Results 61 to 70 of about 143,448 (228)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Eigenvalues of Sturm-Liouville operators and prime numbers
Electronic Journal of Differential Equations, 2017 We show that there is no function $q(x)\in L_2(0,1)$ which is the potential of a Sturm-Liouville problem with Dirichlet boundary condition whose spectrum is a set depending nonlinearly on the set of prime numbers as suggested by Mingarelli [7].
Rauf Amirov, Ibrahim Adalar
doaj
Along the Lines of Nonadditive Entropies: q-Prime Numbers and q-Zeta Functions. [PDF]
Entropy (Basel), 2021 Borges EP, Kodama T, Tsallis C.
europepmc +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Pseudo-prime number simulation and its application for security purpose
MATEC Web of Conferences, 2018 Many public cryptography schemes rely on the use of prime numbers like for encryption and decryption. A prime number is one number that is widely used and large and consists of hundreds of digits, so it takes time to test whether the numbers are prime or
Rahim Robbi +10 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Arab Journal of Basic and Applied SciencesThis paper introduces a new key geometric way to understand Mersenne prime numbers. It discovers a shape called the Mersenne Star, which appears naturally from a special sequence named the Quanta Prime Sequence (QPS).
Moustafa Ibrahim
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Computational challenges and solutions: Prime number generation for enhanced data security.
PLoS ONEThis paper addresses the computational methods and challenges associated with prime number generation, a critical component in encryption algorithms for ensuring data security.
Amal Ezz-Eldien +6 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source