Results 81 to 90 of about 10,903,755 (367)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Infinite Towers of Galois Defect Extensions of Kaplansky Fields

Annales Mathematicae Silesianae, 2018
We give conditions for Kaplansky fields to admit infinite towers of Galois defect extensions of prime degree. As proofs of the presented facts are constructive, this provides examples of constructions of infinite towers of Galois defect extensions of ...
Blaszczok Anna
doaj   +1 more source

Lenstra-Hurwitz Cliques In Real Quadratic Fields [PDF]

, 2018
Let $K$ be a number field and let $\OO_K$ denote its ring of integers. We can define a graph whose vertices are the elements of $\OO_K$ such that an edge exists between two algebraic integers if their difference is in the units $\OO_K^{\times}$.
Lopez, Daniel S
core   +1 more source

Primes in quadratic fields

, 2010
This paper presents algorithms for calculating the quadratic character and the norms of prime ideals in the ring of integers of any quadratic field. The norms of prime ideals are obtained by means of a sieve algorithm using the quadratic character for the field considered.
openaire   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Sequences in finite fields yielding divisors of Mersenne, Fermat and Lehmer numbers, II [PDF]

Notes on Number Theory and Discrete Mathematics
Let ρ be an odd prime ≥ 11. In Part I, starting from an M-cycle in a finite field 𝔽_ρ, we have established how the divisors of Mersenne, Fermat and Lehmer numbers arise.
A. M. S. Ramasamy
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Intrinsic 1 $${T}^{{\prime} }$$ T ′ phase induced in atomically thin 2H-MoTe2 by a single terahertz pulse

Nature Communications, 2023
The polymorphic transition from 2H to 1 $${T}^{{\prime} }$$ T ′ -MoTe2, which was thought to be induced by high-energy photon irradiation among many other means, has been intensely studied for its technological relevance in nanoscale transistors due to ...
Jiaojian Shi, Ya-Qing Bie, Alfred Zong, Shiang Fang, Wei Chen, Jinchi Han, Zhaolong Cao, Yong Zhang, Takashi Taniguchi, Kenji Watanabe, Xuewen Fu, Vladimir Bulović, Efthimios Kaxiras, Edoardo Baldini, Pablo Jarillo-Herrero, Keith A. Nelson   +15 more
doaj   +1 more source