj   +1 more source

Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic

Frontiers in Pediatrics, 2023
BackgroundInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is clinically diverse, and children have a low risk of developing severe coronavirus disease 2019 (COVID-19). However, children with chronic diseases have a potentially
Levi Hoste, Levi Hoste, Agnieszka Prytula, Jo Dehoorne, Ruth De Bruyne, Stephanie Van Biervliet, Kathleen De Waele, Evelyn Maes, Victoria Bordon, Arnaud Vanlander, Karlien Claes, Johan Vande Walle, Petra Schelstraete, Sabine Van daele, Filomeen Haerynck, Filomeen Haerynck   +15 more
doaj   +1 more source

Primary immunodeficiency: common variable immunodeficiency [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016
By definition, primary immunodeficiencies are genetically determined diseases, which are fundamental molecular or organic defects associated with impaired immune responses, in this case there is the clinic of infectious and autoimmune diseases, with an ...
Oksana Ussenova, Dinara Gabdullina, Marina Morenko, Yelena Kovzel   +3 more
doaj   +1 more source