Results 31 to 40 of about 5,426,861 (329)
Isolated Nocardiosis, an Unrecognized Primary Immunodeficiency?
Frontiers in Immunology, 2020 Nocardiosis is an infectious disease caused by the gram-positive bacterium Nocardia spp. Although it is commonly accepted that exposure to Nocardia is almost universal, only a small fraction of exposed individuals develop the disease, while the vast ...
Ruben Martinez-Barricarte
semanticscholar +1 more source
Global systematic review of primary immunodeficiency registries
Expert Review of Clinical Immunology, 2020 Introduction During the last 4 decades, registration of patients with primary immunodeficiencies (PID) has played an essential role in different aspects of these diseases worldwide including epidemiological indexes, policymaking, quality controls of care/
Hassan Abolhassani +29 more
semanticscholar +1 more source
Primary Immunodeficiencies [PDF]
Mayo Clinic Proceedings, 1998 The primary immunodeficiencies are congenital disorders that affect the function of the immune system. The result is an inadequate immune response to microorganisms, self-antigens, and tumor cells, which leads to increased susceptibility to infections, autoimmunity, or malignant disease.
openaire +3 more sources
Homozygous duplication identified by whole genome sequencing causes LRBA deficiency
npj Genomic Medicine, 2021 In more than one-third of primary immunodeficiency (PID) patients, extensive genetic analysis including whole-exome sequencing (WES) fails to identify the genetic defect.
Daniele Merico +14 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundImmunocompromised patients are at increased risk of severe COVID-19 and impaired vaccine response. In this observational prospective study, we evaluated immunogenicity of the BNT162b2 mRNA vaccine in cohorts of primary or secondary ...
Matthijs Oyaert +19 more
doaj +1 more source
Immunity & Ageing, 2018 Background Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged ...
Sudhir Gupta +3 more
doaj +1 more source
Recent advances in primary immunodeficiency: from molecular diagnosis to treatment
F1000Research, 2020 The technological advances in diagnostics and therapy of primary immunodeficiency are progressing at a fast pace. This review examines recent developments in the field of inborn errors of immunity, from their definition to their treatment.
G. Bucciol, I. Meyts
semanticscholar +1 more source
Case Report: Association between cyclic neutropenia and SRP54 deficiency
Frontiers in Immunology, 2022 Autosomal dominant mutations in the signal recognition particle (SRP) 54 gene were recently described in patients with severe congenital neutropenia (SCN).
Melinda Erdős +4 more
doaj +1 more source
Frontiers in Immunology, 2019 Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining ...
C. Klemann +25 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 IntroductionSARS-CoV-2 vaccines’ effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune response to SARS-CoV-2 vaccines and the predictors of poor response in patients with
Arnau Antolí +43 more
doaj +1 more source