Results 251 to 260 of about 728,235 (280)

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Primary and secondary metabolites and their biological activity

, 2008
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Primary and Secondary Metabolites in Lotus japonicus

Journal of Agricultural and Food Chemistry, 2023
Lotus japonicus is a leguminous model plant used to gain insight into plant physiology, stress response, and especially symbiotic plant-microbe interactions, such as root nodule symbiosis or arbuscular mycorrhiza. Responses to changing environmental conditions, stress, microbes, or insect pests are generally accompanied by changes in primary and ...
Josef L. Ranner, Sabrina Schalk, Cindy Martyniak, Martin Parniske, Caroline Gutjahr, Timo D. Stark, Corinna Dawid   +6 more
openaire   +3 more sources

Primary, secondary, and tertiary metabolite kinetics

Journal of Pharmacokinetics and Biopharmaceutics, 1988
Because of the propensity of nascently formed metabolites towards sequential metabolism within formation organs, theoretical and experimental treatments that achieve mass conservation must recognize the various sources contributing to primary, secondary, and tertiary metabolite formation. A simple one-compartment open model, with first-order conditions
M V, St-Pierre, X, Xu, K S, Pang
openaire   +2 more sources

Metabolite diagnosis of primary hyperoxaluria type 3

Pediatric Nephrology, 2018
Primary hyperoxaluria type 3 (PH3) is a recently described cause of childhood renal calculi. It results from mutations in the HOGA1 gene and most cases have been diagnosed after clinical ascertainment, exclusion of other genetic hyperoxalurias and mutation testing. Metabolite testing has not been widely applied but holds promise for the rapid screening
Lawrence, Greed, Frank, Willis, Lilian, Johnstone, Sharon, Teo, Ruth, Belostotsky, Yaacov, Frishberg, James, Pitt   +6 more
openaire   +2 more sources

Synthesis of a Primary Metabolite of Cannabidiol

Organic Letters, 2000
Cannabidiol 1 is the major nonpsychotropic, neutral constituent in most cannabis preparations. It is devoid of the psychoactive properties typical of cannabis; however, it produces numerous, potentially therapeutic pharmacological effects, some of which may be due to its metabolites.
S, Tchilibon, R, Mechoulam
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EFFECT OF PRIMARY METABOLITES ON SECONDARY METABOLISM

Annual Review of Microbiology, 1977
CONTENTS INTRODUCTION . . . . . . . . . . 344 Regulation of Primary Metabolism 344 INDUCTION IN SECONDARY METABOLITE PATHWAYS 345 FEEDBACK REGULATION IN SECONDARY METABOLISM 348 Effect on Secondary Metabolism by Feedback Regulation of Primary Precursor Biosynthesis 348 Regulation of Secondary Metabolism by Primary End Products of a Common ...
S W, Drew, A L, Demain
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Primary metabolites of Phaseolus vulgaris nodules

Phytochemistry, 1978
Abstract More ethanol soluble material (carbohydrate and amino nitrogen) was found in both host cell and bacteroid components of Phaseolus vulgaris nodules from plants grown at 28 W/m2 than from plants grown at 7 W/m2. The range of compounds identified was similar at the two irradiances.
Linda D. Antoniw, Janet I. Sprent
openaire   +1 more source