Results 211 to 220 of about 69,500 (311)
Prion shedding is reduced by chronic wasting disease vaccination. [PDF]
Ahmed-Hassan H +10 more
europepmc +1 more source
Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo +10 more
wiley +1 more source
A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation. [PDF]
Fang A +20 more
europepmc +1 more source
Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan +18 more
wiley +1 more source
Preclinical serum alterations and tissue changes in protein and gene expression of early cerebrospinal fluid-validated biomarkers in scrapie. [PDF]
Pérez-Lázaro S +4 more
europepmc +1 more source
Involvement of the spleen in the anti-prion activity of hydroxypropyl methylcellulose in mice. [PDF]
Teruya K +3 more
europepmc +1 more source
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala +4 more
wiley +1 more source
Prion Protein Codon Implicated in Resistance in Dogs Detected in Non-Domesticated Members of Mammalia. [PDF]
Wright EA +6 more
europepmc +1 more source
Abstract As our understanding of genetic risk and the availability of genetic testing increases, consideration of the psychological impact of living at risk for an autosomal dominant neurological condition (ADNC) becomes more pertinent. A systematic search of PsycINFO, MEDLINE, and Web of Science was run to identify studies exploring the psychological ...
Rhianna Brien +3 more
wiley +1 more source

