Results 81 to 90 of about 1,293,597 (281)

Lenstra-Hurwitz Cliques In Real Quadratic Fields [PDF]

, 2018
Let $K$ be a number field and let $\OO_K$ denote its ring of integers. We can define a graph whose vertices are the elements of $\OO_K$ such that an edge exists between two algebraic integers if their difference is in the units $\OO_K^{\times}$.
Lopez, Daniel S
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Special prime numbers and discrete logs in finite prime fields [PDF]

Mathematics of Computation, 2000
Summary: A set \(A\) of primes \(p\) involving numbers such as \(ab^t+c\), where \(| a|,| b|,| c|=O(1)\) and \(t\to\infty\), is defined. An algorithm for computing discrete logs in the finite field of order \(p\) with \(p\in A\) is suggested. Its heuristic expected running time is \(L_p[\frac13;(\frac{32}{9})^{1/3}]\) for \((\frac{32}{9})^{1/3}=1.526 ...
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Malaphoric $$Z^\prime $$ Z ′ models for $$b \rightarrow s \ell ^+ \ell ^-$$ b → s ℓ + ℓ - anomalies

European Physical Journal C: Particles and Fields
We study some phenomenological effects of kinetic mixing between the hypercharge field and a new U(1) gauge field in specific $$Z^\prime $$ Z ′ models that ameliorate the tensions between measurements and Standard Model predictions in $$b \rightarrow s ...
Ben Allanach, Nico Gubernari
doaj   +1 more source

Prime rational functions over a field

, 2022
The aim of this paper is to provide sufficient conditions for when a polynomial or rational function over a field K is prime using its order of vanishing at infinity and the resultant.
Goedhart, Eva, Kihel, Omar, Larone, Jesse   +2 more
openaire   +2 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Constacyclic codes over finite local Frobenius non-chain rings of length 5 and nilpotency index 4

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020
The family of finite local Frobenius non-chain rings of length 5 and nilpotency index 4 is determined, as a by-product all finite local Frobenius non-chain rings with p5 elements (p a prime) and nilpotency index 4 are given.
Castillo-Guillén C. A., Rentería-Márquez C.   +1 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source