Results 21 to 30 of about 194,686 (217)
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie +5 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio +9 more
wiley +1 more source
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Primary Immunodeficiencies [PDF]
, 2008 Primary immunodeficiencies (PIDs), once considered to be very rare, are now increasingly recognized because of growing knowledge in the immunological field and the availability of more sophisticated diagnostic techniques and therapeutic modalities [161].
openaire +1 more source
Primary immunodeficiency: common variable immunodeficiency [PDF]
Journal of Clinical Medicine of Kazakhstan, 2016 By definition, primary immunodeficiencies are genetically determined diseases, which are fundamental molecular or organic defects associated with impaired immune responses, in this case there is the clinic of infectious and autoimmune diseases, with an increased risk of developing malignancies.
Marina Morenko +3 more
openaire +2 more sources