Results 111 to 120 of about 97,942 (322)

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Chronic Wasting Disease Research in North America: A systematic review highlighting species-wise and interdisciplinary research trends

Prion
Chronic Wasting Disease (CWD) research has experienced significant growth, spanning diverse disciplines such as genetics, immunology, modelling, and behaviour.
Chandika RG, Anaïs Tallon, Emily K. Latch   +2 more
doaj   +1 more source

The role of the prion protein in the immune system [PDF]

, 2013
Veronika Kana
openalex   +1 more source

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

PLoS Pathogens, 2016
The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate.
E. Vázquez-Fernández, M. Vos, P. Afanasyev, L. Cebey, Alejandro M. Sevillano, E. Vidal, I. Rosa, L. Renault, Adriana Ramos, P. Peters, J. Fernández, M. van Heel, H. Young, J. Requena, H. Wille   +14 more
semanticscholar   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Differential pathology of P102L-associated Gerstmann–Stäussler–Scheinker disease: exclusive presence of 8-kDa protease-resistant prion protein vs. co-existence of 8-kDa and type-1 protease-resistant prion protein, with a focus on codon 129 polymorphism

Prion
Gerstmann – Sträussler – Scheinker disease (GSS) is a hereditary prion disease characterized by clinicopathological heterogeneity. In Japan, the most common mutation is P102L, typically associated with prion protein (PrP) plaques, spongiform changes, and
Hideko Noguchi, Motoi Yoshimura, Akihiro Watanabe, Sachiko Koyama, Naonori Sakurada, Masahiro Shijo, Takaaki Kanemaru, Keita Kai, Shinichi Aishima, Haruki Koike, Yoshio Tsuboi, Naokazu Sasagasako, Hiroyuki Honda   +12 more
doaj   +1 more source

Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress [PDF]

, 2014
Takashi Onodera, Akikazu Sakudo, Hirokazu Tsubone, Shigeyoshi Itohara   +3 more
openalex   +1 more source

Prion-like spreading of pathological α-synuclein in brain

Brain : a journal of neurology, 2013
α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular mechanisms underlying α-synuclein accumulation and spread are unclear.
Masami Masuda-Suzukake, T. Nonaka, M. Hosokawa, Takayuki Oikawa, T. Arai, H. Akiyama, D. Mann, M. Hasegawa   +7 more
semanticscholar   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease

Prion
An early diagnosis is required for intervention in prion disease cases. To elucidate the specificity of early electroencephalography discharges in cases of sporadic Creutzfeldt-Jakob disease, we analysed epileptiform discharges through ...
Taiki Matsubayashi, Hirokazu Natsui, Katsuya Satoh, Tetsuyuki Kitamoto, Takanori Yokota, Nobuo Sanjo   +5 more
doaj   +1 more source