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Treatment of primary immunodeficiency with allogeneic transplant and gene therapy.
The treatment of primary immunodeficiency disorders with allogeneic hematopoietic cell transplantation (HCT) has a history dating back to 1968 with the first successful transplant for a patient with severe combined immunodeficiency (SCID).
S. Pai
semanticscholar +1 more source
Arthritis and X-linked agammaglobulinemia [PDF]
Primary immunodeficiencies are defined as genetically determined functional and/or quantitative abnormalities in one or more of the components of the immune system.
Chieira, C+5 more
core
Background: Intestinal parasitic infection in immunodeficient patients especially those with impaired cellular immunity, like neoplasia, renal or heart transplant needs careful consideration.
A. Esteghamati+4 more
semanticscholar +1 more source
Late onset combined immunodeficiency (LOCID) is a rare variant of common variable immunodeficiency (CVID), typically affecting adult patients who present with opportunistic infections (OI) and/or low CD4+ T lymphocytes.
Georgina Sauqué Pintos+6 more
doaj +1 more source
Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations [PDF]
: Very early onset inflammatory bowel disease (VEO-IBD) is a clinical term referring to IBD-like symptomatology arising in children younger than 6 years. VEO-IBD may be due to polygenic etiology in "pure" IBD (Crohn disease-CD and ulcerative colitis-UC),
Alaggio, Rita+15 more
core +1 more source
Conditioning Regimens for Hematopoietic Cell Transplantation in Primary Immunodeficiency
Hematopoietic cell transplantation (HCT) is an established curative treatment for children with primary immunodeficiencies. This article reviews the latest developments in conditioning regimens for primary immunodeficiency (PID).
S. Lum+5 more
semanticscholar +1 more source
Primary immunodeficiency in Hong Kong and the use of genetic analysis for diagnosis [PDF]
Objectives. To review the management of primary immunodeficiency and discuss recent advances in genetic analysis. Design. Retrospective study. Setting. University teaching hospital, Hong Kong. Patients.
Chan, KW+4 more
core
Clinical Aspects of Feline Retroviruses: A Review [PDF]
Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease.
Ackley+100 more
core +3 more sources
In silico model of infection of a CD4(+) T-cell by a human immunodeficiency type 1 virus, and a mini-review on its molecular pathophysiology [PDF]
Introduction. Can the infection due to the human immunodeficiency virus type 1 induce a change in the differentiation status or process in T cells?. Methods. We will consider two stochastic Markov chain models, one which will describe the T-helper cell differentiation process, and another one describing that process of infection of the T-helper cell by
arxiv