Results 31 to 40 of about 298,517 (337)
Selective IgM Deficiency—An Underestimated Primary Immunodeficiency
Frontiers in Immunology, 2017 Although selective IgM deficiency (SIGMD) was described almost five decades ago, it was largely ignored as a primary immunodeficiency. SIGMD is defined as serum IgM levels below two SD of mean with normal serum IgG and IgA.
Sudhir Gupta, Ankmalika Gupta
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Frontiers in Immunology, 2022 IntroductionSARS-CoV-2 vaccines’ effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune response to SARS-CoV-2 vaccines and the predictors of poor response in patients with
Arnau Antolí +43 more
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Minor Clinical Impact of COVID-19 Pandemic on Patients With Primary Immunodeficiency in Israel
Frontiers in Immunology, 2021 In the last few months the world has witnessed a global pandemic due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19).
Nufar Marcus +55 more
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A Bayesian framework for estimating vaccine efficacy per infectious contact [PDF]
Annals of Applied Statistics 2008, Vol. 2, No. 4, 1409-1431, 2009 In vaccine studies for infectious diseases such as human immunodeficiency virus (HIV), the frequency and type of contacts between study participants and infectious sources are among the most informative risk factors, but are often not adequately adjusted for in standard analyses. Such adjustment can improve the assessment of vaccine efficacy as well as
arxiv +1 more source
A Computational Pipeline for the Diagnosis of CVID Patients
Frontiers in Immunology, 2019 Common variable immunodeficiency (CVID) is one of the most frequently diagnosed primary antibody deficiencies (PADs), a group of disorders characterized by a decrease in one or more immunoglobulin (sub)classes and/or impaired antibody responses caused by
Annelies Emmaneel +13 more
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A Comprehensive Analysis of HIV Treatment Efficacy in the ACTG 175 Trial Through Multiple-Endpoint Approaches [PDF]
arXiv, 2023 In the realm of medical research, the intricate interplay of epidemiological risk, genomic activity, adverse events, and clinical response necessitates a nuanced consideration of multiple variables. Clinical trials, designed to meticulously assess the efficacy and safety of interventions, routinely incorporate a diverse array of endpoints.
arxiv
Primary Immunodeficiencies [PDF]
Mayo Clinic Proceedings, 1998 The primary immunodeficiencies are congenital disorders that affect the function of the immune system. The result is an inadequate immune response to microorganisms, self-antigens, and tumor cells, which leads to increased susceptibility to infections, autoimmunity, or malignant disease.
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Frontiers in Pediatrics, 2022 BackgroundPatients with T cell deficiency <10% of normal proliferation are indicated to receive immune reconstruction by hematopoietic stem cell transplantation (HSCT).
Hsin-Ju Lee +13 more
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Multiobjective optimization to a TB-HIV/AIDS coinfection optimal control problem [PDF]
Comput. Appl. Math. 37 (2018), no. 2, 2112--2128, 2017 We consider a recent coinfection model for Tuberculosis (TB), Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) proposed in [Discrete Contin. Dyn. Syst. 35 (2015), no. 9, 4639--4663]. We introduce and analyze a multiobjective formulation of an optimal control problem, where the two conflicting objectives are ...
arxiv +1 more source
SAGE Open Medicine, 2020 Objectives: A pair of female Malay monozygotic twins who presented with recurrent upper respiratory tract infections, hepatosplenomegaly, bronchiectasis and bicytopenia were recruited in this study.
Adiratna Mat Ripen +6 more
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