Results 21 to 30 of about 5,295,791 (325)

Isolated Nocardiosis, an Unrecognized Primary Immunodeficiency?

Frontiers in Immunology, 2020
Nocardiosis is an infectious disease caused by the gram-positive bacterium Nocardia spp. Although it is commonly accepted that exposure to Nocardia is almost universal, only a small fraction of exposed individuals develop the disease, while the vast ...
Ruben Martinez-Barricarte
semanticscholar   +1 more source

Systematic Review of Primary Immunodeficiency Diseases in Malaysia: 1979–2020

Frontiers in Immunology, 2020
Introduction: Primary immunodeficiency diseases (PIDs) are under-reported in Malaysia. The actual disease frequency of PID in this country is unknown due to the absence of a national patient registry for PID.Objective: This systematic review aimed to ...
Intan Juliana Abd Hamid, Nur Adila Azman, Andrew R. Gennery, Ernest Mangantig, Ilie Fadzilah Hashim, Zarina Thasneem Zainudeen   +5 more
doaj   +1 more source

Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic

Frontiers in Pediatrics, 2023
BackgroundInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is clinically diverse, and children have a low risk of developing severe coronavirus disease 2019 (COVID-19). However, children with chronic diseases have a potentially
Levi Hoste, Levi Hoste, Agnieszka Prytula, Jo Dehoorne, Ruth De Bruyne, Stephanie Van Biervliet, Kathleen De Waele, Evelyn Maes, Victoria Bordon, Arnaud Vanlander, Karlien Claes, Johan Vande Walle, Petra Schelstraete, Sabine Van daele, Filomeen Haerynck, Filomeen Haerynck   +15 more
doaj   +1 more source

Global systematic review of primary immunodeficiency registries

Expert Review of Clinical Immunology, 2020
Introduction During the last 4 decades, registration of patients with primary immunodeficiencies (PID) has played an essential role in different aspects of these diseases worldwide including epidemiological indexes, policymaking, quality controls of care/
Hassan Abolhassani, G. Azizi, L. Sharifi, R. Yazdani, M. Mohsenzadegan, S. Delavari, M. Sohani, P. Shirmast, Z. Chavoshzadeh, S. Mahdaviani, A. Kalantari, M. Tavakol, F. Jabbari-Azad, H. Ahanchian, Tooba Momen, R. Sherkat, M. Sadeghi-shabestari, S. Aleyasin, H. Esmaeilzadeh, W. Al-Herz, A. Bousfiha, A. Condino-Neto, M. Seppänen, K. Sullivan, L. Hammarström, V. Modell, F. Modell, J. Quinn, J. Orange, A. Aghamohammadi   +29 more
semanticscholar   +1 more source

Evaluation of Humoral and Cellular Responses in SARS-CoV-2 mRNA Vaccinated Immunocompromised Patients

Frontiers in Immunology, 2022
BackgroundImmunocompromised patients are at increased risk of severe COVID-19 and impaired vaccine response. In this observational prospective study, we evaluated immunogenicity of the BNT162b2 mRNA vaccine in cohorts of primary or secondary ...
Matthijs Oyaert, Marie-Angélique De Scheerder, Sophie Van Herrewege, Guy Laureys, Sofie Van Assche, Melissa Cambron, Leslie Naesens, Leslie Naesens, Levi Hoste, Levi Hoste, Karlien Claes, Karlien Claes, Filomeen Haerynck, Filomeen Haerynck, Tessa Kerre, Steven Van Laecke, Wim Van Biesen, Peggy Jacques, Bruno Verhasselt, Elizaveta Padalko   +19 more
doaj   +1 more source

Update in Primary Immunodeficiencies.

Acta bio-medica : Atenei Parmensis, 2020
Primary immunodeficiencies (PIDs) are inherited disorders classically characterized by increased susceptibility to infections. Nevertheless, in the last two decades, genomic analysis (such as NGS) coupled with biochemical and cellular studies led to a more accurate definition for a growing number of novel genetic disorders associated with PIDs.
Leonardi L., Rivalta B., Cancrini C., Chiappini E., Cravidi C., Caffarelli C., Manti S., Calvani M., Martelli A., Del Giudice M. M., Duse M., Marseglia G. L., Cardinale F.   +12 more
openaire   +3 more sources

Recent advances in primary immunodeficiency: from molecular diagnosis to treatment

F1000Research, 2020
The technological advances in diagnostics and therapy of primary immunodeficiency are progressing at a fast pace. This review examines recent developments in the field of inborn errors of immunity, from their definition to their treatment.
G. Bucciol, I. Meyts
semanticscholar   +1 more source

A Quantitative Analysis of Dynamic Mechanisms Regulating HIV Latency and Activation [PDF]

Prog. Biochem. Biophys. 2023,50(2):385-396, 2022
Objective: The reservoir of human immunodeficiency virus (HIV) latently infected cells is the major obstacle for eradication of acquired immunodeficiency syndrome (AIDS). Due to the noisy environment and multiple influencing factors in the organism, current dynamical models cannot reach a common understanding of the molecular mechanism of HIV latency ...
arxiv   +1 more source

Homozygous duplication identified by whole genome sequencing causes LRBA deficiency

npj Genomic Medicine, 2021
In more than one-third of primary immunodeficiency (PID) patients, extensive genetic analysis including whole-exome sequencing (WES) fails to identify the genetic defect.
Daniele Merico, Yehonatan Pasternak, Mehdi Zarrei, Edward J. Higginbotham, Bhooma Thiruvahindrapuram, Ori Scott, Jessica Willett-Pachul, Eyal Grunebaum, Julia Upton, Adelle Atkinson, Vy H. D. Kim, Elbay Aliyev, Khalid Fakhro, Stephen W. Scherer, Chaim M. Roifman   +14 more
doaj   +1 more source

Implementation of Early Next-Generation Sequencing for Inborn Errors of Immunity: A Prospective Observational Cohort Study of Diagnostic Yield and Clinical Implications in Dutch Genome Diagnostic Centers [PDF]

, 2021
Objective: Inborn errors of immunity (IEI) are a heterogeneous group of disorders, affecting different components of the immune system. Over 450 IEI related genes have been identified, with new genes continually being recognized.
the Genetics First for Primary Immunodeficiency Disorders Consortium
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