Results 221 to 230 of about 69,500 (311)

Author Correction: A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva

Scientific Reports
Kaitlyn Wagner, Phil Fox, Elizabeth Gordon, Westen Hahn, Kenzie Olsen, Alex Markham, Dylan Buglewicz, Platon Selemenakis, Avery Lessard, Daniella Goldstein, Alissa Threatt, Luke Davis, Jake Miller-Dawson, Halie Stockett, Hailey Sanders, Kristin Rugh, Houston Turner, Michelle Remias, Maggie Williams, Jorge Chavez, Gabriel Galindo, Charlotte Cialek, Amanda Koch, Alex Fout, Bailey Fosdick, Bettina Broeckling, Mark D. Zabel   +26 more
doaj   +1 more source

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Bovine Spongiform Encephalopathy: An Integrated Review of Prion Mechanisms, Neuroanatomy, and Control. [PDF]

Vet Sci
Marzola GP, Abuna RPF, Ribeiro LA, Parra JPRLL, Garcia MHH, Maria Barbalho S, Miglino MA.   +6 more
europepmc   +1 more source

Progress of Immunotherapies in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng, Xu‐hui Kang, Shun‐yu Yao, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Dai‐yi Jiang, Quan Chen, Hong Jin   +10 more
wiley   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP‐Induced Mouse Model of Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Oxidative stress induced by MPTP promotes hnRNP A1/A2–dependent alternative splicing toward PKM2 in dopaminergic neurons. Elevated PKM2 transactivates Nrf2, enhances antioxidant gene expression, and protects neurons from oxidative damage and degeneration.
Meng Mei, Qian‐qian Miao, Meng‐ke Li, Hao‐ran Wang, Jian‐hua Ding, Gang Hu, Yao Wei   +6 more
wiley   +1 more source

Theory and simulations of delayed stochastic and deterministic models of prion diseases. [PDF]

J Math Biol
Boregowda G, Sharif O, Gutierrez Iii D, Simmons A, Pujo-Menjouet L, Oraby T, Lindstrom MR.   +6 more
europepmc   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Copper Coordination to the Prion Fragment (95-126): Implications for Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Bacchella C, Ferraresi A, Monzani E, Dell'Acqua S.   +3 more
europepmc   +1 more source

Networks of Indirect Contact Promote Spread of an Environmentally Transmitted Pathogen in a Highly Social Species

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using behavioral observations and network simulations, we evaluate direct and indirect transmission of the MTBC pathogen M. mungi in banded mongooses. Incorporating intergroup scent marking reveals that environmentally mediated, socially directed pathways can promote spread at low transmissibility, elevating population prevalence even when direct ...
Jack R. Leitch, Neil R. Jordan, John M. Drake, Michael A. Cant, Kathleen A. Alexander   +4 more
wiley   +1 more source

mGem: Cut4/Apc1 and its prion form at the cross roads of cell cycle regulation, heterochromatin organization, RNAi, stress response, and evolution. [PDF]

mBio
Sharma S, Singh J.
europepmc   +1 more source